IntegratedDocument
type: Bundle
node role: treeRoot
id:
  v: IntegratedDocument
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_004
type:
  v: document
timestamp:
  v: 2025-02-10T17:00:00+01:00
entry:
  full url:
    v: http://breastcancerspec.org/Composition/IntegratedComposition
    l: IntegratedComposition
  resource: IntegratedComposition
entry:
  full url:
    v: http://breastcancerspec.org/Patient/Patient4
    l: Patient4
  resource: Patient4
entry:
  full url:
    v: http://breastcancerspec.org/Organization/PathologyLabOrganization
    l: PathologyLabOrganization
  resource: PathologyLabOrganization
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/PathologistPractitioner
    l: PathologistPractitioner
  resource: PathologistPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Practitioner/BreastSurgeonPractitioner
    l: BreastSurgeonPractitioner
  resource: BreastSurgeonPractitioner
entry:
  full url:
    v: http://breastcancerspec.org/Encounter/IntegratedEncounter
    l: IntegratedEncounter
  resource: IntegratedEncounter
entry:
  full url:
    v: http://breastcancerspec.org/Condition/IntegratedDiagnosisConfirmed
    l: IntegratedDiagnosisConfirmed
  resource: IntegratedDiagnosisConfirmed
entry:
  full url:
    v: http://breastcancerspec.org/ServiceRequest/IntegratedReportRequest
    l: IntegratedReportRequest
  resource: IntegratedReportRequest
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/IntegratedImagingReport
    l: IntegratedImagingReport
  resource: IntegratedImagingReport
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedCancerHistory
    l: IntegratedCancerHistory
  resource: IntegratedCancerHistory
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedPriorTherapy
    l: IntegratedPriorTherapy
  resource: IntegratedPriorTherapy
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedRadiologicalExtent
    l: IntegratedRadiologicalExtent
  resource: IntegratedRadiologicalExtent
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedSpecimenMarking
    l: IntegratedSpecimenMarking
  resource: IntegratedSpecimenMarking
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedSpecimenRadiographyClinical
    l: IntegratedSpecimenRadiographyClinical
  resource: IntegratedSpecimenRadiographyClinical
entry:
  full url:
    v: http://breastcancerspec.org/Observation/IntegratedGeneticPredisposition
    l: IntegratedGeneticPredisposition
  resource: IntegratedGeneticPredisposition
entry:
  full url:
    v: http://breastcancerspec.org/DiagnosticReport/IntegratedReport
    l: IntegratedReport
  resource: IntegratedReport
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenPart
    l: IntegratedBETSpecimenPart
  resource: IntegratedBETSpecimenPart
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock01
    l: IntegratedBETSpecimenBlock01
  resource: IntegratedBETSpecimenBlock01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock02
    l: IntegratedBETSpecimenBlock02
  resource: IntegratedBETSpecimenBlock02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock03
    l: IntegratedBETSpecimenBlock03
  resource: IntegratedBETSpecimenBlock03
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock04
    l: IntegratedBETSpecimenBlock04
  resource: IntegratedBETSpecimenBlock04
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock05
    l: IntegratedBETSpecimenBlock05
  resource: IntegratedBETSpecimenBlock05
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock06
    l: IntegratedBETSpecimenBlock06
  resource: IntegratedBETSpecimenBlock06
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideHE01
    l: IntegratedBETSlideHE01
  resource: IntegratedBETSlideHE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideHE02
    l: IntegratedBETSlideHE02
  resource: IntegratedBETSlideHE02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideER01
    l: IntegratedBETSlideER01
  resource: IntegratedBETSlideER01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlidePR01
    l: IntegratedBETSlidePR01
  resource: IntegratedBETSlidePR01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideHER2IHC01
    l: IntegratedBETSlideHER2IHC01
  resource: IntegratedBETSlideHER2IHC01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideKi67-01
    l: IntegratedBETSlideKi67-01
  resource: IntegratedBETSlideKi67-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideCK18-01
    l: IntegratedBETSlideCK18-01
  resource: IntegratedBETSlideCK18-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlidep40-01
    l: IntegratedBETSlidep40-01
  resource: IntegratedBETSlidep40-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideECad-01
    l: IntegratedBETSlideECad-01
  resource: IntegratedBETSlideECad-01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideBlock02-HE01
    l: IntegratedBETSlideBlock02-HE01
  resource: IntegratedBETSlideBlock02-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideBlock02-HE02
    l: IntegratedBETSlideBlock02-HE02
  resource: IntegratedBETSlideBlock02-HE02
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Superior-HE01
    l: IntegratedBETSlideRR-Superior-HE01
  resource: IntegratedBETSlideRR-Superior-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Inferior-HE01
    l: IntegratedBETSlideRR-Inferior-HE01
  resource: IntegratedBETSlideRR-Inferior-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Medial-HE01
    l: IntegratedBETSlideRR-Medial-HE01
  resource: IntegratedBETSlideRR-Medial-HE01
entry:
  full url:
    v: http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Lateral-HE01
    l: IntegratedBETSlideRR-Lateral-HE01
  resource: IntegratedBETSlideRR-Lateral-HE01

