BreastResectionDocument
type: Bundle
node role: treeRoot
id:
  v: BreastResectionDocument
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_002
type:
  v: document
timestamp:
  v: 2025-02-10T17:00:00+01:00
entry:
  full url:
    v: http://breastcancerspec.org/Composition/BreastResectionComposition
    l: BreastResectionComposition
  resource: BreastResectionComposition
entry:
  full url:
    v: http://breastcancerspec.org/Patient/Patient4
    l: Patient4
  resource: Patient4
entry:
  full url:
    v: http://breastcancerspec.org/Organization/PathologyLabOrganization
    l: PathologyLabOrganization
  resource: PathologyLabOrganization
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/PathologistPractitioner
    l: PathologistPractitioner
  resource: PathologistPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/BreastSurgeonPractitioner
    l: BreastSurgeonPractitioner
  resource: BreastSurgeonPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Encounter/BreastResectionEncounter
    l: BreastResectionEncounter
  resource: BreastResectionEncounter
entry:
  full url:
    v: http://breastcancerspec.org/Condition/BreastResectionDiagnosisConfirmed
    l: BreastResectionDiagnosisConfirmed
  resource: BreastResectionDiagnosisConfirmed
entry:
  full url:
    v: http://breastcancerspec.org/ServiceRequest/BreastResectionReportRequest
    l: BreastResectionReportRequest
  resource: BreastResectionReportRequest
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/BreastResectionImagingReport
    l: BreastResectionImagingReport
  resource: BreastResectionImagingReport
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionCancerHistory
    l: BreastResectionCancerHistory
  resource: BreastResectionCancerHistory
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionPriorTherapy
    l: BreastResectionPriorTherapy
  resource: BreastResectionPriorTherapy
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionRadiologicalExtent
    l: BreastResectionRadiologicalExtent
  resource: BreastResectionRadiologicalExtent
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionSpecimenMarking
    l: BreastResectionSpecimenMarking
  resource: BreastResectionSpecimenMarking
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionSpecimenRadiographyClinical
    l: BreastResectionSpecimenRadiographyClinical
  resource: BreastResectionSpecimenRadiographyClinical
entry:
  full url:
    v: http://breastcancerspec.org/Observation/BreastResectionGeneticPredisposition
    l: BreastResectionGeneticPredisposition
  resource: BreastResectionGeneticPredisposition
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/BreastResectionReport
    l: BreastResectionReport
  resource: BreastResectionReport
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenPart
    l: BreastResectionSpecimenPart
  resource: BreastResectionSpecimenPart
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock01
    l: BreastResectionSpecimenBlock01
  resource: BreastResectionSpecimenBlock01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock02
    l: BreastResectionSpecimenBlock02
  resource: BreastResectionSpecimenBlock02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock03
    l: BreastResectionSpecimenBlock03
  resource: BreastResectionSpecimenBlock03
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock04
    l: BreastResectionSpecimenBlock04
  resource: BreastResectionSpecimenBlock04
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock05
    l: BreastResectionSpecimenBlock05
  resource: BreastResectionSpecimenBlock05
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock06
    l: BreastResectionSpecimenBlock06
  resource: BreastResectionSpecimenBlock06
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock07
    l: BreastResectionSpecimenBlock07
  resource: BreastResectionSpecimenBlock07
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHE01
    l: BreastResectionSpecimenSlideHE01
  resource: BreastResectionSpecimenSlideHE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHE02
    l: BreastResectionSpecimenSlideHE02
  resource: BreastResectionSpecimenSlideHE02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideER01
    l: BreastResectionSpecimenSlideER01
  resource: BreastResectionSpecimenSlideER01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlidePR01
    l: BreastResectionSpecimenSlidePR01
  resource: BreastResectionSpecimenSlidePR01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHER2IHC01
    l: BreastResectionSpecimenSlideHER2IHC01
  resource: BreastResectionSpecimenSlideHER2IHC01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideKi67-01
    l: BreastResectionSpecimenSlideKi67-01
  resource: BreastResectionSpecimenSlideKi67-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideCK18-01
    l: BreastResectionSpecimenSlideCK18-01
  resource: BreastResectionSpecimenSlideCK18-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlidep40-01
    l: BreastResectionSpecimenSlidep40-01
  resource: BreastResectionSpecimenSlidep40-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideECad-01
    l: BreastResectionSpecimenSlideECad-01
  resource: BreastResectionSpecimenSlideECad-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideBlock02-HE01
    l: BreastResectionSpecimenSlideBlock02-HE01
  resource: BreastResectionSpecimenSlideBlock02-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideBlock02-HE02
    l: BreastResectionSpecimenSlideBlock02-HE02
  resource: BreastResectionSpecimenSlideBlock02-HE02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Superior-HE01
    l: BreastResectionSpecimenSlideRR-Superior-HE01
  resource: BreastResectionSpecimenSlideRR-Superior-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Inferior-HE01
    l: BreastResectionSpecimenSlideRR-Inferior-HE01
  resource: BreastResectionSpecimenSlideRR-Inferior-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Medial-HE01
    l: BreastResectionSpecimenSlideRR-Medial-HE01
  resource: BreastResectionSpecimenSlideRR-Medial-HE01

BreastResectionComposition
type: Composition
id:
  v: BreastResectionComposition
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Composition BreastResectionComposition identifier: Accession ID/PATH-COMP-2025-210 status: Final type: Pathology report (record artifact) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_210; status = finished; class = IMP (IMP) date: 2025-02-10 17:00:00+0100 author: Institut für Pathologie title: Pathologisch-Anatomische Begutachtung - Makroskopische Beurteilung (BET) Attesters - Mode Party * Legal Organization Institut für Pathologie custodian: Organization Institut für Pathologie Events - Code Detail * pathology report entry task ServiceRequest Pathology synoptic report
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: http://example.hospital.de/pathology-reports
    l: pathology-reports
  value:
    v: PATH-COMP-2025-210
status:
  v: final
type:
  coding:
    system:
      v: http://ihe-d.de/CodeSystems/IHEXDStypeCode
      l: IHEXDStypeCode
    code:
      v: PATH
  coding: http://snomed.info/id/371528001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371528001
    display:
      v: Pathology report (record artifact)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
  display:
    v: Sabine Becker, geb. 15.03.1971 (PAT-2025-105)
encounter:
  l: BreastResectionEncounter
  reference:
    v: Encounter/BreastResectionEncounter
date:
  v: 2025-02-10T17:00:00+01:00
author:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
  display:
    v: Institut für Pathologie
title:
  v: Pathologisch-Anatomische Begutachtung - Makroskopische Beurteilung (BET)
attester:
  mode:
    v: legal
  party:
    l: PathologyLabOrganization
    reference:
      v: Organization/PathologyLabOrganization
custodian:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
event:
  code:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v3-ActCode
        l: v3-ActCode
      code:
        v: PATREPE
  detail:
    l: BreastResectionReportRequest
    reference:
      v: ServiceRequest/BreastResectionReportRequest
section:
  title:
    v: Pathologiebefundbericht
  code:
    coding: https://loinc.org/rdf/11526-1
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 11526-1
      display:
        v: Pathology study
  text:
    status:
      v: additional
    div:
      v: Klinische Angaben Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links indiziert. Drahthäkchenmarkierung. Keine neoadjuvante Therapie. Ersterkrankung. Keine bekannte genetische Prädisposition. Präparateradiographie beigelegt. Material BET-Exzisionspräparat Mamma links, mit Haut, Drahthäkchen in situ Makroskopie Größe 42 × 35 × 18 mm Gewicht 10 g Quadrant Unterer äußerer Quadrant Zifferblatt 5 Uhr Abstand Mamille 50 mm Lamellierung 8 Scheiben à 5 mm Schnittfläche Grau-weißlich, derber Herdbefund zentral in Scheibe III–V, ca. 18 mm Paraffinblöcke 7 Mikroskopie Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Zentrale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion. Diagnose Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c ICD-10 C50.5 ICD-O-3 Morphologie M8500/3 Operatives Verfahren BET (brusterhaltende Therapie) Seitenlokalisation Links Fokalität Unifokal Max. Durchmesser invasiv 18 mm Max. Gesamtdurchmesser 22 mm Nottingham-Grad Grad 2 (Score 6: Tubuli 3, Pleomorphie 2, Mitosen 1) Assoziiertes DCIS Vorhanden, ohne extensive intraduktale Komponente (EIC), intermediärer Kerngrad, kribriform, zentrale Komedo-Nekrosen Tumorausdehnung Auf Brustdrüse beschränkt pT-Kategorie pT1c Resektionsränder RR-Status invasiv Nicht befallen (R0) Nächster tumorfreier RR Posterior Mindestabstand invasiv 5 mm RR-Status DCIS Nicht befallen Mindestabstand DCIS 3 mm Biomarker ER Positiv (90%, stark) PR Positiv (60%, mäßig) HER2 (IHC) 1+ HER2 (ISH) Nicht amplif…
  entry:
    l: BreastResectionReport
    reference:
      v: DiagnosticReport/BreastResectionReport

Patient4
type: Patient
id:
  v: Patient4
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Patient Patient4 Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/patient-ids
    l: patient-ids
  value:
    v: PAT-2025-105
name:
  family:
    v: Becker
  given:
    v: Sabine
gender:
  v: female
birth date:
  v: 1971-03-15

