CoreNeedleBiopsyDocument
type: Bundle
node role: treeRoot
id:
  v: CoreNeedleBiopsyDocument
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_001
type:
  v: document
timestamp:
  v: 2025-01-17T17:00:00+01:00
entry:
  full url:
    v: http://breastcancerspec.org/Composition/CoreNeedleBiopsyComposition
    l: CoreNeedleBiopsyComposition
  resource: CoreNeedleBiopsyComposition
entry:
  full url:
    v: http://breastcancerspec.org/Patient/Patient4
    l: Patient4
  resource: Patient4
entry:
  full url:
    v: http://breastcancerspec.org/Organization/PathologyLabOrganization
    l: PathologyLabOrganization
  resource: PathologyLabOrganization
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/PathologistPractitioner
    l: PathologistPractitioner
  resource: PathologistPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/BreastSurgeonPractitioner
    l: BreastSurgeonPractitioner
  resource: BreastSurgeonPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Encounter/CoreNeedleBiopsyEncounter
    l: CoreNeedleBiopsyEncounter
  resource: CoreNeedleBiopsyEncounter
entry:
  full url:
    v: http://breastcancerspec.org/Condition/CoreNeedleBiopsyDiagnosisPreOp
    l: CoreNeedleBiopsyDiagnosisPreOp
  resource: CoreNeedleBiopsyDiagnosisPreOp
entry:
  full url:
    v: http://breastcancerspec.org/ServiceRequest/CoreNeedleBiopsyReportRequest
    l: CoreNeedleBiopsyReportRequest
  resource: CoreNeedleBiopsyReportRequest
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/CoreNeedleBiopsyImagingReport
    l: CoreNeedleBiopsyImagingReport
  resource: CoreNeedleBiopsyImagingReport
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/CoreNeedleBiopsyReport
    l: CoreNeedleBiopsyReport
  resource: CoreNeedleBiopsyReport
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenPart
    l: CoreNeedleBiopsySpecimenPart
  resource: CoreNeedleBiopsySpecimenPart
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenBlock01
    l: CoreNeedleBiopsySpecimenBlock01
  resource: CoreNeedleBiopsySpecimenBlock01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHE01
    l: CoreNeedleBiopsySpecimenSlideHE01
  resource: CoreNeedleBiopsySpecimenSlideHE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHE02
    l: CoreNeedleBiopsySpecimenSlideHE02
  resource: CoreNeedleBiopsySpecimenSlideHE02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHE03
    l: CoreNeedleBiopsySpecimenSlideHE03
  resource: CoreNeedleBiopsySpecimenSlideHE03
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHE04
    l: CoreNeedleBiopsySpecimenSlideHE04
  resource: CoreNeedleBiopsySpecimenSlideHE04
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideER01
    l: CoreNeedleBiopsySpecimenSlideER01
  resource: CoreNeedleBiopsySpecimenSlideER01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideER02
    l: CoreNeedleBiopsySpecimenSlideER02
  resource: CoreNeedleBiopsySpecimenSlideER02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlidePR01
    l: CoreNeedleBiopsySpecimenSlidePR01
  resource: CoreNeedleBiopsySpecimenSlidePR01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlidePR02
    l: CoreNeedleBiopsySpecimenSlidePR02
  resource: CoreNeedleBiopsySpecimenSlidePR02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHER2-01
    l: CoreNeedleBiopsySpecimenSlideHER2-01
  resource: CoreNeedleBiopsySpecimenSlideHER2-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideHER2-02
    l: CoreNeedleBiopsySpecimenSlideHER2-02
  resource: CoreNeedleBiopsySpecimenSlideHER2-02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideKi67-01
    l: CoreNeedleBiopsySpecimenSlideKi67-01
  resource: CoreNeedleBiopsySpecimenSlideKi67-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/CoreNeedleBiopsySpecimenSlideKi67-02
    l: CoreNeedleBiopsySpecimenSlideKi67-02
  resource: CoreNeedleBiopsySpecimenSlideKi67-02
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyMacroscopicGrouper
    l: CoreNeedleBiopsyMacroscopicGrouper
  resource: CoreNeedleBiopsyMacroscopicGrouper
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyMacroscopicTotalLength
    l: CoreNeedleBiopsyMacroscopicTotalLength
  resource: CoreNeedleBiopsyMacroscopicTotalLength
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyMacroscopicCylinderCount
    l: CoreNeedleBiopsyMacroscopicCylinderCount
  resource: CoreNeedleBiopsyMacroscopicCylinderCount
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyMacroscopicBlockCount
    l: CoreNeedleBiopsyMacroscopicBlockCount
  resource: CoreNeedleBiopsyMacroscopicBlockCount
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyDiagnosticConclusionGrouper
    l: CoreNeedleBiopsyDiagnosticConclusionGrouper
  resource: CoreNeedleBiopsyDiagnosticConclusionGrouper
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyHistologicalTypeICDO3
    l: CoreNeedleBiopsyHistologicalTypeICDO3
  resource: CoreNeedleBiopsyHistologicalTypeICDO3
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyMorphologyFreeText
    l: CoreNeedleBiopsyMorphologyFreeText
  resource: CoreNeedleBiopsyMorphologyFreeText
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyNottinghamGrade
    l: CoreNeedleBiopsyNottinghamGrade
  resource: CoreNeedleBiopsyNottinghamGrade
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyNottinghamSummaryScore
    l: CoreNeedleBiopsyNottinghamSummaryScore
  resource: CoreNeedleBiopsyNottinghamSummaryScore
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyERStatus
    l: CoreNeedleBiopsyERStatus
  resource: CoreNeedleBiopsyERStatus
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyERPercentage
    l: CoreNeedleBiopsyERPercentage
  resource: CoreNeedleBiopsyERPercentage
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyPRStatus
    l: CoreNeedleBiopsyPRStatus
  resource: CoreNeedleBiopsyPRStatus
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyPRPercentage
    l: CoreNeedleBiopsyPRPercentage
  resource: CoreNeedleBiopsyPRPercentage
entry:
  full url:
    v: http://breastcancerspec.org/Observation/CoreNeedleBiopsyHER2ISH
    l: CoreNeedleBiopsyHER2ISH
  resource: CoreNeedleBiopsyHER2ISH