IntegratedComposition
type: Composition
id:
  v: IntegratedComposition
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Composition IntegratedComposition identifier: Accession ID/PATH-COMP-2025-300 status: Final type: Pathology report (record artifact) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_300; status = finished; class = IMP (IMP) date: 2025-02-10 17:00:00+0100 author: Institut für Pathologie title: Histopathologischer Befundbericht — BET Mamma links mit SLN-Biopsie Axilla Attesters - Mode Party * Legal Organization Institut für Pathologie custodian: Organization Institut für Pathologie Events - Code Detail * pathology report entry task ServiceRequest Pathology synoptic report
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: http://example.hospital.de/pathology-reports
    l: pathology-reports
  value:
    v: PATH-COMP-2025-300
status:
  v: final
type:
  coding:
    system:
      v: http://ihe-d.de/CodeSystems/IHEXDStypeCode
      l: IHEXDStypeCode
    code:
      v: PATH
  coding: http://snomed.info/id/371528001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371528001
    display:
      v: Pathology report (record artifact)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
  display:
    v: Sabine Becker, geb. 15.03.1971 (PAT-2025-105)
encounter:
  l: IntegratedEncounter
  reference:
    v: Encounter/IntegratedEncounter
date:
  v: 2025-02-10T17:00:00+01:00
author:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
  display:
    v: Institut für Pathologie
title:
  v: Histopathologischer Befundbericht — BET Mamma links mit SLN-Biopsie Axilla
attester:
  mode:
    v: legal
  party:
    l: PathologyLabOrganization
    reference:
      v: Organization/PathologyLabOrganization
custodian:
  l: PathologyLabOrganization
  reference:
    v: Organization/PathologyLabOrganization
event:
  code:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v3-ActCode
        l: v3-ActCode
      code:
        v: PATREPE
  detail:
    l: IntegratedReportRequest
    reference:
      v: ServiceRequest/IntegratedReportRequest
section:
  title:
    v: Pathologiebefundbericht
  code:
    coding: https://loinc.org/rdf/11526-1
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 11526-1
      display:
        v: Pathology study
  text:
    status:
      v: additional
    div:
      v: Klinische Angaben Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links mit SLN-Biopsie Axilla indiziert. Drahthäkchenmarkierung. Keine neoadjuvante Therapie. Ersterkrankung. Keine bekannte genetische Prädisposition. Präparateradiographie beigelegt. Axilla klinisch unauffällig (cN0). Material A) BET-Exzisionspräparat: Mamma links, mit Haut, Drahthäkchen in situ B) SLN-Exzisat: Sentinel-Lymphknoten-Exzisat linke Axilla, 2 SLN identifiziert (Patentblau-markiert) Makroskopie Mamma Größe 42 × 35 × 18 mm Gewicht 10 g Quadrant Unterer äußerer Quadrant Zifferblatt 5 Uhr Abstand Mamille 50 mm Lamellierung 8 Scheiben à 5 mm Schnittfläche Grau-weißlich, derber Herdbefund zentral in Scheibe III–V, ca. 18 mm Paraffinblöcke 6 Makroskopie Axilla SLN #1 12 × 8 × 6 mm, Patentblau-markiert, halbiert SLN #2 10 × 7 × 5 mm, Patentblau-markiert, halbiert Einbettung Beide SLN vollständig eingebettet, je 1 Paraffinblock Schnellschnitt SLN #1: Tumorfrei im Schnellschnitt. SLN #2: Tumorfrei im Schnellschnitt. → Keine Axilladissektion. Hinweis: Mikrometastase in SLN #1 erst in den Paraffinschnittstufen nachgewiesen. Mikroskopie Mamma Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion. Mikroskopie Axilla SLN #1: Im Randsinus Nachweis einer Mikrometastase, maximal 1,2 mm messend. Keine Kapseldurchbrechung. SLN #2: In allen Schnittstufen tumorfrei. Kein Anhalt für isolierte Tumorzellen (ITC). Diagnostische Schlus…
  entry:
    l: IntegratedReport
    reference:
      v: DiagnosticReport/IntegratedReport

Patient4
type: Patient
id:
  v: Patient4
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Patient Patient4 Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/patient-ids
    l: patient-ids
  value:
    v: PAT-2025-105
name:
  family:
    v: Becker
  given:
    v: Sabine
gender:
  v: female
birth date:
  v: 1971-03-15

PathologyLabOrganization
type: Organization
id:
  v: PathologyLabOrganization
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Organization PathologyLabOrganization identifier: http://example.hospital.de/organization-ids/ORG-PATH-001 name: Institut für Pathologie
identifier:
  system:
    v: http://example.hospital.de/organization-ids
    l: organization-ids
  value:
    v: ORG-PATH-001
name:
  v: Institut für Pathologie

PathologistPractitioner
type: Practitioner
id:
  v: PathologistPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner PathologistPractitioner identifier: http://example.hospital.de/practitioner-ids/PATH-001 name: Elisabeth Hoffmann Qualifications - Code * Pathology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: PATH-001
name:
  family:
    v: Hoffmann
  given:
    v: Elisabeth
  prefix:
    v: Dr.
qualification:
  code:
    coding: http://snomed.info/id/394595002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394595002
      display:
        v: Pathology

BreastSurgeonPractitioner
type: Practitioner
id:
  v: BreastSurgeonPractitioner
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Practitioner BreastSurgeonPractitioner identifier: http://example.hospital.de/practitioner-ids/GYN-001 name: Thomas Richter Qualifications - Code * Gynecology
identifier:
  system:
    v: http://example.hospital.de/practitioner-ids
    l: practitioner-ids
  value:
    v: GYN-001
name:
  family:
    v: Richter
  given:
    v: Thomas
  prefix:
    v: Prof. Dr.
qualification:
  code:
    coding: http://snomed.info/id/394586005
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 394586005
      display:
        v: Gynecology

IntegratedEncounter
type: Encounter
id:
  v: IntegratedEncounter
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Encounter IntegratedEncounter identifier: http://example.hospital.de/encounters/E_25_300 status: Finished class: [not stated]: IMP (IMP) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
identifier:
  system:
    v: http://example.hospital.de/encounters
    l: encounters
  value:
    v: E_25_300
status:
  v: finished
class:
  code:
    v: IMP
subject:
  l: Patient4
  reference:
    v: Patient/Patient4