PathologyLabOrganization
type: Organization
id:
  v: PathologyLabOrganization
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Organization PathologyLabOrganization identifier: http://example.hospital.de/organization-ids/ORG-PATH-001 name: Institut für Pathologie
identifier:
  system:
    v: http://example.hospital.de/organization-ids
    l: organization-ids
  value:
    v: ORG-PATH-001
name:
  v: Institut für Pathologie

PathologistPractitioner
type: Practitioner
id:
  v: PathologistPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner PathologistPractitioner identifier: http://example.hospital.de/practitioner-ids/PATH-001 name: Elisabeth Hoffmann Qualifications - Code * Pathology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: PATH-001
name:
  family:
    v: Hoffmann
  given:
    v: Elisabeth
  prefix:
    v: Dr.
qualification:
  code:
    coding: http://snomed.info/id/394595002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394595002
      display:
        v: Pathology

BreastSurgeonPractitioner
type: Practitioner
id:
  v: BreastSurgeonPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner BreastSurgeonPractitioner identifier: http://example.hospital.de/practitioner-ids/GYN-001 name: Thomas Richter Qualifications - Code * Gynecology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: GYN-001
name:
  family:
    v: Richter
  given:
    v: Thomas
  prefix:
    v: Prof. Dr.
qualification:
  code:
    coding: http://snomed.info/id/394586005
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394586005
      display:
        v: Gynecology

BreastResectionEncounter
type: Encounter
id:
  v: BreastResectionEncounter
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Encounter BreastResectionEncounter identifier: http://example.hospital.de/encounters/E_25_210 status: Finished class: [not stated]: IMP (IMP) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/encounters
    l: encounters
  value:
    v: E_25_210
status:
  v: finished
class:
  code:
    v: IMP
subject:
  l: Patient4
  reference:
    v: Patient/Patient4

BreastResectionDiagnosisConfirmed
type: Condition
id:
  v: BreastResectionDiagnosisConfirmed
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Condition BreastResectionDiagnosisConfirmed Profile: MII PR Diagnose Condition version: 2026.0.0 clinicalStatus: Active verificationStatus: Confirmed category: Encounter Diagnosis code: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_210; status = finished; class = IMP (IMP) onset: 2025-01-15 recordedDate: 2025-02-05 note: Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links indiziert.
clinical status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-clinical
      l: condition-clinical
    code:
      v: active
verification status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-ver-status
      l: condition-ver-status
    code:
      v: confirmed
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-category
      l: condition-category
    code:
      v: encounter-diagnosis
code:
  coding:
    system:
      v: http://fhir.de/CodeSystem/bfarm/icd-10-gm
      l: icd-10-gm
    version:
      v: 2025
    code:
      v: C50.5
    display:
      v: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: BreastResectionEncounter
  reference:
    v: Encounter/BreastResectionEncounter
onset: DateTime
  v: 2025-01-15
recorded date:
  v: 2025-02-05
note:
  text:
    v: Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links indiziert.

BreastResectionReportRequest
type: ServiceRequest
id:
  v: BreastResectionReportRequest
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request
text:
  status:
    v: generated
  div:
    v: Generated Narrative: ServiceRequest BreastResectionReportRequest Profile: MII PR Patho Service Request version: 2026.0.0 identifier: Placer Identifier/PATH-RPT-2025-210 status: Completed intent: Order category: Pathology consultation, comprehensive, records and specimen with report (procedure) code: Pathology synoptic report subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_210; status = finished; class = IMP (IMP) requester: Practitioner Thomas Richter performer: Practitioner Elisabeth Hoffmann reasonCode: Malignant neoplasm of breast (disorder) supportingInfo: Condition Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse Diagnostic Report for 'MG Breast Screening' for '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Observation Personal history of primary malignant neoplasm of breast (situation) Observation Cancer treatment --preoperative Observation Lesion size, largest dimension (observable entity) Observation Insertion of marker into breast using X-ray guidance (procedure) Observation 80865008|Specimen mammography|:363702006|Has focus|=185008008|Medical reports sent| Observation Diathesis, function (observable entity) Observation Quadrant Breast Observation Radial position in breast [Angle] in Breast cancer specimen Observation Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity) Observation Screening interpretation (observable entity) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
      display:
        v: Placer Identifier
  system:
    v: http://example.hospital.de/serviceRequest
    l: serviceRequest
  value:
    v: PATH-RPT-2025-210
status:
  v: completed
intent:
  v: order
category:
  coding: http://snomed.info/id/726007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 726007
    display:
      v: Pathology consultation, comprehensive, records and specimen with report (procedure)
code:
  coding: https://loinc.org/rdf/60568-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 60568-3
    display:
      v: Pathology synoptic report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: BreastResectionEncounter
  reference:
    v: Encounter/BreastResectionEncounter
requester:
  l: BreastSurgeonPractitioner
  reference:
    v: Practitioner/BreastSurgeonPractitioner
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
reason code:
  coding: http://snomed.info/id/254837009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 254837009
    display:
      v: Malignant neoplasm of breast (disorder)
supporting info:
  l: BreastResectionDiagnosisConfirmed
  reference:
    v: Condition/BreastResectionDiagnosisConfirmed
supporting info:
  l: BreastResectionImagingReport
  reference:
    v: DiagnosticReport/BreastResectionImagingReport
supporting info:
  l: BreastResectionCancerHistory
  reference:
    v: Observation/BreastResectionCancerHistory
supporting info:
  l: BreastResectionPriorTherapy
  reference:
    v: Observation/BreastResectionPriorTherapy
supporting info:
  l: BreastResectionRadiologicalExtent
  reference:
    v: Observation/BreastResectionRadiologicalExtent
supporting info:
  l: BreastResectionSpecimenMarking
  reference:
    v: Observation/BreastResectionSpecimenMarking
supporting info:
  l: BreastResectionSpecimenRadiographyClinical
  reference:
    v: Observation/BreastResectionSpecimenRadiographyClinical
supporting info:
  l: BreastResectionGeneticPredisposition
  reference:
    v: Observation/BreastResectionGeneticPredisposition
supporting info:
  l: BreastResectionMacroQuadrant
  reference:
    v: Observation/BreastResectionMacroQuadrant
supporting info:
  l: BreastResectionMacroClock
  reference:
    v: Observation/BreastResectionMacroClock
supporting info:
  l: BreastResectionMacroDistanceNipple
  reference:
    v: Observation/BreastResectionMacroDistanceNipple
supporting info:
  l: CoreNeedleBiopsyInterpretation
  reference:
    v: Observation/CoreNeedleBiopsyInterpretation
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart

BreastResectionImagingReport
type: DiagnosticReport
id:
  v: BreastResectionImagingReport
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport BreastResectionImagingReport MG Breast Screening (Radiology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-01-08 Report Details BI-RADS 4b: Herdbefund linke Brust, unterer äußerer Quadrant, 5 Uhr, 5 cm von Mamille. Radiologische Ausdehnung ca. 15 mm. Mammografie und Ultraschall. Indikation zur BET.
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: RAD
    display:
      v: Radiology
code:
  coding: https://loinc.org/rdf/24606-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 24606-6
    display:
      v: MG Breast Screening
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-08
conclusion:
  v: BI-RADS 4b: Herdbefund linke Brust, unterer äußerer Quadrant, 5 Uhr, 5 cm von Mamille. Radiologische Ausdehnung ca. 15 mm. Mammografie und Ultraschall. Indikation zur BET.

BreastResectionCancerHistory
type: Observation
id:
  v: BreastResectionCancerHistory
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionCancerHistory status: Final code: Brustkrebsvorgeschichte subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Ersterkrankung
status:
  v: final
code:
  coding: http://snomed.info/id/415076002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 415076002
    display:
      v: Personal history of primary malignant neoplasm of breast (situation)
  text:
    v: Brustkrebsvorgeschichte
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  text:
    v: Ersterkrankung

BreastResectionPriorTherapy
type: Observation
id:
  v: BreastResectionPriorTherapy
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionPriorTherapy status: Final code: Vorchirurgische Therapie bei invasivem Karzinom subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Keine neoadjuvante Therapie
status:
  v: final
code:
  coding: https://loinc.org/rdf/81167-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 81167-9
    display:
      v: Cancer treatment --preoperative
  text:
    v: Vorchirurgische Therapie bei invasivem Karzinom
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/373067005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 373067005
    display:
      v: No (qualifier value)
  text:
    v: Keine neoadjuvante Therapie

BreastResectionRadiologicalExtent
type: Observation
id:
  v: BreastResectionRadiologicalExtent
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionRadiologicalExtent status: Final code: Radiologische Ausdehnung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: 15 mm (Details: UCUM codemm = 'mm')
status:
  v: final
code:
  coding: http://snomed.info/id/396361002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 396361002
    display:
      v: Lesion size, largest dimension (observable entity)
  text:
    v: Radiologische Ausdehnung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: Quantity
  value:
    v: 15
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm

BreastResectionSpecimenMarking
type: Observation
id:
  v: BreastResectionSpecimenMarking
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionSpecimenMarking status: Final code: Befundmarkierung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Drahthäkchen
status:
  v: final
code:
  coding: http://snomed.info/id/836381000000102
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 836381000000102
    display:
      v: Insertion of marker into breast using X-ray guidance (procedure)
  text:
    v: Befundmarkierung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  text:
    v: Drahthäkchen