CoreNeedleBiopsyComposition
type: Composition
id:
  v: CoreNeedleBiopsyComposition
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Composition CoreNeedleBiopsyComposition identifier: Accession ID/PATH-COMP-2025-105 status: Final type: Tissue pathology biopsy report (record artifact) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_105; status = finished; class = AMB (AMB) date: 2025-01-17 17:00:00+0100 author: Institut für Pathologie title: Histopathologischer Befundbericht - Stanzbiopsie Mamma links Attesters - Mode Party * Legal Organization Institut für Pathologie custodian: Organization Institut für Pathologie Events - Code Detail * pathology report entry task ServiceRequest Breast Pathology biopsy report
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: http://example.hospital.de/pathology-reports
    l: pathology-reports
  value:
    v: PATH-COMP-2025-105
status:
  v: final
type:
  coding:
    system:
      v: http://ihe-d.de/CodeSystems/IHEXDStypeCode
      l: IHEXDStypeCode
    code:
      v: PATH
  coding: http://snomed.info/id/721967005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 721967005
    display:
      v: Tissue pathology biopsy report (record artifact)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
  display:
    v: Sabine Becker, geb. 15.03.1971 (PAT-2025-105)
encounter:
  l: CoreNeedleBiopsyEncounter
  reference:
    v: Encounter/CoreNeedleBiopsyEncounter
date:
  v: 2025-01-17T17:00:00+01:00
author:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
  display:
    v: Institut für Pathologie
title:
  v: Histopathologischer Befundbericht - Stanzbiopsie Mamma links
attester:
  mode:
    v: legal
  party:
    l: PathologyLabOrganization
    reference:
      v: Organization/PathologyLabOrganization
custodian:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
event:
  code:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v3-ActCode
        l: v3-ActCode
      code:
        v: PATREPE
  detail:
    l: CoreNeedleBiopsyReportRequest
    reference:
      v: ServiceRequest/CoreNeedleBiopsyReportRequest
section:
  title:
    v: Pathologiebefundbericht
  code:
    coding: https://loinc.org/rdf/11526-1
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 11526-1
      display:
        v: Pathology study
  text:
    status:
      v: additional
    div:
      v: Klinische Angaben Herdbefund/Architekturstörung linke Brust, BI-RADS 4b. US-gestützte Stanzbiopsie. Material HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille Makroskopie Stanzzylinder 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke Paraffinblöcke 1 Mikroskopie In beiden vollständig gebetteten, mit jeweils vier Schnittstufen aufgearbeiteten Punktionszylindern lipomatös und fibrolipomatös transformiertes Brustdrüsengewebe, das zu großen Teilen eingenommen wird von Tumorstrukturen eines mittelgroßzelligen, vordergründig trabekulär, solid und dissolut einzelzellig wachsenden invasiven Mammakarzinoms mit mäßiger Zell- und Kernpolymorphie sowie ganz vereinzelt nachweisbaren Mitosen (weniger als 5/10 HPF). Im Tumorzentrum unterschiedlich ausgeprägte Stromasklerose und herdförmige -elastose. An der Tumorperipherie schüttere bis mitteldichte rundzellig entzündliche Stromareaktion. Diagnostische Schlussfolgerung Diagnose: Invasives Mammakarzinom NST (ICD-O 8500/3) ICD-O-3 Morphologie M8500/3 Nottingham-Grad Grad 2 (Score 6: Tubuli 3, Pleomorphie 2, Mitosen 1) ER Positiv (85% positive Tumorzellkerne) PR Positiv (50% positive Tumorzellkerne) HER2 Negativ (nicht amplifiziert) Ki-67 10% B-Klassifikation B5b (NHSBSP) Relevante Mikroverkalkungen Nein Präparateradiogramm Gesehen Korrelation Mikroverkalkung Vorliegende Verkalkung radiologisch nicht relevant (kleiner 100 Mikrometer)
  entry:
    l: CoreNeedleBiopsyReport
    reference:
      v: DiagnosticReport/CoreNeedleBiopsyReport

Patient4
type: Patient
id:
  v: Patient4
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Patient Patient4 Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/patient-ids
    l: patient-ids
  value:
    v: PAT-2025-105
name:
  family:
    v: Becker
  given:
    v: Sabine
gender:
  v: female
birth date:
  v: 1971-03-15

PathologyLabOrganization
type: Organization
id:
  v: PathologyLabOrganization
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Organization PathologyLabOrganization identifier: http://example.hospital.de/organization-ids/ORG-PATH-001 name: Institut für Pathologie
identifier:
  system:
    v: http://example.hospital.de/organization-ids
    l: organization-ids
  value:
    v: ORG-PATH-001
name:
  v: Institut für Pathologie

PathologistPractitioner
type: Practitioner
id:
  v: PathologistPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner PathologistPractitioner identifier: http://example.hospital.de/practitioner-ids/PATH-001 name: Elisabeth Hoffmann Qualifications - Code * Pathology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: PATH-001
name:
  family:
    v: Hoffmann
  given:
    v: Elisabeth
  prefix:
    v: Dr.
qualification:
  code:
    coding: http://snomed.info/id/394595002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394595002
      display:
        v: Pathology

BreastSurgeonPractitioner
type: Practitioner
id:
  v: BreastSurgeonPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner BreastSurgeonPractitioner identifier: http://example.hospital.de/practitioner-ids/GYN-001 name: Thomas Richter Qualifications - Code * Gynecology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: GYN-001
name:
  family:
    v: Richter
  given:
    v: Thomas
  prefix:
    v: Prof. Dr.
qualification:
  code:
    coding: http://snomed.info/id/394586005
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394586005
      display:
        v: Gynecology