IntegratedDiagnosisConfirmed
type: Condition
id:
  v: IntegratedDiagnosisConfirmed
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/core/modul-diagnose/StructureDefinition/Diagnose
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Condition IntegratedDiagnosisConfirmed Profile: MII PR Diagnose Condition version: 2026.0.0 clinicalStatus: Active verificationStatus: Confirmed category: Encounter Diagnosis code: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_300; status = finished; class = IMP (IMP) onset: 2025-01-15 recordedDate: 2025-02-05 note: Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links mit SLN-Biopsie Axilla indiziert.
clinical status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-clinical
      l: condition-clinical
    code:
      v: active
verification status:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-ver-status
      l: condition-ver-status
    code:
      v: confirmed
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/condition-category
      l: condition-category
    code:
      v: encounter-diagnosis
code:
  coding:
    system:
      v: http://fhir.de/CodeSystem/bfarm/icd-10-gm
      l: icd-10-gm
    version:
      v: 2025
    code:
      v: C50.5
    display:
      v: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: IntegratedEncounter
  reference:
    v: Encounter/IntegratedEncounter
onset: DateTime
  v: 2025-01-15
recorded date:
  v: 2025-02-05
note:
  text:
    v: Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links mit SLN-Biopsie Axilla indiziert.

IntegratedReportRequest
type: ServiceRequest
id:
  v: IntegratedReportRequest
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request
text:
  status:
    v: generated
  div:
    v: Generated Narrative: ServiceRequest IntegratedReportRequest Profile: MII PR Patho Service Request version: 2026.0.0 identifier: Placer Identifier/PATH-RPT-2025-300 status: Completed intent: Order category: Pathology consultation, comprehensive, records and specimen with report (procedure) code: Pathology synoptic report subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_300; status = finished; class = IMP (IMP) requester: Practitioner Thomas Richter performer: Practitioner Elisabeth Hoffmann reasonCode: Malignant neoplasm of breast (disorder) supportingInfo: Condition Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse Diagnostic Report for 'MG Breast Screening' for '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Observation Personal history of primary malignant neoplasm of breast (situation) Observation Cancer treatment --preoperative Observation Lesion size, largest dimension (observable entity) Observation Insertion of marker into breast using X-ray guidance (procedure) Observation 80865008|Specimen mammography|:363702006|Has focus|=185008008|Medical reports sent| Observation Diathesis, function (observable entity) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = a…
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
      display:
        v: Placer Identifier
  system:
    v: http://example.hospital.de/serviceRequest
    l: serviceRequest
  value:
    v: PATH-RPT-2025-300
status:
  v: completed
intent:
  v: order
category:
  coding: http://snomed.info/id/726007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 726007
    display:
      v: Pathology consultation, comprehensive, records and specimen with report (procedure)
code:
  coding: https://loinc.org/rdf/60568-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 60568-3
    display:
      v: Pathology synoptic report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
encounter:
  l: IntegratedEncounter
  reference:
    v: Encounter/IntegratedEncounter
requester:
  l: BreastSurgeonPractitioner
  reference:
    v: Practitioner/BreastSurgeonPractitioner
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
reason code:
  coding: http://snomed.info/id/254837009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 254837009
    display:
      v: Malignant neoplasm of breast (disorder)
supporting info:
  l: IntegratedDiagnosisConfirmed
  reference:
    v: Condition/IntegratedDiagnosisConfirmed
supporting info:
  l: IntegratedImagingReport
  reference:
    v: DiagnosticReport/IntegratedImagingReport
supporting info:
  l: IntegratedCancerHistory
  reference:
    v: Observation/IntegratedCancerHistory
supporting info:
  l: IntegratedPriorTherapy
  reference:
    v: Observation/IntegratedPriorTherapy
supporting info:
  l: IntegratedRadiologicalExtent
  reference:
    v: Observation/IntegratedRadiologicalExtent
supporting info:
  l: IntegratedSpecimenMarking
  reference:
    v: Observation/IntegratedSpecimenMarking
supporting info:
  l: IntegratedSpecimenRadiographyClinical
  reference:
    v: Observation/IntegratedSpecimenRadiographyClinical
supporting info:
  l: IntegratedGeneticPredisposition
  reference:
    v: Observation/IntegratedGeneticPredisposition
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
specimen:
  l: IntegratedSLNSpecimenPart
  reference:
    v: Specimen/IntegratedSLNSpecimenPart

IntegratedImagingReport
type: DiagnosticReport
id:
  v: IntegratedImagingReport
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport IntegratedImagingReport MG Breast Screening (Radiology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-01-08 Report Details BI-RADS 4b: Herdbefund linke Brust, unterer äußerer Quadrant, 5 Uhr, 5 cm von Mamille. Radiologische Ausdehnung ca. 15 mm. Mammografie und Ultraschall. Klinisch unauffällige Axilla (cN0). Indikation zur BET mit SLN-Biopsie.
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: RAD
    display:
      v: Radiology
code:
  coding: https://loinc.org/rdf/24606-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 24606-6
    display:
      v: MG Breast Screening
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-01-08
conclusion:
  v: BI-RADS 4b: Herdbefund linke Brust, unterer äußerer Quadrant, 5 Uhr, 5 cm von Mamille. Radiologische Ausdehnung ca. 15 mm. Mammografie und Ultraschall. Klinisch unauffällige Axilla (cN0). Indikation zur BET mit SLN-Biopsie.