BreastResectionSpecimenRadiographyClinical
type: Observation
id:
  v: BreastResectionSpecimenRadiographyClinical
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionSpecimenRadiographyClinical status: Final code: Präparateradiographie beigelegt subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Ja, beigelegt
status:
  v: final
code:
  coding:
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 80865008:363702006=185008008
    display:
      v: 80865008|Specimen mammography|:363702006|Has focus|=185008008|Medical reports sent|
  text:
    v: Präparateradiographie beigelegt
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: Ja, beigelegt

BreastResectionGeneticPredisposition
type: Observation
id:
  v: BreastResectionGeneticPredisposition
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionGeneticPredisposition status: Final code: Genetische Prädisposition subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Nicht bekannt
status:
  v: final
code:
  coding: http://snomed.info/id/76522002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76522002
    display:
      v: Diathesis, function (observable entity)
  text:
    v: Genetische Prädisposition
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/261665006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 261665006
    display:
      v: Unknown (qualifier value)
  text:
    v: Nicht bekannt

BreastResectionReport
type: DiagnosticReport
id:
  v: BreastResectionReport
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport BreastResectionReport Profile: MII PR Patho Report version: 2026.0.0 Pathology Synoptic report (Surgical Pathology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-02-10 14:00:00+0100 Reported 2025-02-10 17:00:00+0100 Performer Practitioner Elisabeth Hoffmann Identifier Accession ID/E_25_210 Report Details Code Value Flags When For Pathology report gross observation Narrative (Breast structure (body structure)) Final 2025-02-06 08:30:00+0100 Pathology report final diagnosis Narrative Final 2025-02-10 Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c, Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: SP
    display:
      v: Surgical Pathology
code:
  coding: https://loinc.org/rdf/60568-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 60568-3
    display:
      v: Pathology Synoptic report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10T14:00:00+01:00
issued:
  v: 2025-02-10T17:00:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
specimen:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
specimen:
  l: BreastResectionSpecimenBlock02
  reference:
    v: Specimen/BreastResectionSpecimenBlock02
specimen:
  l: BreastResectionSpecimenBlock03
  reference:
    v: Specimen/BreastResectionSpecimenBlock03
specimen:
  l: BreastResectionSpecimenBlock04
  reference:
    v: Specimen/BreastResectionSpecimenBlock04
specimen:
  l: BreastResectionSpecimenBlock05
  reference:
    v: Specimen/BreastResectionSpecimenBlock05
specimen:
  l: BreastResectionSpecimenBlock06
  reference:
    v: Specimen/BreastResectionSpecimenBlock06
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
specimen:
  l: BreastResectionSpecimenSlideHE02
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE02
specimen:
  l: BreastResectionSpecimenSlideER01
  reference:
    v: Specimen/BreastResectionSpecimenSlideER01
specimen:
  l: BreastResectionSpecimenSlidePR01
  reference:
    v: Specimen/BreastResectionSpecimenSlidePR01
specimen:
  l: BreastResectionSpecimenSlideHER2IHC01
specimen:
  l: BreastResectionSpecimenSlideKi67-01
  reference:
    v: Specimen/BreastResectionSpecimenSlideKi67-01
specimen:
  l: BreastResectionSpecimenSlideCK18-01
  reference:
    v: Specimen/BreastResectionSpecimenSlideCK18-01
specimen:
  l: BreastResectionSpecimenSlidep40-01
  reference:
    v: Specimen/BreastResectionSpecimenSlidep40-01
specimen:
  l: BreastResectionSpecimenSlideECad-01
  reference:
    v: Specimen/BreastResectionSpecimenSlideECad-01
specimen:
  l: BreastResectionSpecimenSlideBlock02-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideBlock02-HE01
specimen:
  l: BreastResectionSpecimenSlideBlock02-HE02
  reference:
    v: Specimen/BreastResectionSpecimenSlideBlock02-HE02
specimen:
  l: BreastResectionSpecimenSlideRR-Superior-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Superior-HE01
specimen:
  l: BreastResectionSpecimenSlideRR-Inferior-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Inferior-HE01
specimen:
  l: BreastResectionSpecimenSlideRR-Medial-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Medial-HE01
specimen:
  l: BreastResectionSpecimenSlideRR-Lateral-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Lateral-HE01
result:
  l: BreastResectionMacroscopicGrouper
  reference:
    v: Observation/BreastResectionMacroscopicGrouper
result:
  l: BreastResectionDiagnosticConclusionGrouper
  reference:
    v: Observation/BreastResectionDiagnosticConclusionGrouper
conclusion:
  v: Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c, Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%.

BreastResectionSpecimenPart
type: Specimen
id:
  v: BreastResectionSpecimenPart
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenPart Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: Placer Identifier/OP25_210_A, Filler Identifier/E_25_210_A accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Specimen from breast obtained by excision (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) request: ServiceRequest Pathology synoptic report Collections - Collector Collected[x] Method BodySite * Practitioner Thomas Richter 2025-02-05 10:00:00+0100 Wide local excision of breast lesion (procedure) Structure of lower outer quadrant of breast (body structure) Containers - Type Additive[x] * Specimen vial (physical object) Neutral buffered formalin (substance) note: BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
  system:
    v: https://senologie.example-hospital.de/fhir/specimen/placer
    l: placer
  value:
    v: OP25_210_A
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: FILL
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/397199005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 397199005
    display:
      v: Specimen from breast obtained by excision (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
request:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
collection:
  collector:
    l: BreastSurgeonPractitioner
    reference:
      v: Practitioner/BreastSurgeonPractitioner
  collected: DateTime
    v: 2025-02-05T10:00:00+01:00
  method:
    coding: http://snomed.info/id/237371007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 237371007
      display:
        v: Wide local excision of breast lesion (procedure)
  body site:
    coding: http://snomed.info/id/33564002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 33564002
      display:
        v: Structure of lower outer quadrant of breast (body structure)
container:
  type:
    coding: http://snomed.info/id/434746001
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434746001
      display:
        v: Specimen vial (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/434162003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434162003
      display:
        v: Neutral buffered formalin (substance)
note:
  text:
    v: BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.

BreastResectionSpecimenBlock01
type: Specimen
id:
  v: BreastResectionSpecimenBlock01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:00:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe III Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:00:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:00:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe III
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:00:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock02
type: Specimen
id:
  v: BreastResectionSpecimenBlock02
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_2 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:10:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe V Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:10:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_2
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:10:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe V
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:10:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock03
type: Specimen
id:
  v: BreastResectionSpecimenBlock03
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock03 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_3 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:20:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Resektionsrand superior Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:20:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_3
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:20:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Resektionsrand superior
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:20:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock04
type: Specimen
id:
  v: BreastResectionSpecimenBlock04
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock04 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_4 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:25:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Resektionsrand inferior Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:25:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_4
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:25:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Resektionsrand inferior
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:25:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock05
type: Specimen
id:
  v: BreastResectionSpecimenBlock05
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock05 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_5 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:30:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Resektionsrand medial (Scheibe I) Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:30:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_5
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:30:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Resektionsrand medial (Scheibe I)
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:30:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock06
type: Specimen
id:
  v: BreastResectionSpecimenBlock06
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock06 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_6 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:35:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Resektionsrand lateral (Scheibe VIII) Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:35:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_6
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:35:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Resektionsrand lateral (Scheibe VIII)
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:35:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenBlock07
type: Specimen
id:
  v: BreastResectionSpecimenBlock07
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenBlock07 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_7 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. Collections - Collected[x] Method * 2025-02-06 08:40:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Resektionsrand posterior Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:40:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_7
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:40:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Resektionsrand posterior
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:40:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