CoreNeedleBiopsyEncounter
type: Encounter
id:
  v: CoreNeedleBiopsyEncounter
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Encounter CoreNeedleBiopsyEncounter identifier: http://example.hospital.de/encounters/E_25_105 status: Finished class: [not stated]: AMB (AMB) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/encounters
    l: encounters
  value:
    v: E_25_105
status:
  v: finished
class:
  code:
    v: AMB
subject:
  l: Patient4
  reference:
    v: Patient/Patient4

CoreNeedleBiopsyDiagnosisPreOp
type: Condition
id:
  v: CoreNeedleBiopsyDiagnosisPreOp
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Condition CoreNeedleBiopsyDiagnosisPreOp Profile: MII PR Diagnose Condition version: 2026.0.0 clinicalStatus: Active verificationStatus: Provisional category: Encounter Diagnosis code: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_105; status = finished; class = AMB (AMB) onset: 2025-01-10 recordedDate: 2025-01-10 note: Herdbefund/Architekturstörung linke Brust, BI-RADS 4b. Indikation zur US-gestützten Stanzbiopsie.
clinical status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-clinical
      l: condition-clinical
    code:
      v: active
verification status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-ver-status
      l: condition-ver-status
    code:
      v: provisional
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-category
      l: condition-category
    code:
      v: encounter-diagnosis
code:
  coding:
    system:
      v: http://fhir.de/CodeSystem/bfarm/icd-10-gm
      l: icd-10-gm
    version:
      v: 2025
    code:
      v: C50.5
    display:
      v: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: CoreNeedleBiopsyEncounter
  reference:
    v: Encounter/CoreNeedleBiopsyEncounter
onset: DateTime
  v: 2025-01-10
recorded date:
  v: 2025-01-10
note:
  text:
    v: Herdbefund/Architekturstörung linke Brust, BI-RADS 4b. Indikation zur US-gestützten Stanzbiopsie.

CoreNeedleBiopsyReportRequest
type: ServiceRequest
id:
  v: CoreNeedleBiopsyReportRequest
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request
text:
  status:
    v: generated
  div:
    v: Generated Narrative: ServiceRequest CoreNeedleBiopsyReportRequest Profile: MII PR Patho Service Request version: 2026.0.0 identifier: Placer Identifier/PATH-RPT-2025-105 status: Completed intent: Order category: Pathology consultation, comprehensive, records and specimen with report (procedure) code: Breast Pathology biopsy report subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_105; status = finished; class = AMB (AMB) requester: Practitioner Thomas Richter performer: Practitioner Elisabeth Hoffmann reasonCode: Mammographic architectural distortion of breast (finding) supportingInfo: Diagnostic Report for 'MG Breast Screening' for '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Specimen from breast obtained by core needle biopsy (specimen); note = HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
      display:
        v: Placer Identifier
  system:
    v: http://example.hospital.de/serviceRequest
    l: serviceRequest
  value:
    v: PATH-RPT-2025-105
status:
  v: completed
intent:
  v: order
category:
  coding: http://snomed.info/id/726007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 726007
    display:
      v: Pathology consultation, comprehensive, records and specimen with report (procedure)
code:
  coding: https://loinc.org/rdf/66110-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 66110-8
    display:
      v: Breast Pathology biopsy report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: CoreNeedleBiopsyEncounter
  reference:
    v: Encounter/CoreNeedleBiopsyEncounter
requester:
  l: BreastSurgeonPractitioner
  reference:
    v: Practitioner/BreastSurgeonPractitioner
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
reason code:
  coding: http://snomed.info/id/129792006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 129792006
    display:
      v: Mammographic architectural distortion of breast (finding)
supporting info:
  l: CoreNeedleBiopsyImagingReport
  reference:
    v: DiagnosticReport/CoreNeedleBiopsyImagingReport
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart

CoreNeedleBiopsyImagingReport
type: DiagnosticReport
id:
  v: CoreNeedleBiopsyImagingReport
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport CoreNeedleBiopsyImagingReport MG Breast Screening (Radiology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-01-08 Report Details BI-RADS 4b: Herdbefund/Architekturstörung linke Brust, 5 Uhr, 5 cm von Mamille. Indikation zur histologischen Abklärung mittels Stanzbiopsie.
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: RAD
    display:
      v: Radiology
code:
  coding: https://loinc.org/rdf/24606-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 24606-6
    display:
      v: MG Breast Screening
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-08
conclusion:
  v: BI-RADS 4b: Herdbefund/Architekturstörung linke Brust, 5 Uhr, 5 cm von Mamille. Indikation zur histologischen Abklärung mittels Stanzbiopsie.