IntegratedCancerHistory
type: Observation
id:
  v: IntegratedCancerHistory
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedCancerHistory status: Final code: Brustkrebsvorgeschichte subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Ersterkrankung
status:
  v: final
code:
  coding: http://snomed.info/id/415076002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 415076002
    display:
      v: Personal history of primary malignant neoplasm of breast (situation)
  text:
    v: Brustkrebsvorgeschichte
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  text:
    v: Ersterkrankung

IntegratedPriorTherapy
type: Observation
id:
  v: IntegratedPriorTherapy
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedPriorTherapy status: Final code: Vorchirurgische Therapie bei invasivem Karzinom subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Keine neoadjuvante Therapie
status:
  v: final
code:
  coding: https://loinc.org/rdf/81167-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 81167-9
    display:
      v: Cancer treatment --preoperative
  text:
    v: Vorchirurgische Therapie bei invasivem Karzinom
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/373067005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 373067005
    display:
      v: No (qualifier value)
  text:
    v: Keine neoadjuvante Therapie

IntegratedRadiologicalExtent
type: Observation
id:
  v: IntegratedRadiologicalExtent
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedRadiologicalExtent status: Final code: Radiologische Ausdehnung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: 15 mm (Details: UCUM codemm = 'mm')
status:
  v: final
code:
  coding: http://snomed.info/id/396361002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 396361002
    display:
      v: Lesion size, largest dimension (observable entity)
  text:
    v: Radiologische Ausdehnung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: Quantity
  value:
    v: 15
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm

IntegratedSpecimenMarking
type: Observation
id:
  v: IntegratedSpecimenMarking
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedSpecimenMarking status: Final code: Befundmarkierung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Drahthäkchen
status:
  v: final
code:
  coding: http://snomed.info/id/836381000000102
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 836381000000102
    display:
      v: Insertion of marker into breast using X-ray guidance (procedure)
  text:
    v: Befundmarkierung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  text:
    v: Drahthäkchen

IntegratedSpecimenRadiographyClinical
type: Observation
id:
  v: IntegratedSpecimenRadiographyClinical
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedSpecimenRadiographyClinical status: Final code: Präparateradiographie beigelegt subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Ja, beigelegt
status:
  v: final
code:
  coding:
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 80865008:363702006=185008008
    display:
      v: 80865008|Specimen mammography|:363702006|Has focus|=185008008|Medical reports sent|
  text:
    v: Präparateradiographie beigelegt
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: Ja, beigelegt

IntegratedGeneticPredisposition
type: Observation
id:
  v: IntegratedGeneticPredisposition
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedGeneticPredisposition status: Final code: Genetische Prädisposition subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) value: Nicht bekannt
status:
  v: final
code:
  coding: http://snomed.info/id/76522002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76522002
    display:
      v: Diathesis, function (observable entity)
  text:
    v: Genetische Prädisposition
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
value: CodeableConcept
  coding: http://snomed.info/id/261665006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 261665006
    display:
      v: Unknown (qualifier value)
  text:
    v: Nicht bekannt

IntegratedReport
type: DiagnosticReport
id:
  v: IntegratedReport
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report
text:
  status:
    v: generated
  div:
    v: Generated Narrative: DiagnosticReport IntegratedReport Profile: MII PR Patho Report version: 2026.0.0 Pathology Synoptic report (Surgical Pathology) Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) When For 2025-02-10 14:00:00+0100 Reported 2025-02-10 17:00:00+0100 Performer Practitioner Elisabeth Hoffmann Identifier Accession ID/E_25_300 Report Details Code Value Flags When For Pathology report gross observation Narrative Final 2025-02-06 08:30:00+0100 Pathology report final diagnosis Narrative Final 2025-02-10 Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c pN1mi(sn), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%. SLN 1/2 befallen (Mikrometastase 1,2 mm in SLN #1), keine extranodale Infiltration.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: ACSN
      display:
        v: Accession ID
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/v2-0074
      l: v2-0074
    code:
      v: SP
    display:
      v: Surgical Pathology
code:
  coding: https://loinc.org/rdf/60568-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 60568-3
    display:
      v: Pathology Synoptic report
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10T14:00:00+01:00
issued:
  v: 2025-02-10T17:00:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
specimen:
  l: IntegratedBETSpecimenBlock01
  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
specimen:
  l: IntegratedBETSpecimenBlock02
  reference:
    v: Specimen/IntegratedBETSpecimenBlock02
specimen:
  l: IntegratedBETSpecimenBlock03
  reference:
    v: Specimen/IntegratedBETSpecimenBlock03
specimen:
  l: IntegratedBETSpecimenBlock04
  reference:
    v: Specimen/IntegratedBETSpecimenBlock04
specimen:
  l: IntegratedBETSpecimenBlock05
  reference:
    v: Specimen/IntegratedBETSpecimenBlock05
specimen:
  l: IntegratedBETSpecimenBlock06
  reference:
    v: Specimen/IntegratedBETSpecimenBlock06
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
specimen:
  l: IntegratedBETSlideHE02
  reference:
    v: Specimen/IntegratedBETSlideHE02
specimen:
  l: IntegratedBETSlideER01
  reference:
    v: Specimen/IntegratedBETSlideER01
specimen:
  l: IntegratedBETSlidePR01
  reference:
    v: Specimen/IntegratedBETSlidePR01
specimen:
  l: IntegratedBETSlideHER2IHC01
  reference:
    v: Specimen/IntegratedBETSlideHER2IHC01
specimen:
  l: IntegratedBETSlideKi67-01
  reference:
    v: Specimen/IntegratedBETSlideKi67-01
specimen:
  l: IntegratedBETSlideCK18-01
  reference:
    v: Specimen/IntegratedBETSlideCK18-01
specimen:
  l: IntegratedBETSlidep40-01
  reference:
    v: Specimen/IntegratedBETSlidep40-01
specimen:
  l: IntegratedBETSlideECad-01
  reference:
    v: Specimen/IntegratedBETSlideECad-01
specimen:
  l: IntegratedBETSlideBlock02-HE01
  reference:
    v: Specimen/IntegratedBETSlideBlock02-HE01
specimen:
  l: IntegratedBETSlideBlock02-HE02
  reference:
    v: Specimen/IntegratedBETSlideBlock02-HE02
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
specimen:
  l: IntegratedBETSlideRR-Inferior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Inferior-HE01
specimen:
  l: IntegratedBETSlideRR-Medial-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Medial-HE01
specimen:
  l: IntegratedBETSlideRR-Lateral-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Lateral-HE01
specimen:
  l: IntegratedSLNSpecimenPart
  reference:
    v: Specimen/IntegratedSLNSpecimenPart
specimen:
  l: IntegratedSLNSpecimenBlock01
  reference:
    v: Specimen/IntegratedSLNSpecimenBlock01
specimen:
  l: IntegratedSLNSpecimenBlock02
  reference:
    v: Specimen/IntegratedSLNSpecimenBlock02
specimen:
  l: IntegratedSLNSlideHE01
  reference:
    v: Specimen/IntegratedSLNSlideHE01
specimen:
  l: IntegratedSLNSlideHE02
  reference:
    v: Specimen/IntegratedSLNSlideHE02
specimen:
  l: IntegratedSLNSlideHE03
  reference:
    v: Specimen/IntegratedSLNSlideHE03
specimen:
  l: IntegratedSLNSlideHE04
  reference:
    v: Specimen/IntegratedSLNSlideHE04
result:
  l: IntegratedMacroscopicGrouper
  reference:
    v: Observation/IntegratedMacroscopicGrouper
result:
  l: IntegratedDiagnosticConclusionGrouper
  reference:
    v: Observation/IntegratedDiagnosticConclusionGrouper
conclusion:
  v: Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c pN1mi(sn), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%. SLN 1/2 befallen (Mikrometastase 1,2 mm in SLN #1), keine extranodale Infiltration.