BreastResectionSpecimenSlideHE01
type: Specimen
id:
  v: BreastResectionSpecimenSlideHE01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideHE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 1) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_HE_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 1)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideHE02
type: Specimen
id:
  v: BreastResectionSpecimenSlideHE02
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideHE02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HE_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 2) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_HE_02
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 2)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideER01
type: Specimen
id:
  v: BreastResectionSpecimenSlideER01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideER01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_ER_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: ER-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_ER_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:30:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: ER-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstanceER
    reference:
      v: Substance/BreastResectionSubstanceER
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlidePR01
type: Specimen
id:
  v: BreastResectionSpecimenSlidePR01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlidePR01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_PR_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:35:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:35:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: PR-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:05:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_PR_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:35:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:35:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: PR-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstancePR
    reference:
      v: Substance/BreastResectionSubstancePR
  time: DateTime
    v: 2025-02-06T10:05:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideHER2IHC01
type: Specimen
id:
  v: BreastResectionSpecimenSlideHER2IHC01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideHER2IHC01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HER2IHC_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:40:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:40:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HER2-Immunhistochemie procedure: Human epidermal growth factor receptor 2 gene detection by immunohistochemistry (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:30:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_HER2IHC_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:40:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:40:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HER2-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/433114000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433114000
      display:
        v: Human epidermal growth factor receptor 2 gene detection by immunohistochemistry (procedure)
  additive:
    l: BreastResectionSubstanceHER2IHC
  time: DateTime
    v: 2025-02-06T10:30:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideKi67-01
type: Specimen
id:
  v: BreastResectionSpecimenSlideKi67-01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideKi67-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_Ki67_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:45:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:45:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Ki-67 Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:10:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_Ki67_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:45:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:45:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Ki-67 Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstanceKi67
    reference:
      v: Substance/BreastResectionSubstanceKi67
  time: DateTime
    v: 2025-02-06T10:10:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideCK18-01
type: Specimen
id:
  v: BreastResectionSpecimenSlideCK18-01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideCK18-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_CK18_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:50:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:50:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: CK18-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:35:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_CK18_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:50:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:50:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: CK18-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstanceCK18
    reference:
      v: Substance/BreastResectionSubstanceCK18
  time: DateTime
    v: 2025-02-06T10:35:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlidep40-01
type: Specimen
id:
  v: BreastResectionSpecimenSlidep40-01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlidep40-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_p40_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:55:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:55:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: p40-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:40:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_p40_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:55:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:55:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: p40-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstancep40
    reference:
      v: Substance/BreastResectionSubstancep40
  time: DateTime
    v: 2025-02-06T10:40:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideECad-01
type: Specimen
id:
  v: BreastResectionSpecimenSlideECad-01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideECad-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_ECad_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 10:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 10:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: E-Cadherin-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:45:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_1_1_ECad_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock01
  reference:
    v: Specimen/BreastResectionSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T10:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: E-Cadherin-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: BreastResectionSubstanceECadherin
    reference:
      v: Substance/BreastResectionSubstanceECadherin
  time: DateTime
    v: 2025-02-06T10:45:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideBlock02-HE01
type: Specimen
id:
  v: BreastResectionSpecimenSlideBlock02-HE01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideBlock02-HE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_2_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:20:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 1) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:20:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:35:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_2_1_HE_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock02
  reference:
    v: Specimen/BreastResectionSpecimenBlock02
collection:
  collected: DateTime
    v: 2025-02-06T09:20:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 1)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:20:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:35:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSpecimenSlideBlock02-HE02
type: Specimen
id:
  v: BreastResectionSpecimenSlideBlock02-HE02
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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  reference:
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parent:
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    value: Range
  description:
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        l: sct
      code:
        v: 434472006
      display:
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  time: DateTime
    v: 2025-02-06T09:20:00+01:00
processing:
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BreastResectionSpecimenSlideRR-Superior-HE01
type: Specimen
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text:
  status:
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    v: Generated Narrative: Specimen BreastResectionSpecimenSlideRR-Superior-HE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_3_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_3; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:25:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:25:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:40:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
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      display:
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processing:
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BreastResectionSpecimenSlideRR-Inferior-HE01
type: Specimen
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text:
  status:
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processing:
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      display:
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processing:
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BreastResectionSpecimenSlideRR-Medial-HE01
type: Specimen
id:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
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processing:
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processing:
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BreastResectionSpecimenSlideRR-Lateral-HE01
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
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BreastResectionSpecimenSlideRR-Posterior-HE01
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
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    v: extensions
  div:
    v: Generated Narrative: Specimen BreastResectionSpecimenSlideRR-Posterior-HE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_7_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:37:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:37:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:52:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210_A_7_1_HE_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_210
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: BreastResectionSpecimenBlock07
  reference:
    v: Specimen/BreastResectionSpecimenBlock07
collection:
  collected: DateTime
    v: 2025-02-06T09:37:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:37:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:52:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

BreastResectionSubstanceER
type: Substance
id:
  v: BreastResectionSubstanceER
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstanceER Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Estrogen Receptor (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Estrogen Receptor (Dako Omnis)

BreastResectionSubstancePR
type: Substance
id:
  v: BreastResectionSubstancePR
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstancePR Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Progesterone Receptor (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Progesterone Receptor (Dako Omnis)

BreastResectionSubstanceHER2IHC
type: Substance
id:
  v: BreastResectionSubstanceHER2IHC
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstanceHER2IHC Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: VENTANA HER2 (4B5), Roche
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: VENTANA HER2 (4B5), Roche

BreastResectionSubstanceKi67
type: Substance
id:
  v: BreastResectionSubstanceKi67
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstanceKi67 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Ki-67 Antigen (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Ki-67 Antigen (Dako Omnis)

BreastResectionSubstanceCK18
type: Substance
id:
  v: BreastResectionSubstanceCK18
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstanceCK18 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Cytokeratin 18 (DC10), Dako Omnis
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Cytokeratin 18 (DC10), Dako Omnis

BreastResectionSubstancep40
type: Substance
id:
  v: BreastResectionSubstancep40
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstancep40 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: p40 (BC28), Biocare Medical
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: p40 (BC28), Biocare Medical

BreastResectionSubstanceECadherin
type: Substance
id:
  v: BreastResectionSubstanceECadherin
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance BreastResectionSubstanceECadherin Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: E-Cadherin (NCH-38), Dako Omnis
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: E-Cadherin (NCH-38), Dako Omnis