CoreNeedleBiopsyReport
type: DiagnosticReport
id:
  v: CoreNeedleBiopsyReport
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport CoreNeedleBiopsyReport Profile: MII PR Patho Report version: 2026.0.0 Pathology Synoptic report (Surgical Pathology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-01-17 15:00:00+0100 Reported 2025-01-17 17:00:00+0100 Performer Practitioner Elisabeth Hoffmann Identifier Accession ID/E_25_105 Report Details Code Value Flags When For Pathology report gross observation Narrative (Structure of lower outer quadrant of left breast (body structure)) Final 2025-01-16 08:30:00+0100 Pathology report final diagnosis Narrative Final 2025-01-17 Invasives Mammakarzinom NST (ICD-O 8500/3), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). ER+ (85%), PR+ (50%), HER2- (nicht amplifiziert), Ki-67 10%. B-Klassifikation B5b.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: SP
    display:
      v: Surgical Pathology
code:
  coding: https://loinc.org/rdf/60568-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 60568-3
    display:
      v: Pathology Synoptic report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17T15:00:00+01:00
issued:
  v: 2025-01-17T17:00:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
specimen:
  l: CoreNeedleBiopsySpecimenBlock01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenBlock01
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE02
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE02
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE03
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE03
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE04
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE04
specimen:
  l: CoreNeedleBiopsySpecimenSlideER01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideER01
specimen:
  l: CoreNeedleBiopsySpecimenSlideER02
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideER02
specimen:
  l: CoreNeedleBiopsySpecimenSlidePR01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlidePR01
specimen:
  l: CoreNeedleBiopsySpecimenSlidePR02
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlidePR02
specimen:
  l: CoreNeedleBiopsySpecimenSlideHER2-01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHER2-01
specimen:
  l: CoreNeedleBiopsySpecimenSlideHER2-02
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHER2-02
specimen:
  l: CoreNeedleBiopsySpecimenSlideKi67-01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideKi67-01
specimen:
  l: CoreNeedleBiopsySpecimenSlideKi67-02
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideKi67-02
result:
  l: CoreNeedleBiopsyMacroscopicGrouper
  reference:
    v: Observation/CoreNeedleBiopsyMacroscopicGrouper
result:
  l: CoreNeedleBiopsyDiagnosticConclusionGrouper
  reference:
    v: Observation/CoreNeedleBiopsyDiagnosticConclusionGrouper
conclusion:
  v: Invasives Mammakarzinom NST (ICD-O 8500/3), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). ER+ (85%), PR+ (50%), HER2- (nicht amplifiziert), Ki-67 10%. B-Klassifikation B5b.

CoreNeedleBiopsySpecimenPart
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenPart
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
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identifier:
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    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
  system:
    v: https://senologie.example-hospital.de/fhir/specimen/placer
    l: placer
  value:
    v: BX25_105_A
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: FILL
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/122737001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 122737001
    display:
      v: Specimen from breast obtained by core needle biopsy (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
request:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
collection:
  collector:
    l: BreastSurgeonPractitioner
    reference:
      v: Practitioner/BreastSurgeonPractitioner
  collected: DateTime
    v: 2025-01-15T09:30:00+01:00
  method:
    coding: http://snomed.info/id/9911007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 9911007
      display:
        v: Core needle biopsy (procedure)
  body site:
    coding: http://snomed.info/id/33564002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 33564002
      display:
        v: Structure of lower outer quadrant of breast (body structure)
container:
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    coding: http://snomed.info/id/434746001
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434746001
      display:
        v: Specimen vial (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/434162003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434162003
      display:
        v: Neutral buffered formalin (substance)
note:
  text:
    v: HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke.

CoreNeedleBiopsySpecimenBlock01
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenBlock01
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
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identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
collection:
  collected: DateTime
    v: 2025-01-16T08:00:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-01-16T08:00:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

CoreNeedleBiopsySpecimenSlideHE01
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideHE01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlideHE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 1) procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-01-16 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_HE_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
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      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: CoreNeedleBiopsySpecimenBlock01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenBlock01
collection:
  collected: DateTime
    v: 2025-01-16T09:00:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 1)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-01-16T09:15:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlideHE02
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideHE02
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlideHE02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_HE_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 2) procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-01-16 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
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type:
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    system:
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      l: sct
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    display:
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subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
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  reference:
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collection:
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    v: 2025-01-16T09:00:00+01:00
  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 2)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
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        l: sct
      code:
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      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-01-16T09:15:00+01:00
container:
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      system:
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        l: sct
      code:
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      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlideHE03
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideHE03
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlideHE03 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_HE_03 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 3) procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-01-16 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_HE_03
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
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  reference:
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collection:
  collected: DateTime
    v: 2025-01-16T09:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 3)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-01-16T09:15:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlideHE04
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideHE04
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
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      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: CoreNeedleBiopsySpecimenBlock01
  reference:
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collection:
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    v: 2025-01-16T09:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 4)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-01-16T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
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      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlideER01
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideER01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlideER01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_ER_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: ER-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-01-16 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_ER_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: CoreNeedleBiopsySpecimenBlock01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenBlock01
collection:
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    v: 2025-01-16T09:30:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: ER-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: CoreNeedleBiopsySubstanceER
    reference:
      v: Substance/CoreNeedleBiopsySubstanceER
  time: DateTime
    v: 2025-01-16T10:00:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
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      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlideER02
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlideER02
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlideER02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_ER_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: ER-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-01-16 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_ER_02
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
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  reference:
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collection:
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    v: 2025-01-16T09:30:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: ER-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
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        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: CoreNeedleBiopsySubstanceER
    reference:
      v: Substance/CoreNeedleBiopsySubstanceER
  time: DateTime
    v: 2025-01-16T10:00:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
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      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlidePR01
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlidePR01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlidePR01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_PR_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:35:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:35:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: PR-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-01-16 10:05:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_PR_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: CoreNeedleBiopsySpecimenBlock01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenBlock01
collection:
  collected: DateTime
    v: 2025-01-16T09:35:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-01-16T09:35:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: PR-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: CoreNeedleBiopsySubstancePR
    reference:
      v: Substance/CoreNeedleBiopsySubstancePR
  time: DateTime
    v: 2025-01-16T10:05:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