IntegratedBETSpecimenPart
type: Specimen
id:
  v: IntegratedBETSpecimenPart
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen IntegratedBETSpecimenPart Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: Placer Identifier/OP25_300_A, Filler Identifier/E_25_300_A accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Specimen from breast obtained by excision (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) request: ServiceRequest Pathology synoptic report Collections - Collector Collected[x] Method BodySite * Practitioner Thomas Richter 2025-02-05 10:00:00+0100 Wide local excision of breast lesion (procedure) Structure of lower outer quadrant of breast (body structure) Containers - Type Additive[x] * Specimen vial (physical object) Neutral buffered formalin (substance) note: BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm.
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: PLAC
  system:
    v: https://senologie.example-hospital.de/fhir/specimen/placer
    l: placer
  value:
    v: OP25_300_A
identifier:
  type:
    coding:
      system:
        v: http://terminology.hl7.org/CodeSystem/v2-0203
        l: v2-0203
      code:
        v: FILL
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/397199005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 397199005
    display:
      v: Specimen from breast obtained by excision (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
request:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
collection:
  collector:
    l: BreastSurgeonPractitioner
    reference:
      v: Practitioner/BreastSurgeonPractitioner
  collected: DateTime
    v: 2025-02-05T10:00:00+01:00
  method:
    coding: http://snomed.info/id/237371007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 237371007
      display:
        v: Wide local excision of breast lesion (procedure)
  body site:
    coding: http://snomed.info/id/33564002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 33564002
      display:
        v: Structure of lower outer quadrant of breast (body structure)
container:
  type:
    coding: http://snomed.info/id/434746001
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434746001
      display:
        v: Specimen vial (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/434162003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434162003
      display:
        v: Neutral buffered formalin (substance)
note:
  text:
    v: BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm.

IntegratedBETSpecimenBlock01
type: Specimen
id:
  v: IntegratedBETSpecimenBlock01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen IntegratedBETSpecimenBlock01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. Collections - Collected[x] Method * 2025-02-06 08:00:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe III Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:00:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_1
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1201985008
    display:
      v: Tissue block specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
collection:
  collected: DateTime
    v: 2025-02-06T08:00:00+01:00
  method:
    coding: http://snomed.info/id/787377000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787377000
      display:
        v: Gross examination and sampling of tissue specimen (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe III
  procedure:
    coding: http://snomed.info/id/787376009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 787376009
      display:
        v: Preparation of formalin fixed paraffin embedded tissue specimen (procedure)
  time: DateTime
    v: 2025-02-06T08:00:00+01:00
container:
  type:
    coding: http://snomed.info/id/706053007
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 706053007
      display:
        v: General specimen container (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 311731000
      display:
        v: Paraffin wax (substance)