BreastResectionMacroscopicGrouper
type: Observation
id:
  v: BreastResectionMacroscopicGrouper
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroscopicGrouper Profile: MII PR Patho Macroscopic Grouper version: 2026.0.0 status: Final category: Laboratory code: Pathology report gross observation Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann bodySite: Breast structure (body structure) hasMember: Observation Specimen size.maximum dimension in Breast tumor Observation Specimen size additional dimension 1 in Breast tumor Observation Specimen size additional dimension 2 in Breast tumor Observation Specimen wt Tiss Qn Observation Quadrant Breast Observation Radial position in breast [Angle] in Breast cancer specimen Observation Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity) Observation Number of paraffin embedded tissue blocks examined from excised specimen (observable entity) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
code:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
has member:
  l: BreastResectionMacroLength
  reference:
    v: Observation/BreastResectionMacroLength
has member:
  l: BreastResectionMacroWidth
  reference:
    v: Observation/BreastResectionMacroWidth
has member:
  l: BreastResectionMacroDepth
  reference:
    v: Observation/BreastResectionMacroDepth
has member:
  l: BreastResectionMacroWeight
  reference:
    v: Observation/BreastResectionMacroWeight
has member:
  l: BreastResectionMacroQuadrant
  reference:
    v: Observation/BreastResectionMacroQuadrant
has member:
  l: BreastResectionMacroClock
  reference:
    v: Observation/BreastResectionMacroClock
has member:
  l: BreastResectionMacroDistanceNipple
  reference:
    v: Observation/BreastResectionMacroDistanceNipple
has member:
  l: BreastResectionMacroBlockCount
  reference:
    v: Observation/BreastResectionMacroBlockCount
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroLength
type: Observation
id:
  v: BreastResectionMacroLength
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroLength Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße1 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 42 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44629-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44629-4
    display:
      v: Specimen size.maximum dimension in Breast tumor
  text:
    v: ProbeGröße1
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 42
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroWidth
type: Observation
id:
  v: BreastResectionMacroWidth
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroWidth Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße2 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 35 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44630-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44630-2
    display:
      v: Specimen size additional dimension 1 in Breast tumor
  text:
    v: ProbeGröße2
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 35
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroDepth
type: Observation
id:
  v: BreastResectionMacroDepth
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroDepth Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße3 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 18 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44631-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44631-0
    display:
      v: Specimen size additional dimension 2 in Breast tumor
  text:
    v: ProbeGröße3
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 18
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroWeight
type: Observation
id:
  v: BreastResectionMacroWeight
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroWeight Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Gewicht der Probe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 10 g (Details: UCUM codeg = 'g') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/29638-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 29638-4
    display:
      v: Specimen wt Tiss Qn
  text:
    v: Gewicht der Probe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 10
  unit:
    v: g
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: g
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroQuadrant
type: Observation
id:
  v: BreastResectionMacroQuadrant
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroQuadrant Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Quadrantenlokalisaion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: Unterer äußerer Quadrant specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/42799-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 42799-7
    display:
      v: Quadrant Breast
  text:
    v: Quadrantenlokalisaion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/33564002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 33564002
    display:
      v: Structure of lower outer quadrant of breast (body structure)
  text:
    v: Unterer äußerer Quadrant
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroClock
type: Observation
id:
  v: BreastResectionMacroClock
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroClock Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Zifferblattlokalisation subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 5 o'clock (Details: UCUM code{clock position} = '{clock position}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/85332-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85332-5
    display:
      v: Radial position in breast [Angle] in Breast cancer specimen
  coding: http://snomed.info/id/3980001000004105
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3980001000004105
    display:
      v: Radial location of primary malignant neoplasm in excised breast specimen (observable entity)
  text:
    v: Zifferblattlokalisation
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 5
  unit:
    v: o'clock
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {clock position}
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroDistanceNipple
type: Observation
id:
  v: BreastResectionMacroDistanceNipple
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroDistanceNipple Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Abstand von der Mamille subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 50 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/1240401000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240401000
    display:
      v: Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity)
  text:
    v: Abstand von der Mamille
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 50
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMacroBlockCount
type: Observation
id:
  v: BreastResectionMacroBlockCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMacroBlockCount Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Anzahl Paraffinblöcke subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 6 Blöcke (Details: UCUM code{blocks} = '{blocks}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/3100001000004109
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3100001000004109
    display:
      v: Number of paraffin embedded tissue blocks examined from excised specimen (observable entity)
  text:
    v: Anzahl Paraffinblöcke
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 6
  unit:
    v: Blöcke
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {blocks}
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionDiagnosticConclusionGrouper
type: Observation
id:
  v: BreastResectionDiagnosticConclusionGrouper
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionDiagnosticConclusionGrouper Profile: MII PR Patho Diagnostic Conclusion Grouper version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory code: Pathology report final diagnosis Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann hasMember: Observation Surgery procedure Observation Specimen type Observation Specimen laterality (observable entity) Observation Body structure included in specimen [Anatomy] in Specimen Observation Qualitative distribution of primary malignant neoplasm of breast in excised breast specimen (observable entity) Observation Inv comp size max dim BT Observation Size.maximum dimension in Tumor Observation Histo type BT Observation Histology type in Cancer specimen Narrative Observation Nottingham combined grade of primary malignant neoplasm of breast (observable entity) Observation Nottingham total score of primary malignant neoplasm of breast (observable entity) Observation Number of mitoses per 10 high power fields (observable entity) Observation DCIS intraduct ext Br ca spec Ql Micro Observation Nuclear grade of ductal carcinoma in situ of breast (observable entity) Observation Growth pattern of DCIS [Type] in Breast cancer specimen by Light microscopy Observation DCIS necrosis [Type] in Breast cancer specimen by Light microscopy Observation Adjacent structure invaded by tumor [Anatomy] in Breast cancer specimen by Light microscopy Observation Margin involved BT Observation IC uninv marg closest BT Observation IC uninv marg dist closest BT Observation Surgical margin DCIS involvement [Presence] in Breast cancer specimen by Light microscopy Observation DCIS.uninv marg dist.closest BT Observation Lymph-vascular invasion Ca spec Observation Presence of microcalcification in excised breast specimen (observable entity) Observation E…
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
code:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
has member:
  l: BreastResectionOperativeProcedure
  reference:
    v: Observation/BreastResectionOperativeProcedure
has member:
  l: BreastResectionMaterialType
  reference:
    v: Observation/BreastResectionMaterialType
has member:
  l: BreastResectionLaterality
  reference:
    v: Observation/BreastResectionLaterality
has member:
  l: BreastResectionAttachedTissue
  reference:
    v: Observation/BreastResectionAttachedTissue
has member:
  l: BreastResectionFocality
  reference:
    v: Observation/BreastResectionFocality
has member:
  l: BreastResectionMaxDiameterInvasive
  reference:
    v: Observation/BreastResectionMaxDiameterInvasive
has member:
  l: BreastResectionMaxOverallDiameter
  reference:
    v: Observation/BreastResectionMaxOverallDiameter
has member:
  l: BreastResectionHistologicalType
  reference:
    v: Observation/BreastResectionHistologicalType
has member:
  l: BreastResectionMorphologyFreeText
  reference:
    v: Observation/BreastResectionMorphologyFreeText
has member:
  l: BreastResectionNottinghamGrade
  reference:
    v: Observation/BreastResectionNottinghamGrade
has member:
  l: BreastResectionNottinghamSummaryScore
  reference:
    v: Observation/BreastResectionNottinghamSummaryScore
has member:
  l: BreastResectionMitosisCount
  reference:
    v: Observation/BreastResectionMitosisCount
has member:
  l: BreastResectionAssociatedDCIS
  reference:
    v: Observation/BreastResectionAssociatedDCIS
has member:
  l: BreastResectionDCISGrade
  reference:
    v: Observation/BreastResectionDCISGrade
has member:
  l: BreastResectionDCISArchitecture
  reference:
    v: Observation/BreastResectionDCISArchitecture
has member:
  l: BreastResectionDCISNecrosis
  reference:
    v: Observation/BreastResectionDCISNecrosis
has member:
  l: BreastResectionTumorExtent
  reference:
    v: Observation/BreastResectionTumorExtent
has member:
  l: BreastResectionMarginStatusInvasive
  reference:
    v: Observation/BreastResectionMarginStatusInvasive
has member:
  l: BreastResectionClosestMargin
  reference:
    v: Observation/BreastResectionClosestMargin
has member:
  l: BreastResectionMinDistanceInvasive
  reference:
    v: Observation/BreastResectionMinDistanceInvasive
has member:
  l: BreastResectionMarginStatusNonInvasive
  reference:
    v: Observation/BreastResectionMarginStatusNonInvasive
has member:
  l: BreastResectionMinDistanceNonInvasive
  reference:
    v: Observation/BreastResectionMinDistanceNonInvasive
has member:
  l: BreastResectionLVI
  reference:
    v: Observation/BreastResectionLVI
has member:
  l: BreastResectionMicrocalcification
  reference:
    v: Observation/BreastResectionMicrocalcification
has member:
  l: BreastResectionERStatus
  reference:
    v: Observation/BreastResectionERStatus
has member:
  l: BreastResectionERPercentage
  reference:
    v: Observation/BreastResectionERPercentage
has member:
  l: BreastResectionERIntensity
  reference:
    v: Observation/BreastResectionERIntensity
has member:
  l: BreastResectionPRStatus
  reference:
    v: Observation/BreastResectionPRStatus
has member:
  l: BreastResectionPRPercentage
  reference:
    v: Observation/BreastResectionPRPercentage
has member:
  l: BreastResectionPRIntensity
  reference:
    v: Observation/BreastResectionPRIntensity
has member:
  l: BreastResectionHER2IHC
  reference:
    v: Observation/BreastResectionHER2IHC
has member:
  l: BreastResectionHER2ISH
  reference:
    v: Observation/BreastResectionHER2ISH
has member:
  l: BreastResectionHER2Overall
  reference:
    v: Observation/BreastResectionHER2Overall
has member:
  l: BreastResectionKi67
  reference:
    v: Observation/BreastResectionKi67
has member:
  l: BreastResectionPT
  reference:
    v: Observation/BreastResectionPT
has member:
  l: BreastResectionComment
  reference:
    v: Observation/BreastResectionComment
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionOperativeProcedure
type: Observation
id:
  v: BreastResectionOperativeProcedure
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionOperativeProcedure Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Operatives Verfahren subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Brusterhaltende Therapie (BET) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/29306-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 29306-8
    display:
      v: Surgery procedure
  coding: http://snomed.info/id/2620001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2620001000004108
    display:
      v: Specimen collection procedure (observable entity)
  text:
    v: Operatives Verfahren
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/237371007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 237371007
    display:
      v: Wide local excision of breast lesion (procedure)
  text:
    v: Brusterhaltende Therapie (BET)
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMaterialType
type: Observation
id:
  v: BreastResectionMaterialType
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMaterialType Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Materialart subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Exzisionspräparat specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/66746-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 66746-9
    display:
      v: Specimen type
  text:
    v: Materialart
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/309546004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 309546004
    display:
      v: Lumpectomy breast specimen (specimen)
  text:
    v: Exzisionspräparat
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionLaterality
type: Observation
id:
  v: BreastResectionLaterality
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionLaterality Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Seitenlokalisation der Probe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Links specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/384727002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 384727002
    display:
      v: Specimen laterality (observable entity)
  text:
    v: Seitenlokalisation der Probe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/7771000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 7771000
    display:
      v: Left (qualifier value)
  text:
    v: Links
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionAttachedTissue
type: Observation
id:
  v: BreastResectionAttachedTissue
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionAttachedTissue Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Material/anhängendes Gewebe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Haut specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85298-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85298-8
    display:
      v: Body structure included in specimen [Anatomy] in Specimen
  text:
    v: Material/anhängendes Gewebe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/39937001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 39937001
    display:
      v: Skin structure (body structure)
  text:
    v: Haut
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionFocality
type: Observation
id:
  v: BreastResectionFocality
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionFocality Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: (Multi)fokalität subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Unifokal specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1157128007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1157128007
    display:
      v: Qualitative distribution of primary malignant neoplasm of breast in excised breast specimen (observable entity)
  text:
    v: (Multi)fokalität
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Unifokal
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMaxDiameterInvasive
type: Observation
id:
  v: BreastResectionMaxDiameterInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMaxDiameterInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Maximaler Durchmesser invasives Karzinom subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 18 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44635-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44635-1
    display:
      v: Inv comp size max dim BT
  coding: http://snomed.info/id/200001000004104
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 200001000004104
    display:
      v: Greatest length dimension of excised primary malignant neoplasm (observable entity)
  text:
    v: Maximaler Durchmesser invasives Karzinom
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 18
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMaxOverallDiameter
type: Observation
id:
  v: BreastResectionMaxOverallDiameter
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMaxOverallDiameter Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Maximaler Gesamtdurchmesser der Läsion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 22 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/33728-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33728-7
    display:
      v: Size.maximum dimension in Tumor
  text:
    v: Maximaler Gesamtdurchmesser der Läsion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 22
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionHistologicalType
type: Observation
id:
  v: BreastResectionHistologicalType
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionHistologicalType Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histologischer Tumortyp WHO subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Invasives duktales Karzinom (NST) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44638-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44638-5
    display:
      v: Histo type BT
  coding: http://snomed.info/id/1660001000004100
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1660001000004100
    display:
      v: Histologic type of primary malignant neoplasm of breast (observable entity)
  text:
    v: Histologischer Tumortyp WHO
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/82711006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 82711006
    display:
      v: Infiltrating duct carcinoma (morphologic abnormality)
  text:
    v: Invasives duktales Karzinom (NST)
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMorphologyFreeText
type: Observation
id:
  v: BreastResectionMorphologyFreeText
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMorphologyFreeText Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Morphologie Freitext subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion. specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/33731-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33731-1
    display:
      v: Histology type in Cancer specimen Narrative
  text:
    v: Morphologie Freitext
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion.
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionNottinghamGrade
type: Observation
id:
  v: BreastResectionNottinghamGrade
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionNottinghamGrade Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histologischer Tumorgrad (Nottingham-Grad) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nottingham Grad 2 specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Observation Nottingham total score of primary malignant neoplasm of breast (observable entity)
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/372276001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 372276001
    display:
      v: Nottingham combined grade of primary malignant neoplasm of breast (observable entity)
  text:
    v: Histologischer Tumorgrad (Nottingham-Grad)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/1155703007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1155703007
    display:
      v: G2: Moderately differentiated histologic grade (qualifier value)
  text:
    v: Nottingham Grad 2
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
derived from:
  l: BreastResectionNottinghamSummaryScore
  reference:
    v: Observation/BreastResectionNottinghamSummaryScore