CoreNeedleBiopsySpecimenSlidePR02
type: Specimen
id:
  v: CoreNeedleBiopsySpecimenSlidePR02
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen CoreNeedleBiopsySpecimenSlidePR02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105_A_1_1_PR_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_105 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-01-16 09:35:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-01-16 09:35:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: PR-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-01-16 10:05:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105_A_1_1_PR_02
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_105
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CoreNeedleBiopsySpecimenSlideHER2-01
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text:
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    value: Range
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CoreNeedleBiopsySpecimenSlideHER2-02
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text:
  status:
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CoreNeedleBiopsySpecimenSlideKi67-01
type: Specimen
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text:
  status:
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CoreNeedleBiopsySpecimenSlideKi67-02
type: Specimen
id:
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meta:
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text:
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subject:
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parent:
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    value: Range
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processing:
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CoreNeedleBiopsyMacroscopicGrouper
type: Observation
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper
text:
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code:
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subject:
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effective: DateTime
  v: 2025-01-16T08:30:00+01:00
performer:
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  reference:
    v: Practitioner/PathologistPractitioner
body site:
  coding: http://snomed.info/id/110502005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 110502005
    display:
      v: Structure of lower outer quadrant of left breast (body structure)
has member:
  l: CoreNeedleBiopsyMacroscopicTotalLength
  reference:
    v: Observation/CoreNeedleBiopsyMacroscopicTotalLength
has member:
  l: CoreNeedleBiopsyMacroscopicCylinderCount
  reference:
    v: Observation/CoreNeedleBiopsyMacroscopicCylinderCount
has member:
  l: CoreNeedleBiopsyMacroscopicBlockCount
  reference:
    v: Observation/CoreNeedleBiopsyMacroscopicBlockCount
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMacroscopicTotalLength
type: Observation
id:
  v: CoreNeedleBiopsyMacroscopicTotalLength
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMacroscopicTotalLength Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Gesamtlänge der Stanzzylinder subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-16 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 22 mm (Details: UCUM codemm = 'mm') bodySite: Structure of lower outer quadrant of left breast (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Specimen from breast obtained by core needle biopsy (specimen); note = HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/33728-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33728-7
    display:
      v: Size.maximum dimension in Tumor
  text:
    v: Gesamtlänge der Stanzzylinder
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-16T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 22
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/110502005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 110502005
    display:
      v: Structure of lower outer quadrant of left breast (body structure)
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMacroscopicCylinderCount
type: Observation
id:
  v: CoreNeedleBiopsyMacroscopicCylinderCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMacroscopicCylinderCount Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Anzahl Stanzzylinder subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-16 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 2 count (Details: UCUM code{count} = '{count}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Specimen from breast obtained by core needle biopsy (specimen); note = HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/246205007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 246205007
    display:
      v: Quantity (attribute)
  text:
    v: Anzahl Stanzzylinder
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-16T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 2
  unit:
    v: count
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {count}
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMacroscopicBlockCount
type: Observation
id:
  v: CoreNeedleBiopsyMacroscopicBlockCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMacroscopicBlockCount Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Anzahl Paraffinblöcke subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-16 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 1 count (Details: UCUM code{count} = '{count}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Specimen from breast obtained by core needle biopsy (specimen); note = HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/246205007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 246205007
    display:
      v: Quantity (attribute)
  text:
    v: Anzahl Paraffinblöcke
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-16T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 1
  unit:
    v: count
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {count}
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyDiagnosticConclusionGrouper
type: Observation
id:
  v: CoreNeedleBiopsyDiagnosticConclusionGrouper
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyDiagnosticConclusionGrouper Profile: MII PR Patho Diagnostic Conclusion Grouper version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory code: Pathology report final diagnosis Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann hasMember: Observation Histology and Behavior ICD-O-3 Cancer Observation Histology type in Cancer specimen Narrative Observation Histologic grade [Score] in Breast cancer specimen by Nottingham Observation Nottingham total score of primary malignant neoplasm of breast (observable entity) Observation Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain Observation Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain Observation Progesterone receptor Ag [Presence] in Breast cancer specimen by Immune stain Observation Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain Observation HER2 [Presence] in Breast cancer specimen by Immune stain Observation Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by in situ hybridization Observation HER2 [Interpretation] in Tissue Observation Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain Observation Screening interpretation (observable entity) Observation Presence of microcalcification in excised breast specimen (observable entity) Observation Specimen mammography (procedure) Observation Microcalcification, calcified structure (morphologic abnormality) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
code:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
has member:
  l: CoreNeedleBiopsyHistologicalTypeICDO3
  reference:
    v: Observation/CoreNeedleBiopsyHistologicalTypeICDO3
has member:
  l: CoreNeedleBiopsyMorphologyFreeText
  reference:
    v: Observation/CoreNeedleBiopsyMorphologyFreeText
has member:
  l: CoreNeedleBiopsyNottinghamGrade
  reference:
    v: Observation/CoreNeedleBiopsyNottinghamGrade
has member:
  l: CoreNeedleBiopsyNottinghamSummaryScore
  reference:
    v: Observation/CoreNeedleBiopsyNottinghamSummaryScore
has member:
  l: CoreNeedleBiopsyERStatus
  reference:
    v: Observation/CoreNeedleBiopsyERStatus
has member:
  l: CoreNeedleBiopsyERPercentage
  reference:
    v: Observation/CoreNeedleBiopsyERPercentage
has member:
  l: CoreNeedleBiopsyPRStatus
  reference:
    v: Observation/CoreNeedleBiopsyPRStatus
has member:
  l: CoreNeedleBiopsyPRPercentage
  reference:
    v: Observation/CoreNeedleBiopsyPRPercentage
has member:
  l: CoreNeedleBiopsyHER2IHC
  reference:
    v: Observation/CoreNeedleBiopsyHER2IHC
has member:
  l: CoreNeedleBiopsyHER2ISH
  reference:
    v: Observation/CoreNeedleBiopsyHER2ISH
has member:
  l: CoreNeedleBiopsyHER2Overall
  reference:
    v: Observation/CoreNeedleBiopsyHER2Overall
has member:
  l: CoreNeedleBiopsyKi67
  reference:
    v: Observation/CoreNeedleBiopsyKi67
has member:
  l: CoreNeedleBiopsyInterpretation
  reference:
    v: Observation/CoreNeedleBiopsyInterpretation
has member:
  l: CoreNeedleBiopsyMicrocalcification
  reference:
    v: Observation/CoreNeedleBiopsyMicrocalcification
has member:
  l: CoreNeedleBiopsySpecimenRadiography
  reference:
    v: Observation/CoreNeedleBiopsySpecimenRadiography
has member:
  l: CoreNeedleBiopsyMicrocalcificationCorrelation
  reference:
    v: Observation/CoreNeedleBiopsyMicrocalcificationCorrelation
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyHistologicalTypeICDO3
type: Observation
id:
  v: CoreNeedleBiopsyHistologicalTypeICDO3
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyHistologicalTypeICDO3 Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histology and Behavior ICD-O-3 Cancer subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Invasives duktales Karzinom (NST) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/59847-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 59847-4
    display:
      v: Histology and Behavior ICD-O-3 Cancer
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/82711006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 82711006
    display:
      v: Infiltrating duct carcinoma (morphologic abnormality)
  text:
    v: Invasives duktales Karzinom (NST)
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMorphologyFreeText
type: Observation
id:
  v: CoreNeedleBiopsyMorphologyFreeText
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMorphologyFreeText Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histology type in Cancer specimen Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Invasives Karzinom, NST specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/33731-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33731-1
    display:
      v: Histology type in Cancer specimen Narrative
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: Invasives Karzinom, NST
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyNottinghamGrade
type: Observation
id:
  v: CoreNeedleBiopsyNottinghamGrade
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyNottinghamGrade Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histologischer Tumorgrad (Elston-Ellis-Grad) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Nottingham Grad 2 (Score 6) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Observation Nottingham total score of primary malignant neoplasm of breast (observable entity)
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44648-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44648-4
    display:
      v: Histologic grade [Score] in Breast cancer specimen by Nottingham
  text:
    v: Histologischer Tumorgrad (Elston-Ellis-Grad)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/1155703007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1155703007
    display:
      v: G2: Moderately differentiated histologic grade (qualifier value)
  text:
    v: Nottingham Grad 2 (Score 6)
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
derived from:
  l: CoreNeedleBiopsyNottinghamSummaryScore
  reference:
    v: Observation/CoreNeedleBiopsyNottinghamSummaryScore