IntegratedBETSpecimenBlock02
type: Specimen
id:
  v: IntegratedBETSpecimenBlock02
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Specimen IntegratedBETSpecimenBlock02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_2 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue block specimen (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. Collections - Collected[x] Method * 2025-02-06 08:10:00+0100 Gross examination and sampling of tissue specimen (procedure) Processings - Extension Description Procedure Time[x] * Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe V Preparation of formalin fixed paraffin embedded tissue specimen (procedure) 2025-02-06 08:10:00+0100 Containers - Type Additive[x] * General specimen container (physical object) Paraffin wax (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_2
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/1201985008
    system:
      v: http://snomed.info/sct
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parent:
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processing:
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  description:
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IntegratedBETSpecimenBlock03
type: Specimen
id:
  v: IntegratedBETSpecimenBlock03
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
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identifier:
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    l: befundbericht
  value:
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    l: befundbericht
  value:
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status:
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type:
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subject:
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parent:
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  reference:
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IntegratedBETSpecimenBlock04
type: Specimen
id:
  v: IntegratedBETSpecimenBlock04
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
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identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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    l: befundbericht
  value:
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status:
  v: available
type:
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subject:
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  reference:
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parent:
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  reference:
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    v: 2025-02-06T08:30:00+01:00
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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      system:
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    v: 2025-02-06T08:30:00+01:00
container:
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IntegratedBETSpecimenBlock05
type: Specimen
id:
  v: IntegratedBETSpecimenBlock05
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: generated
  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
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    system:
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      l: sct
    code:
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    display:
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subject:
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  reference:
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parent:
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  reference:
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  method:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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  time: DateTime
    v: 2025-02-06T08:40:00+01:00
container:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/311731000
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IntegratedBETSpecimenBlock06
type: Specimen
id:
  v: IntegratedBETSpecimenBlock06
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
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  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    code:
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    display:
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subject:
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  reference:
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parent:
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  reference:
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collection:
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    v: 2025-02-06T08:50:00+01:00
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      l: Temperaturbedingungen
    value: Range
  description:
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      system:
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IntegratedBETSlideHE01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
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      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
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  reference:
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parent:
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  reference:
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collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
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      display:
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  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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      display:
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container:
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IntegratedBETSlideHE02
type: Specimen
id:
  v: IntegratedBETSlideHE02
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
  coding: http://snomed.info/id/430856003
    system:
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      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
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  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock01
  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      system:
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        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 2)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
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      system:
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      display:
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    v: 2025-02-06T09:15:00+01:00
container:
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      system:
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IntegratedBETSlideER01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
  v: available
type:
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    system:
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    code:
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    display:
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subject:
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  reference:
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parent:
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  reference:
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collection:
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    v: 2025-02-06T09:30:00+01:00
  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
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        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: ER-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
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        l: sct
      code:
        v: 117617002
      display:
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  additive:
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    reference:
      v: Substance/IntegratedSubstanceER
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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      system:
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        l: sct
      code:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
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      display:
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IntegratedBETSlidePR01
type: Specimen
id:
  v: IntegratedBETSlidePR01
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlidePR01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_PR_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: PR-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_1_1_PR_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
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    system:
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      l: sct
    code:
      v: 430856003
    display:
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subject:
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  reference:
    v: Patient/Patient4
parent:
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  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
collection:
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    v: 2025-02-06T09:30:00+01:00
  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
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        l: sct
      code:
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      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: PR-Immunhistochemie
  procedure:
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      system:
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        l: sct
      code:
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      display:
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  additive:
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    reference:
      v: Substance/IntegratedSubstancePR
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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      system:
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        l: sct
      code:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
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      display:
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IntegratedBETSlideHER2IHC01
type: Specimen
id:
  v: IntegratedBETSlideHER2IHC01
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideHER2IHC01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_HER2_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HER2-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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      l: sct
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    display:
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subject:
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  reference:
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parent:
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  reference:
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collection:
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  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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  additive:
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    reference:
      v: Substance/IntegratedSubstanceHER2IHC
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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      system:
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      code:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
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      code:
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      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlideKi67-01
type: Specimen
id:
  v: IntegratedBETSlideKi67-01
meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideKi67-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_Ki67_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Ki-67-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    system:
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    display:
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subject:
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  reference:
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parent:
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  reference:
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collection:
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    v: 2025-02-06T09:30:00+01:00
  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
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        l: sct
      code:
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      display:
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  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Ki-67-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
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        l: sct
      code:
        v: 117617002
      display:
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  additive:
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    reference:
      v: Substance/IntegratedSubstanceKi67
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
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        l: sct
      code:
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      display:
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  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlideCK18-01
type: Specimen
id:
  v: IntegratedBETSlideCK18-01
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideCK18-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_CK18_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: CK18-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_1_1_CK18_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock01
  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:30:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: CK18-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: IntegratedSubstanceCK18
    reference:
      v: Substance/IntegratedSubstanceCK18
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlidep40-01
type: Specimen
id:
  v: IntegratedBETSlidep40-01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlidep40-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_p40_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: p40-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_1_1_p40_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock01
  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:30:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: p40-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: IntegratedSubstancep40
    reference:
      v: Substance/IntegratedSubstancep40
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
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    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlideECad-01
type: Specimen
id:
  v: IntegratedBETSlideECad-01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideECad-01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_1_1_ECad_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:30:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:30:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: E-Cadherin-Immunhistochemie procedure: Immunohistochemistry procedure (procedure) additive: Substance Tissue stain (substance) time: 2025-02-06 10:00:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_A_1_1_ECad_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock01
  reference:
    v: Specimen/IntegratedBETSpecimenBlock01
collection:
  collected: DateTime
    v: 2025-02-06T09:30:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:30:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: E-Cadherin-Immunhistochemie
  procedure:
    coding: http://snomed.info/id/117617002
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 117617002
      display:
        v: Immunohistochemistry procedure (procedure)
  additive:
    l: IntegratedSubstanceECadherin
    reference:
      v: Substance/IntegratedSubstanceECadherin
  time: DateTime
    v: 2025-02-06T10:00:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlideBlock02-HE01
type: Specimen
id:
  v: IntegratedBETSlideBlock02-HE01
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideBlock02-HE01 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_2_1_HE_01 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 1) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
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    l: befundbericht
  value:
    v: E_25_300_A_2_1_HE_01
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
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subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock02
  reference:
    v: Specimen/IntegratedBETSpecimenBlock02
collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 1)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
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        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
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        l: sct
      code:
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      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedBETSlideBlock02-HE02
type: Specimen
id:
  v: IntegratedBETSlideBlock02-HE02
meta:
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedBETSlideBlock02-HE02 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_A_2_1_HE_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 2) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
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accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedBETSpecimenBlock02
  reference:
    v: Specimen/IntegratedBETSpecimenBlock02
collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 2)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
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        l: sct
      code:
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      display:
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      display:
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IntegratedBETSlideRR-Superior-HE01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    system:
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    code:
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    display:
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subject:
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  reference:
    v: Patient/Patient4
parent:
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  reference:
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collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      system:
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        l: sct
      code:
        v: 13283003
      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
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  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      display:
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IntegratedBETSlideRR-Inferior-HE01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
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  div:
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identifier:
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    l: befundbericht
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    display:
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subject:
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  reference:
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parent:
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  reference:
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collection:
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  method:
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      system:
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      code:
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
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  time: DateTime
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container:
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      system:
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        l: sct
      code:
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      display:
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      system:
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      code:
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      display:
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IntegratedBETSlideRR-Medial-HE01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
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    system:
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      l: sct
    code:
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    display:
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subject:
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  reference:
    v: Patient/Patient4
parent:
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  reference:
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collection:
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    v: 2025-02-06T09:00:00+01:00
  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
    coding: http://snomed.info/id/434472006
      system:
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        l: sct
      code:
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      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
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      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
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  time: DateTime
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container:
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      system:
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        l: sct
      code:
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      display:
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      system:
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        l: sct
      code:
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      display:
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IntegratedBETSlideRR-Lateral-HE01
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-specimen
  profile:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
    v: extensions
  div:
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identifier:
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    l: befundbericht
  value:
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accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    system:
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      l: sct
    code:
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    display:
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subject:
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  reference:
    v: Patient/Patient4
parent:
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  reference:
    v: Specimen/IntegratedBETSpecimenBlock06
collection:
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  method:
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      system:
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        l: sct
      code:
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      display:
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processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
    coding: http://snomed.info/id/434472006
      system:
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        l: sct
      code:
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      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
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      l: Temperaturbedingungen
    value: Range
  description:
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  procedure:
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      system:
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        l: sct
      code:
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      display:
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  time: DateTime
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container:
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      system:
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        l: sct
      code:
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      display:
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    coding: http://snomed.info/id/430862008
      system:
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        l: sct
      code:
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      display:
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IntegratedSLNSpecimenPart
type: Specimen
id:
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meta:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
  status:
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  div:
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identifier:
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      code:
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    l: placer
  value:
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identifier:
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        l: v2-0203
      code:
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    l: befundbericht
  value:
    v: E_25_300_B
accession identifier:
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    l: befundbericht
  value:
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status:
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type:
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    system:
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      l: sct
    code:
      v: 258589002
    display:
      v: Lymph node specimen (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
request:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
collection:
  collector:
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    reference:
      v: Practitioner/BreastSurgeonPractitioner
  collected: DateTime
    v: 2025-02-05T10:30:00+01:00
  method:
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      system:
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        l: sct
      code:
        v: 396487001
      display:
        v: Sentinel lymph node biopsy (procedure)
  body site:
    coding: http://snomed.info/id/68171009
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 68171009
      display:
        v: Axillary lymph node structure (body structure)
container:
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    coding: http://snomed.info/id/434746001
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434746001
      display:
        v: Specimen vial (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/434162003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434162003
      display:
        v: Neutral buffered formalin (substance)
note:
  text:
    v: Sentinel-Lymphknoten-Exzisat linke Axilla, 2 SLN identifiziert (Patentblau-markiert). SLN #1: 12 x 8 x 6 mm, SLN #2: 10 x 7 x 5 mm. Beide halbiert und vollständig eingebettet.