BreastResectionNottinghamSummaryScore
type: Observation
id:
  v: BreastResectionNottinghamSummaryScore
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionNottinghamSummaryScore Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Elston-Ellis-Summenscore subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 6 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' component code: Glandular differentiation [Score] in Breast cancer specimen by Nottingham value: 3 score (Details: UCUM code{score} = '{score}') component code: Nuclear pleomorphism in Breast tumor by Nottingham value: 2 score (Details: UCUM code{score} = '{score}') component code: Mitotic rate [Score] in Breast cancer specimen by Nottingham value: 1 score (Details: UCUM code{score} = '{score}')
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1287461000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1287461000
    display:
      v: Nottingham total score of primary malignant neoplasm of breast (observable entity)
  text:
    v: Elston-Ellis-Summenscore
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 6
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/85321-8
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 85321-8
      display:
        v: Glandular differentiation [Score] in Breast cancer specimen by Nottingham
  value: Quantity
    value:
      v: 3
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}
component:
  code:
    coding: https://loinc.org/rdf/44645-0
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 44645-0
      display:
        v: Nuclear pleomorphism in Breast tumor by Nottingham
  value: Quantity
    value:
      v: 2
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}
component:
  code:
    coding: https://loinc.org/rdf/85300-2
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 85300-2
      display:
        v: Mitotic rate [Score] in Breast cancer specimen by Nottingham
  value: Quantity
    value:
      v: 1
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}

BreastResectionMitosisCount
type: Observation
id:
  v: BreastResectionMitosisCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMitosisCount Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mitosezahl subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 4 per 10 HPF (Details: UCUM code{HPF} = '{HPF}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/406094009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 406094009
    display:
      v: Number of mitoses per 10 high power fields (observable entity)
  text:
    v: Mitosezahl
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 4
  unit:
    v: per 10 HPF
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {HPF}
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionAssociatedDCIS
type: Observation
id:
  v: BreastResectionAssociatedDCIS
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionAssociatedDCIS Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Klassifikation eines assoziiertes DCIS subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: DCIS vorhanden, ohne extensive intraduktale Komponente (EIC) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85336-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85336-6
    display:
      v: DCIS intraduct ext Br ca spec Ql Micro
  text:
    v: Klassifikation eines assoziiertes DCIS
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA27260-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA27260-1
    display:
      v: DCIS present without extensive intraductal component (EIC)
  text:
    v: DCIS vorhanden, ohne extensive intraduktale Komponente (EIC)
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionDCISGrade
type: Observation
id:
  v: BreastResectionDCISGrade
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionDCISGrade Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Kerngrading / WHO-Grading nichtinvasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Intermediär (Grad 2) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/2890001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2890001000004108
    display:
      v: Nuclear grade of ductal carcinoma in situ of breast (observable entity)
  text:
    v: Kerngrading / WHO-Grading nichtinvasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/369782002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 369782002
    display:
      v: Ductal carcinoma in situ nuclear pleomorphism, grade 2: neither nuclear grade 1 nor nuclear grade 3 (finding)
  text:
    v: Intermediär (Grad 2)
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionDCISArchitecture
type: Observation
id:
  v: BreastResectionDCISArchitecture
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionDCISArchitecture Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: DCIS Architektur subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: kribriformer Typ specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85302-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85302-8
    display:
      v: Growth pattern of DCIS [Type] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/3400001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3400001000004108
    display:
      v: Architectural pattern of ductal carcinoma in situ in breast (observable entity)
  text:
    v: DCIS Architektur
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/443987001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 443987001
    display:
      v: Cribriform neoplasm pattern (finding)
  text:
    v: kribriformer Typ
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionDCISNecrosis
type: Observation
id:
  v: BreastResectionDCISNecrosis
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionDCISNecrosis Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Nekrosen subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Zentral (Komedo-Nekrosen) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85340-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85340-8
    display:
      v: DCIS necrosis [Type] in Breast cancer specimen by Light microscopy
  text:
    v: Nekrosen
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA27235-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA27235-3
    display:
      v: Present, central (expansive "comedo" necrosis)
  text:
    v: Zentral (Komedo-Nekrosen)
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionTumorExtent
type: Observation
id:
  v: BreastResectionTumorExtent
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionTumorExtent Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Tumorausdehnung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Auf Brustdrüse beschränkt specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85322-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85322-6
    display:
      v: Adjacent structure invaded by tumor [Anatomy] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/396645007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 396645007
    display:
      v: Status of extension by tumor (observable entity)
  coding: http://snomed.info/id/3280001000004106
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3280001000004106
    display:
      v: Anatomic location directly invaded by primary malignant neoplasm of breast (observable entity)
  text:
    v: Tumorausdehnung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/372288004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 372288004
    display:
      v: Local tumor invasion (finding)
  text:
    v: Auf Brustdrüse beschränkt
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMarginStatusInvasive
type: Observation
id:
  v: BreastResectionMarginStatusInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMarginStatusInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Resektionsrandstatus invasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht befallen (R0) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44669-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44669-0
    display:
      v: Margin involved BT
  coding: http://snomed.info/id/371488000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371488000
    display:
      v: Presence of neoplasm at excised surgical margin (observable entity)
  coding: http://snomed.info/id/1240395000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240395000
    display:
      v: Surgical margin involved by primary malignant neoplasm of breast in excised breast specimen (observable entity)
  text:
    v: Resektionsrandstatus invasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht befallen (R0)
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionClosestMargin
type: Observation
id:
  v: BreastResectionClosestMargin
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionClosestMargin Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Richtung des nächsten tumorfreien RR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Posterior specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44674-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44674-0
    display:
      v: IC uninv marg closest BT
  coding: http://snomed.info/id/170001000004107
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 170001000004107
    display:
      v: Surgical margin closest to malignant neoplasm in excised specimen of breast (observable entity)
  text:
    v: Richtung des nächsten tumorfreien RR
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/255551008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 255551008
    display:
      v: Posterior (qualifier value)
  text:
    v: Posterior
specimen:
  l: BreastResectionSpecimenSlideRR-Posterior-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Posterior-HE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMinDistanceInvasive
type: Observation
id:
  v: BreastResectionMinDistanceInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMinDistanceInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mindestabstand des invasiven Tumor zum nächstgelegenen Resektionsrand subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 5 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44672-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44672-4
    display:
      v: IC uninv marg dist closest BT
  coding: http://snomed.info/id/373120008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 373120008
    display:
      v: Distance of invasive carcinoma of breast from closest surgical margin in excised breast specimen (observable entity)
  text:
    v: Mindestabstand des invasiven Tumor zum nächstgelegenen Resektionsrand
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 5
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: BreastResectionSpecimenSlideRR-Posterior-HE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideRR-Posterior-HE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMarginStatusNonInvasive
type: Observation
id:
  v: BreastResectionMarginStatusNonInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMarginStatusNonInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Resektionsrandstatus nichtinvasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht befallen derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85334-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85334-1
    display:
      v: Surgical margin DCIS involvement [Presence] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/384705006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 384705006
    display:
      v: Presence of ductal carcinoma in situ at surgical margin in excised specimen of breast (observable entity)
  text:
    v: Resektionsrandstatus nichtinvasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht befallen
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMinDistanceNonInvasive
type: Observation
id:
  v: BreastResectionMinDistanceNonInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMinDistanceNonInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mindestabstand vom RR zum nichtinvasiven Tumor subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 3 mm (Details: UCUM codemm = 'mm') derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44673-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44673-2
    display:
      v: DCIS.uninv marg dist.closest BT
  text:
    v: Mindestabstand vom RR zum nichtinvasiven Tumor
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 3
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionLVI
type: Observation
id:
  v: BreastResectionLVI
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionLVI Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Peritumorale Gefäßinvasion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht nachgewiesen specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/59544-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 59544-7
    display:
      v: Lymph-vascular invasion Ca spec
  coding: http://snomed.info/id/371512006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371512006
    display:
      v: Presence of direct invasion by primary malignant neoplasm to lymphatic vessel and/or small blood vessel (observable entity)
  text:
    v: Peritumorale Gefäßinvasion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht nachgewiesen
specimen:
  l: BreastResectionSpecimenPart
  reference:
    v: Specimen/BreastResectionSpecimenPart
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionMicrocalcification
type: Observation
id:
  v: BreastResectionMicrocalcification
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionMicrocalcification Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Presence of microcalcification in excised breast specimen (observable entity) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Microcalcifications present in DCIS specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1240404008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240404008
    display:
      v: Presence of microcalcification in excised breast specimen (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA27826-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA27826-9
    display:
      v: Microcalcifications present in DCIS
specimen:
  l: BreastResectionSpecimenSlideHE01
  reference:
    v: Specimen/BreastResectionSpecimenSlideHE01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