CoreNeedleBiopsyNottinghamSummaryScore
type: Observation
id:
  v: CoreNeedleBiopsyNottinghamSummaryScore
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyNottinghamSummaryScore Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Elston-Ellis-Summenscore subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: 6 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' component code: Glandular differentiation [Score] in Breast cancer specimen by Nottingham value: 3 score (Details: UCUM code{score} = '{score}') component code: Nuclear pleomorphism in Breast tumor by Nottingham value: 2 score (Details: UCUM code{score} = '{score}') component code: Mitotic rate [Score] in Breast cancer specimen by Nottingham value: 1 score (Details: UCUM code{score} = '{score}')
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1287461000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1287461000
    display:
      v: Nottingham total score of primary malignant neoplasm of breast (observable entity)
  text:
    v: Elston-Ellis-Summenscore
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 6
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/85321-8
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 85321-8
      display:
        v: Glandular differentiation [Score] in Breast cancer specimen by Nottingham
  value: Quantity
    value:
      v: 3
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}
component:
  code:
    coding: https://loinc.org/rdf/44645-0
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 44645-0
      display:
        v: Nuclear pleomorphism in Breast tumor by Nottingham
  value: Quantity
    value:
      v: 2
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}
component:
  code:
    coding: https://loinc.org/rdf/85300-2
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 85300-2
      display:
        v: Mitotic rate [Score] in Breast cancer specimen by Nottingham
  value: Quantity
    value:
      v: 1
    unit:
      v: score
    system:
      v: http://unitsofmeasure.org
      l: unitsofmeasure.org
    code:
      v: {score}

CoreNeedleBiopsyERStatus
type: Observation
id:
  v: CoreNeedleBiopsyERStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyERStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: ER positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85337-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85337-4
    display:
      v: Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA6576-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA6576-8
    display:
      v: Positive
  text:
    v: ER positiv
specimen:
  l: CoreNeedleBiopsySpecimenSlideER01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideER01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

CoreNeedleBiopsyERPercentage
type: Observation
id:
  v: CoreNeedleBiopsyERPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyERPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: 85 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85329-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85329-1
    display:
      v: Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 85
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: CoreNeedleBiopsySpecimenSlideER01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideER01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

CoreNeedleBiopsyPRStatus
type: Observation
id:
  v: CoreNeedleBiopsyPRStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyPRStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Progesterone receptor Ag [Presence] in Breast cancer specimen by Immune stain subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: PR positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85339-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85339-0
    display:
      v: Progesterone receptor Ag [Presence] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA6576-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA6576-8
    display:
      v: Positive
  text:
    v: PR positiv
specimen:
  l: CoreNeedleBiopsySpecimenSlidePR01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlidePR01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

CoreNeedleBiopsyPRPercentage
type: Observation
id:
  v: CoreNeedleBiopsyPRPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyPRPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: 50 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85325-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85325-9
    display:
      v: Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 50
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: CoreNeedleBiopsySpecimenSlidePR01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlidePR01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

CoreNeedleBiopsyHER2ISH
type: Observation
id:
  v: CoreNeedleBiopsyHER2ISH
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyHER2ISH Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by in situ hybridization subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: HER2 negativ (nicht amplifiziert) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HER2_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ERBB2
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1363314005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1363314005
    display:
      v: Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by in situ hybridization
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: HER2 negativ (nicht amplifiziert)
specimen:
  l: CoreNeedleBiopsySpecimenSlideHER2-01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHER2-01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3430
      display:
        v: ERBB2

CoreNeedleBiopsyKi67
type: Observation
id:
  v: CoreNeedleBiopsyKi67
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyKi67 Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: 10 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_Ki67_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] MKI67
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85330-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85330-9
    display:
      v: Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 10
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: CoreNeedleBiopsySpecimenSlideKi67-01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideKi67-01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:7107
      display:
        v: MKI67