IntegratedSLNSpecimenBlock01
type: Specimen
id:
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IntegratedSLNSpecimenBlock02
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text:
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IntegratedSLNSlideHE01
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text:
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identifier:
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IntegratedSLNSlideHE02
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text:
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IntegratedSLNSlideHE03
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id:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
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status:
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IntegratedSLNSlideHE04
type: Specimen
id:
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    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/SpecimenCore
text:
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    v: extensions
  div:
    v: Generated Narrative: Specimen IntegratedSLNSlideHE04 Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0 identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300_B_2_1_HE_02 accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_300 status: Available type: Tissue section (specimen) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_B_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) Collections - Collected[x] Method * 2025-02-06 09:00:00+0100 Tissue processing technique (procedure) processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: Schnittherstellung (Schnittstufe 2) procedure: Sectioning of tissue block (procedure) time: 2025-02-06 09:00:00+0100 processing MII EX Biobank Temperaturbedingungen: 20-25 °C description: HE-Färbung procedure: Hematoxylin and eosin stain method (procedure) time: 2025-02-06 09:15:00+0100 Containers - Type Additive[x] * Microscope slide (physical object) Microscope slide mounting medium (substance)
identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300_B_2_1_HE_02
accession identifier:
  system:
    v: https://pathologie.example-hospital.de/fhir/fn/befundbericht
    l: befundbericht
  value:
    v: E_25_300
status:
  v: available
type:
  coding: http://snomed.info/id/430856003
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 430856003
    display:
      v: Tissue section (specimen)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
parent:
  l: IntegratedSLNSpecimenBlock02
  reference:
    v: Specimen/IntegratedSLNSpecimenBlock02
collection:
  collected: DateTime
    v: 2025-02-06T09:00:00+01:00
  method:
    coding: http://snomed.info/id/13283003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 13283003
      display:
        v: Tissue processing technique (procedure)
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: Schnittherstellung (Schnittstufe 2)
  procedure:
    coding: http://snomed.info/id/434472006
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 434472006
      display:
        v: Sectioning of tissue block (procedure)
  time: DateTime
    v: 2025-02-06T09:00:00+01:00
processing:
  extension:
    url:
      v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Temperaturbedingungen
      l: Temperaturbedingungen
    value: Range
  description:
    v: HE-Färbung
  procedure:
    coding: http://snomed.info/id/104210008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 104210008
      display:
        v: Hematoxylin and eosin stain method (procedure)
  time: DateTime
    v: 2025-02-06T09:15:00+01:00
container:
  type:
    coding: http://snomed.info/id/433466003
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 433466003
      display:
        v: Microscope slide (physical object)
  additive: CodeableConcept
    coding: http://snomed.info/id/430862008
      system:
        v: http://snomed.info/sct
        l: sct
      code:
        v: 430862008
      display:
        v: Microscope slide mounting medium (substance)

IntegratedSubstanceER
type: Substance
id:
  v: IntegratedSubstanceER
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstanceER Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Estrogen Receptor (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Estrogen Receptor (Dako Omnis)

IntegratedSubstancePR
type: Substance
id:
  v: IntegratedSubstancePR
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstancePR Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Progesterone Receptor (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Progesterone Receptor (Dako Omnis)

IntegratedSubstanceHER2IHC
type: Substance
id:
  v: IntegratedSubstanceHER2IHC
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstanceHER2IHC Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: VENTANA HER2 (4B5), Roche
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: VENTANA HER2 (4B5), Roche