BreastResectionERStatus
type: Observation
id:
  v: BreastResectionERStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionERStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Hormonrezeptorstatus Östrogen subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/16112-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 16112-5
    display:
      v: Estrogen receptor [Interpretation] in Tissue
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Hormonrezeptorstatus Östrogen
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA6576-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA6576-8
    display:
      v: Positive
  text:
    v: Positiv
specimen:
  l: BreastResectionSpecimenSlideER01
  reference:
    v: Specimen/BreastResectionSpecimenSlideER01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

BreastResectionERPercentage
type: Observation
id:
  v: BreastResectionERPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionERPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: PP ER subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 90 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85329-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85329-1
    display:
      v: Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234804006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234804006
    display:
      v: Percent of cells with estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: PP ER
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 90
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: BreastResectionSpecimenSlideER01
  reference:
    v: Specimen/BreastResectionSpecimenSlideER01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

BreastResectionERIntensity
type: Observation
id:
  v: BreastResectionERIntensity
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionERIntensity Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Färbeintensität ER subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Stark specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85310-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85310-1
    display:
      v: Estrogen receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1236874005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1236874005
    display:
      v: Intensity of stain of estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Färbeintensität ER
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/24484000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 24484000
    display:
      v: Severe (severity modifier) (qualifier value)
  text:
    v: Stark
specimen:
  l: BreastResectionSpecimenSlideER01
  reference:
    v: Specimen/BreastResectionSpecimenSlideER01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

BreastResectionPRStatus
type: Observation
id:
  v: BreastResectionPRStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionPRStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Hormonrezeptorstatus Progesteron subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/16113-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 16113-3
    display:
      v: Progesterone receptor [Interpretation] in Tissue
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Hormonrezeptorstatus Progesteron
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA6576-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA6576-8
    display:
      v: Positive
  text:
    v: Positiv
specimen:
  l: BreastResectionSpecimenSlidePR01
  reference:
    v: Specimen/BreastResectionSpecimenSlidePR01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

BreastResectionPRPercentage
type: Observation
id:
  v: BreastResectionPRPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionPRPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: PP PR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 60 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85325-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85325-9
    display:
      v: Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234803000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234803000
    display:
      v: Percent of cells with progesterone receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: PP PR
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 60
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: BreastResectionSpecimenSlidePR01
  reference:
    v: Specimen/BreastResectionSpecimenSlidePR01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

BreastResectionPRIntensity
type: Observation
id:
  v: BreastResectionPRIntensity
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionPRIntensity Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Färbeintensität PR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Mäßig specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1237278006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1237278006
    display:
      v: Intensity of stain of progesterone receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  text:
    v: Färbeintensität PR
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/6736007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 6736007
    display:
      v: Moderate (severity modifier) (qualifier value)
  text:
    v: Mäßig
specimen:
  l: BreastResectionSpecimenSlidePR01
  reference:
    v: Specimen/BreastResectionSpecimenSlidePR01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

BreastResectionHER2IHC
type: Observation
id:
  v: BreastResectionHER2IHC
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionHER2IHC Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Her2 Score subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 1+ specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ERBB2
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85319-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85319-2
    display:
      v: HER2 [Presence] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/3550001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3550001000004108
    display:
      v: Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Her2 Score
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA11841-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA11841-6
    display:
      v: 1+
  text:
    v: 1+
specimen:
  l: BreastResectionSpecimenSlideHER2IHC01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3430
      display:
        v: ERBB2

BreastResectionHER2ISH
type: Observation
id:
  v: BreastResectionHER2ISH
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionHER2ISH Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Her2 Amplifikation subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht amplifiziert specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ERBB2
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1363314005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1363314005
    display:
      v: Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by in situ hybridization (observable entity)
  text:
    v: Her2 Amplifikation
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/705105000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 705105000
    display:
      v: Human epidermal growth factor 2 gene amplification not detected (finding)
  text:
    v: Nicht amplifiziert
specimen:
  l: BreastResectionSpecimenSlideHER2IHC01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3430
      display:
        v: ERBB2

BreastResectionHER2Overall
type: Observation
id:
  v: BreastResectionHER2Overall
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionHER2Overall Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Her2neuStatus subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Negativ specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ERBB2
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/48676-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 48676-1
    display:
      v: HER2 [Interpretation] in Tissue
  text:
    v: Her2neuStatus
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA6577-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA6577-6
    display:
      v: Negative
  text:
    v: Negativ
specimen:
  l: BreastResectionSpecimenSlideHER2IHC01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3430
      display:
        v: ERBB2

BreastResectionKi67
type: Observation
id:
  v: BreastResectionKi67
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionKi67 Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Ki67-Index subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 15 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_Ki67_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] MKI67
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85330-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85330-9
    display:
      v: Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1237281001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1237281001
    display:
      v: Percent of cell nuclei positive for proliferation marker protein Ki-67 in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Ki67-Index
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 15
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: BreastResectionSpecimenSlideKi67-01
  reference:
    v: Specimen/BreastResectionSpecimenSlideKi67-01
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:7107
      display:
        v: MKI67

BreastResectionPT
type: Observation
id:
  v: BreastResectionPT
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-tnm-t-kategorie|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-pr-onko-tnm-t-kategorie
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionPT Profile: MII PR Onkologie TNM T-Kategorie version: 2026.0.0 status: Final code: pT category (observable entity) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 value: T1 method: 8. Auflage
status:
  v: final
code:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/StructureDefinition/mii-ex-onko-tnm-cp-praefix
      l: mii-ex-onko-tnm-cp-praefix
    value: CodeableConcept
  coding: http://snomed.info/id/384625004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 384625004
    display:
      v: pT category (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
value: CodeableConcept
  coding:
    system:
      v: https://www.uicc.org/resources/tnm
      l: tnm
    code:
      v: T1
    display:
      v: T1
method:
  coding:
    system:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-tnm-version
      l: mii-cs-onko-tnm-version
    code:
      v: 8
    display:
      v: 8. Auflage

BreastResectionComment
type: Observation
id:
  v: BreastResectionComment
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation BreastResectionComment Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Kommentar subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: BreastResectionReportRequest
  reference:
    v: ServiceRequest/BreastResectionReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/22638-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22638-1
    display:
      v: Pathology report comments [Interpretation] Narrative
  text:
    v: Kommentar
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung.
derived from:
  l: QuestionnaireResponseBreastResection
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseBreastResection

QuestionnaireResponseBreastResection
type: QuestionnaireResponse
id:
  v: QuestionnaireResponseBreastResection
text:
  status:
    v: generated
  div:
    v: Generated Narrative: QuestionnaireResponse QuestionnaireResponseBreastResection LinkID Text Definition Answer<img src="[binary]" alt="doco" style="background-color: inherit"/> QuestionnaireResponseBreastResection Questionnaire:http://breastcancerspec.org/Questionnaire/OP-Mamma #xD; bet.root BET Mamma #xD; bet.clinical Klinische Angaben #xD; 11951 Proben limitiert auswertbar SNOMED CT: 373067005 (No (qualifier value)) #xD; 11912 Präsentationsmodus Frisch #xD; 11147 Klinische Befunde / Anlass Z.n. Stanzbiopsie mit Nachweis eines invasiven Mammakarzinoms NST, G2 #xD; 11923 Brustkrebsvorgeschichte Ersterkrankung #xD; 11952 Vorchirurgische Therapie SNOMED CT: 373067005 (No (qualifier value)) #xD; 11918 Bildgebungsmodalität Mammografie, Ultraschall #xD; 11953 Radiologische Ausdehnung 15 mm (Details: UCUM codemm = 'mm') #xD; 10160 Befundmarkierung Drahthäkchen #xD; 10130 Präparateradiographie Ja, beigelegt #xD; 11954 Genetische Prädisposition Nicht bekannt #xD; bet.macro Makroskopie #xD; 10900 Probengröße 1 (Länge) 65 mm (Details: UCUM codemm = 'mm') #xD; 10910 Probengröße 2 (Breite) 45 mm (Details: UCUM codemm = 'mm') #xD; 10920 Probengröße 3 (Tiefe) 30 mm (Details: UCUM codemm = 'mm') #xD; 10890 Gewicht 55 g (Details: UCUM codeg = 'g') #xD; 10030 Quadrant SNOMED CT: 33564002 (Structure of lower outer quadrant of breast (body structure)) #xD; 10040 Zifferblattlokalisation 5 Uhr #xD; 10070 Abstand Mamille 50 mm (Details: UCUM codemm = 'mm') #xD; bet.general Allgemeine Befunde #xD; 11130 Nichtinvasive Läsion SNOMED CT: 52101004 (Present (qualifier value)) #xD; 11270 Invasives Karzinom SNOMED CT: 52101004 (Present (qualifier value)) #xD; 11919 Operatives Verfahren SNOMED CT: 237371007 (Wide local excision of breast lesion (procedure)) #xD; 10140 Materialart Exzisionspräparat #xD; 10800 Seitenlokalisation SNOMED CT: 7771000 (Left (qualifier value)) #xD; 11040 Anhängendes Gewebe Haut #xD; 11440 Fokalität Unifokal #xD; bet.invasive Invasives Karzinom #xD; 11400 Max Durchmesser …
questionnaire:
  v: http://breastcancerspec.org/Questionnaire/OP-Mamma
  l: OP-Mamma
status:
  v: completed
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
authored:
  v: 2025-02-10T14:30:00+01:00
author:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
item:
  link id:
    v: bet.root
  text:
    v: BET Mamma
  item:
    link id:
      v: bet.clinical
    text:
      v: Klinische Angaben
    item:
      link id:
        v: 11951
      text:
        v: Proben limitiert auswertbar
      answer:
        value: Coding
    item:
      link id:
        v: 11912
      text:
        v: Präsentationsmodus
      answer:
        value: String
    item:
      link id:
        v: 11147
      text:
        v: Klinische Befunde / Anlass
      answer:
        value: String
    item:
      link id:
        v: 11923
      text:
        v: Brustkrebsvorgeschichte
      answer:
        value: String
    item:
      link id:
        v: 11952
      text:
        v: Vorchirurgische Therapie
      answer:
        value: Coding
    item:
      link id:
        v: 11918
      text:
        v: Bildgebungsmodalität
      answer:
        value: String
    item:
      link id:
        v: 11953
      text:
        v: Radiologische Ausdehnung
      answer:
        value: Quantity
    item:
      link id:
        v: 10160
      text:
        v: Befundmarkierung
      answer:
        value: String
    item:
      link id:
        v: 10130
      text:
        v: Präparateradiographie
      answer:
        value: String
    item:
      link id:
        v: 11954
      text:
        v: Genetische Prädisposition
      answer:
        value: String
  item:
    link id:
      v: bet.macro
    text:
      v: Makroskopie
    item:
      link id:
        v: 10900
      text:
        v: Probengröße 1 (Länge)
      answer:
        value: Quantity
    item:
      link id:
        v: 10910
      text:
        v: Probengröße 2 (Breite)
      answer:
        value: Quantity
    item:
      link id:
        v: 10920
      text:
        v: Probengröße 3 (Tiefe)
      answer:
        value: Quantity
    item:
      link id:
        v: 10890
      text:
        v: Gewicht
      answer:
        value: Quantity
    item:
      link id:
        v: 10030
      text:
        v: Quadrant
      answer:
        value: Coding
    item:
      link id:
        v: 10040
      text:
        v: Zifferblattlokalisation
      answer:
        value: String
    item:
      link id:
        v: 10070
      text:
        v: Abstand Mamille
      answer:
        value: Quantity
  item:
    link id:
      v: bet.general
    text:
      v: Allgemeine Befunde
    item:
      link id:
        v: 11130
      text:
        v: Nichtinvasive Läsion
      answer:
        value: Coding
    item:
      link id:
        v: 11270
      text:
        v: Invasives Karzinom
      answer:
        value: Coding
    item:
      link id:
        v: 11919
      text:
        v: Operatives Verfahren
      answer:
        value: Coding
    item:
      link id:
        v: 10140
      text:
        v: Materialart
      answer:
        value: String
    item:
      link id:
        v: 10800
      text:
        v: Seitenlokalisation
      answer:
        value: Coding
    item:
      link id:
        v: 11040
      text:
        v: Anhängendes Gewebe
      answer:
        value: String

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

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v: 25

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v: Cel

v: 20

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v: 25

v: °C

v: Cel

v: 20

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v: 25

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v: 20

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v: 20

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v: 25

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v: 20

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v: 25

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v: 20

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v: 20

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v: 25

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v: 20

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v: 25

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v: 20

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v: 25

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v: 20

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v: 25

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v: 20

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v: 25

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v: Cel

v: 20

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v: Cel

v: 25

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v: p

v: p

Coding
type: http://snomed.info/id/373067005
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 373067005
display:
  v: No (qualifier value)

String
v: Frisch

String
v: Z.n. Stanzbiopsie mit Nachweis eines invasiven Mammakarzinoms NST, G2

String
v: Ersterkrankung

Coding
type: http://snomed.info/id/373067005
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 373067005
display:
  v: No (qualifier value)

String
v: Mammografie, Ultraschall

Quantity
value:
  v: 15
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

String
v: Drahthäkchen

String
v: Ja, beigelegt

String
v: Nicht bekannt

Quantity
value:
  v: 65
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

Quantity
value:
  v: 45
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

Quantity
value:
  v: 30
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

Quantity
value:
  v: 55
unit:
  v: g
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: g

Coding
type: http://snomed.info/id/33564002
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 33564002
display:
  v: Structure of lower outer quadrant of breast (body structure)

String
v: 5 Uhr

Quantity
value:
  v: 50
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

Coding
type: http://snomed.info/id/52101004
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 52101004
display:
  v: Present (qualifier value)

Coding
type: http://snomed.info/id/52101004
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 52101004
display:
  v: Present (qualifier value)

Coding
type: http://snomed.info/id/237371007
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 237371007
display:
  v: Wide local excision of breast lesion (procedure)

String
v: Exzisionspräparat

Coding
type: http://snomed.info/id/7771000
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 7771000
display:
  v: Left (qualifier value)

String
v: Haut

link id:
  v: 11440
text:
  v: Fokalität
answer:
  value: String
    v: Unifokal

link id:
  v: bet.invasive
text:
  v: Invasives Karzinom
item:
  link id:
    v: 11400
  text:
    v: Max Durchmesser invasiv
  answer:
    value: Quantity
      value:
        v: 18
      unit:
        v: mm
      system:
        v: http://unitsofmeasure.org
        l: unitsofmeasure.org
      code:
        v: mm
item:
  link id:
    v: 11420
  text:
    v: Max Gesamtdurchmesser
  answer:
    value: Quantity
      value:
        v: 22
      unit:
        v: mm
      system:
        v: http://unitsofmeasure.org
        l: unitsofmeasure.org
      code:
        v: mm
item:
  link id:
    v: 11280
  text:
    v: Histologischer Tumortyp
  answer:
    value: Coding
      system:
        v: urn:oid:2.16.840.1.113883.6.43.1
        l: 2.16.840.1.113883.6.43.1
      code:
        v: 8500/3
      display:
        v: Invasives duktales Karzinom (NST)
item:
  link id:
    v: 11290
  text:
    v: Morphologie Freitext
  answer:
    value: String
      v: Invasives Mammakarzinom des NST, überwiegend trabekuläres und solides Wachstumsmuster
item:
  link id:
    v: 11330
  text:
    v: Nottingham-Grad
  answer:
    value: String
      v: G2
item:
  link id:
    v: 11340
  text:
    v: Tubulus-Score
  answer:
    value: Integer
      v: 3
item:
  link id:
    v: 11350
  text:
    v: Kernpleomorphie-Score
  answer:
    value: Integer
      v: 2
item:
  link id:
    v: 11925
  text:
    v: Mitosezahl
  answer:
    value: String
      v: 4/10 HPF
item:
  link id:
    v: 11360
  text:
    v: Mitoserate-Score
  answer:
    value: Integer
      v: 1
item:
  link id:
    v: 11390
  text:
    v: Elston-Ellis-Summenscore
  answer:
    value: Integer
      v: 6
item:
  link id:
    v: 11300
  text:
    v: Assoziiertes DCIS
  answer:
    value: Coding
      type: http://snomed.info/id/52101004
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 52101004
      display:
        v: Present (qualifier value)
item:
  link id:
    v: 149
  text:
    v: DCIS Kerngrading
  answer:
    value: String
      v: Intermediär (Grad 2)
item:
  link id:
    v: 150
  text:
    v: DCIS Architektur
  answer:
    value: String
      v: Kribriform
item:
  link id:
    v: 151
  text:
    v: DCIS Nekrosen
  answer:
    value: String
      v: Fokal (Komedo-Nekrosen)
item:
  link id:
    v: 11926
  text:
    v: Tumorausdehnung
  answer:
    value: String
      v: Auf Brustdrüse beschränkt

link id:
  v: bet.margins
text:
  v: Resektionsränder
item:
  link id:
    v: 11470
  text:
    v: RR-Status invasiv
  answer:
    value: Coding
      type: http://snomed.info/id/2667000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 2667000
      display:
        v: Absent (qualifier value)
item:
  link id:
    v: 11490
  text:
    v: Nächster tumorfreier RR
  answer:
    value: String
      v: Posterior
item:
  link id:
    v: 11480
  text:
    v: Mindestabstand invasiv
  answer:
    value: Quantity
      value:
        v: 5
      unit:
        v: mm
      system:
        v: http://unitsofmeasure.org
        l: unitsofmeasure.org
      code:
        v: mm
item:
  link id:
    v: 11968
  text:
    v: RR-Status nichtinvasiv