CoreNeedleBiopsyInterpretation
type: Observation
id:
  v: CoreNeedleBiopsyInterpretation
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyInterpretation Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: B-Klassifikation subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: B5b specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/271937008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 271937008
    display:
      v: Screening interpretation (observable entity)
  text:
    v: B-Klassifikation
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/10179008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 10179008
    display:
      v: Invasive (qualifier value)
  text:
    v: B5b
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMicrocalcification
type: Observation
id:
  v: CoreNeedleBiopsyMicrocalcification
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMicrocalcification Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Presence of microcalcification in excised breast specimen (observable entity) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Keine relevanten Mikroverkalkungen specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1240404008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240404008
    display:
      v: Presence of microcalcification in excised breast specimen (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Keine relevanten Mikroverkalkungen
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsySpecimenRadiography
type: Observation
id:
  v: CoreNeedleBiopsySpecimenRadiography
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsySpecimenRadiography Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Präparateradiogramm subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Präparateradiogramm gesehen specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Specimen from breast obtained by core needle biopsy (specimen); note = HG-Stanzen/Mamma, li., 5 Uhr, 5 cm von Mamille, US-gestützte Stanzbiopsie. 2 Stanzzylinder, zusammen 22 mm, mittelfest, grauweißlich, Bleistiftminenstärke. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/80865008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 80865008
    display:
      v: Specimen mammography (procedure)
  text:
    v: Präparateradiogramm
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: Präparateradiogramm gesehen
specimen:
  l: CoreNeedleBiopsySpecimenPart
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenPart
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

CoreNeedleBiopsyMicrocalcificationCorrelation
type: Observation
id:
  v: CoreNeedleBiopsyMicrocalcificationCorrelation
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation CoreNeedleBiopsyMicrocalcificationCorrelation Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Breast Pathology biopsy report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Korrelation Mikroverkalkung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-01-17 performer: Practitioner Elisabeth Hoffmann value: Vorliegende Verkalkung radiologisch nicht relevant (kleiner als 100 Mikrometer) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_105; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: CoreNeedleBiopsyReportRequest
  reference:
    v: ServiceRequest/CoreNeedleBiopsyReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/12747003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 12747003
    display:
      v: Microcalcification, calcified structure (morphologic abnormality)
  text:
    v: Korrelation Mikroverkalkung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-17
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: Vorliegende Verkalkung radiologisch nicht relevant (kleiner als 100 Mikrometer)
specimen:
  l: CoreNeedleBiopsySpecimenSlideHE01
  reference:
    v: Specimen/CoreNeedleBiopsySpecimenSlideHE01
derived from:
  l: QuestionnaireResponseCoreNeedleBiopsy
  reference:
    v: QuestionnaireResponse/QuestionnaireResponseCoreNeedleBiopsy

QuestionnaireResponseCoreNeedleBiopsy
type: QuestionnaireResponse
id:
  v: QuestionnaireResponseCoreNeedleBiopsy
text:
  status:
    v: generated
  div:
    v: Generated Narrative: QuestionnaireResponse QuestionnaireResponseCoreNeedleBiopsy LinkID Text Definition Answer<img src="[binary]" alt="doco" style="background-color: inherit"/> QuestionnaireResponseCoreNeedleBiopsy Questionnaire:http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy #xD; cnb.root Stanzbiopsie Mamma #xD; cnb.patient Patientendaten #xD; cnb.patient.name Familienname Becker #xD; cnb.patient.given Vorname Sabine #xD; cnb.patient.dob Geburtsdatum 1971-03-15 #xD; cnb.patient.id Patienten-Identifikator PAT-2025-105 #xD; cnb.clinical Klinische Angaben #xD; cnb.clinical.indication Untersuchungsanlass Herdbefund/Architekturstörung linke Brust #xD; cnb.clinical.birads BI-RADS 4b #xD; cnb.clinical.imaging Bildgebungsmodalität Ultraschall #xD; cnb.specimen Untersuchungsmaterial #xD; cnb.specimen.type Materialart HG-Stanzen/Mamma #xD; cnb.specimen.side Seitenlokalisation SNOMED CT: 7771000 (Left (qualifier value)) #xD; cnb.specimen.clock Uhrzeigerlokalisation 5 Uhr #xD; cnb.specimen.distance Abstand von Mamille 5 cm (Details: UCUM codecm = 'cm') #xD; cnb.specimen.length Gesamtlänge der Stanzzylinder 22 mm (Details: UCUM codemm = 'mm') #xD; cnb.specimen.cylinders Anzahl Stanzzylinder 2 #xD; cnb.specimen.blocks Anzahl Blöcke 1 #xD; cnb.histology Histologischer Tumortyp #xD; cnb.histology.icdo3 Histologischer Typ ICD-O-3 unknown: 8500/3 (Invasives duktales Karzinom (NST)) #xD; cnb.grading Nottingham-Grading #xD; cnb.grading.grade Nottingham-Grad G2 #xD; cnb.grading.score Elston-Ellis Summenscore 6 #xD; cnb.grading.tubules Tubulusbildung 3 #xD; cnb.grading.pleomorphism Kernpleomorphie 2 #xD; cnb.grading.mitoses Mitoserate 1 #xD; cnb.biomarkers Biomarker #xD; cnb.biomarkers.er Östrogenrezeptor SNOMED CT: 52101004 (Present (qualifier value)) #xD; cnb.biomarkers.er.pct ER Prozent 85 #xD; cnb.biomarkers.pr Progesteronrezeptor SNOMED CT: 52101004 (Present (qualifier value)) #xD; cnb.biomarkers.pr.pct PR Prozent 50 #xD; cnb.biomarkers.her2 HER2 Amplifikation Negativ …
questionnaire:
  v: http://breastcancerspec.org/Questionnaire/Core-Needle-Biopsy
  l: Core-Needle-Biopsy
status:
  v: completed
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
authored:
  v: 2025-01-17T14:30:00+01:00
author:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
item:
  link id:
    v: cnb.root
  text:
    v: Stanzbiopsie Mamma
  item:
    link id:
      v: cnb.patient
    text:
      v: Patientendaten
    item:
      link id:
        v: cnb.patient.name
      text:
        v: Familienname
      answer:
        value: String
    item:
      link id:
        v: cnb.patient.given
      text:
        v: Vorname
      answer:
        value: String
    item:
      link id:
        v: cnb.patient.dob
      text:
        v: Geburtsdatum
      answer:
        value: Date
    item:
      link id:
        v: cnb.patient.id
      text:
        v: Patienten-Identifikator
      answer:
        value: String
  item:
    link id:
      v: cnb.clinical
    text:
      v: Klinische Angaben
    item:
      link id:
        v: cnb.clinical.indication
      text:
        v: Untersuchungsanlass
      answer:
        value: String
    item:
      link id:
        v: cnb.clinical.birads
      text:
        v: BI-RADS
      answer:
        value: String
    item:
      link id:
        v: cnb.clinical.imaging
      text:
        v: Bildgebungsmodalität
      answer:
        value: String
  item:
    link id:
      v: cnb.specimen
    text:
      v: Untersuchungsmaterial
    item:
      link id:
        v: cnb.specimen.type
      text:
        v: Materialart
      answer:
        value: String
    item:
      link id:
        v: cnb.specimen.side
      text:
        v: Seitenlokalisation
      answer:
        value: Coding
    item:
      link id:
        v: cnb.specimen.clock
      text:
        v: Uhrzeigerlokalisation
      answer:
        value: String
    item:
      link id:
        v: cnb.specimen.distance
      text:
        v: Abstand von Mamille
      answer:
        value: Quantity
    item:
      link id:
        v: cnb.specimen.length
      text:
        v: Gesamtlänge der Stanzzylinder
      answer:
        value: Quantity
    item:
      link id:
        v: cnb.specimen.cylinders
      text:
        v: Anzahl Stanzzylinder
      answer:
        value: Integer
    item:
      link id:
        v: cnb.specimen.blocks
      text:
        v: Anzahl Blöcke
      answer:
        value: Integer
  item:
    link id:
      v: cnb.histology
    text:
      v: Histologischer Tumortyp
    item:
      link id:
        v: cnb.histology.icdo3
      text:
        v: Histologischer Typ ICD-O-3
      answer:
        value: Coding
  item:
    link id:
      v: cnb.grading
    text:
      v: Nottingham-Grading
    item:
      link id:
        v: cnb.grading.grade
      text:
        v: Nottingham-Grad
      answer:
        value: String
    item:
      link id:
        v: cnb.grading.score
      text:
        v: Elston-Ellis Summenscore
      answer:
        value: Integer
    item:
      link id:
        v: cnb.grading.tubules
      text:
        v: Tubulusbildung
      answer:
        value: Integer
    item:
      link id:
        v: cnb.grading.pleomorphism
      text:
        v: Kernpleomorphie
      answer:
        value: Integer
    item:
      link id:
        v: cnb.grading.mitoses
      text:
        v: Mitoserate
      answer:
        value: Integer
  item:
    link id:
      v: cnb.biomarkers
    text:
      v: Biomarker
    item:
      link id:
        v: cnb.biomarkers.er
      text:
        v: Östrogenrezeptor

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

String
v: Becker

String
v: Sabine

Date
v: 1971-03-15

String
v: PAT-2025-105

String
v: Herdbefund/Architekturstörung linke Brust

String
v: 4b

String
v: Ultraschall

String
v: HG-Stanzen/Mamma

Coding
type: http://snomed.info/id/7771000
system:
  v: http://snomed.info/sct
  l: sct
code:
  v: 7771000
display:
  v: Left (qualifier value)

String
v: 5 Uhr

Quantity
value:
  v: 5
unit:
  v: cm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: cm

Quantity
value:
  v: 22
unit:
  v: mm
system:
  v: http://unitsofmeasure.org
  l: unitsofmeasure.org
code:
  v: mm

Integer
v: 2

Integer
v: 1

Coding
system:
  v: urn:oid:2.16.840.1.113883.6.43.1
  l: 2.16.840.1.113883.6.43.1
code:
  v: 8500/3
display:
  v: Invasives duktales Karzinom (NST)

String
v: G2

Integer
v: 6

Integer
v: 3

Integer
v: 2

Integer
v: 1

value: Coding
  type: http://snomed.info/id/52101004
  system:
    v: http://snomed.info/sct
    l: sct
  code:
    v: 52101004
  display:
    v: Present (qualifier value)

link id:
  v: cnb.biomarkers.er.pct
text:
  v: ER Prozent
answer:
  value: Integer
    v: 85

link id:
  v: cnb.biomarkers.pr
text:
  v: Progesteronrezeptor
answer:
  value: Coding
    type: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)

link id:
  v: cnb.biomarkers.pr.pct
text:
  v: PR Prozent
answer:
  value: Integer
    v: 50

link id:
  v: cnb.biomarkers.her2
text:
  v: HER2 Amplifikation
answer:
  value: String
    v: Negativ (nicht amplifiziert)

link id:
  v: cnb.biomarkers.ki67
text:
  v: Ki-67
answer:
  value: Integer
    v: 10

link id:
  v: cnb.bclassification
text:
  v: B-Klassifikation
item:
  link id:
    v: cnb.bclassification.value
  text:
    v: B-Klassifikation (NHSBSP)
  answer:
    value: String
      v: B5b

link id:
  v: cnb.microcalcification
text:
  v: Mikroverkalkungen
item:
  link id:
    v: cnb.microcalcification.relevant
  text:
    v: Relevante Mikroverkalkungen
  answer:
    value: Coding
      type: http://snomed.info/id/2667000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 2667000
      display:
        v: Absent (qualifier value)
item:
  link id:
    v: cnb.microcalcification.radiography
  text:
    v: Präparateradiogramm
  answer:
    value: String
      v: Gesehen
item:
  link id:
    v: cnb.microcalcification.correlation
  text:
    v: Korrelation Mikroverkalkung
  answer:
    value: String
      v: Vorliegende Verkalkung radiologisch nicht relevant (kleiner als 100 Mikrometer)