IntegratedSubstanceKi67
type: Substance
id:
  v: IntegratedSubstanceKi67
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstanceKi67 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Ki-67 Antigen (Dako Omnis)
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Ki-67 Antigen (Dako Omnis)

IntegratedSubstanceCK18
type: Substance
id:
  v: IntegratedSubstanceCK18
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstanceCK18 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: Cytokeratin 18 (DC10), Dako Omnis
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: Cytokeratin 18 (DC10), Dako Omnis

IntegratedSubstancep40
type: Substance
id:
  v: IntegratedSubstancep40
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstancep40 Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: p40 (BC28), Biocare Medical
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: p40 (BC28), Biocare Medical

IntegratedSubstanceECadherin
type: Substance
id:
  v: IntegratedSubstanceECadherin
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-biobank/StructureDefinition/Substance
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Substance IntegratedSubstanceECadherin Profile: MII PR Biobank Substance Additiv version: 2026.0.0 status: Active category: Chemical code: Tissue stain (substance) description: E-Cadherin (NCH-38), Dako Omnis
status:
  v: active
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/substance-category
      l: substance-category
    code:
      v: chemical
    display:
      v: Chemical
code:
  coding: http://snomed.info/id/45389009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 45389009
    display:
      v: Tissue stain (substance)
description:
  v: E-Cadherin (NCH-38), Dako Omnis

IntegratedMacroscopicGrouper
type: Observation
id:
  v: IntegratedMacroscopicGrouper
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroscopicGrouper Profile: MII PR Patho Macroscopic Grouper version: 2026.0.0 status: Final category: Laboratory code: Pathology report gross observation Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann hasMember: Observation Specimen size.maximum dimension in Breast tumor Observation Specimen size additional dimension 1 in Breast tumor Observation Specimen size additional dimension 2 in Breast tumor Observation Specimen wt Tiss Qn Observation Quadrant Breast Observation Radial position in breast [Angle] in Breast cancer specimen Observation Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity) Observation Number of paraffin embedded tissue blocks examined from excised specimen (observable entity) Observation Length of tissue core(s) Observation Length of tissue core(s) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_LN-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
code:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
has member:
  l: IntegratedMacroLength
  reference:
    v: Observation/IntegratedMacroLength
has member:
  l: IntegratedMacroWidth
  reference:
    v: Observation/IntegratedMacroWidth
has member:
  l: IntegratedMacroDepth
  reference:
    v: Observation/IntegratedMacroDepth
has member:
  l: IntegratedMacroWeight
  reference:
    v: Observation/IntegratedMacroWeight
has member:
  l: IntegratedMacroQuadrant
  reference:
    v: Observation/IntegratedMacroQuadrant
has member:
  l: IntegratedMacroClock
  reference:
    v: Observation/IntegratedMacroClock
has member:
  l: IntegratedMacroDistanceNipple
  reference:
    v: Observation/IntegratedMacroDistanceNipple
has member:
  l: IntegratedMacroBlockCount
  reference:
    v: Observation/IntegratedMacroBlockCount
has member:
  l: IntegratedMacroSLN1Size
  reference:
    v: Observation/IntegratedMacroSLN1Size
has member:
  l: IntegratedMacroSLN2Size
  reference:
    v: Observation/IntegratedMacroSLN2Size
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
derived from:
  l: IntegratedQRLymphNode
  reference:
    v: QuestionnaireResponse/IntegratedQRLymphNode

IntegratedMacroLength
type: Observation
id:
  v: IntegratedMacroLength
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroLength Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße1 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 42 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44629-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44629-4
    display:
      v: Specimen size.maximum dimension in Breast tumor
  text:
    v: ProbeGröße1
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 42
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroWidth
type: Observation
id:
  v: IntegratedMacroWidth
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroWidth Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße2 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 35 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44630-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44630-2
    display:
      v: Specimen size additional dimension 1 in Breast tumor
  text:
    v: ProbeGröße2
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 35
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroDepth
type: Observation
id:
  v: IntegratedMacroDepth
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroDepth Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: ProbeGröße3 subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 18 mm (Details: UCUM codemm = 'mm') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44631-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44631-0
    display:
      v: Specimen size additional dimension 2 in Breast tumor
  text:
    v: ProbeGröße3
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 18
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroWeight
type: Observation
id:
  v: IntegratedMacroWeight
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroWeight Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Gewicht der Probe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 10 g (Details: UCUM codeg = 'g') bodySite: Breast structure (body structure) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/29638-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 29638-4
    display:
      v: Specimen wt Tiss Qn
  text:
    v: Gewicht der Probe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 10
  unit:
    v: g
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: g
body site:
  coding: http://snomed.info/id/76752008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 76752008
    display:
      v: Breast structure (body structure)
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroQuadrant
type: Observation
id:
  v: IntegratedMacroQuadrant
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroQuadrant Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Quadrantenlokalisaion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: Unterer äußerer Quadrant specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/42799-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 42799-7
    display:
      v: Quadrant Breast
  text:
    v: Quadrantenlokalisaion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/33564002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 33564002
    display:
      v: Structure of lower outer quadrant of breast (body structure)
  text:
    v: Unterer äußerer Quadrant
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroClock
type: Observation
id:
  v: IntegratedMacroClock
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroClock Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Zifferblattlokalisation subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 5 o'clock (Details: UCUM code{clock position} = '{clock position}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/85332-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85332-5
    display:
      v: Radial position in breast [Angle] in Breast cancer specimen
  coding: http://snomed.info/id/3980001000004105
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3980001000004105
    display:
      v: Radial location of primary malignant neoplasm in excised breast specimen (observable entity)
  text:
    v: Zifferblattlokalisation
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 5
  unit:
    v: o'clock
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {clock position}
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroDistanceNipple
type: Observation
id:
  v: IntegratedMacroDistanceNipple
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroDistanceNipple Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Abstand von der Mamille subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 50 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/1240401000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240401000
    display:
      v: Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity)
  text:
    v: Abstand von der Mamille
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 50
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroBlockCount
type: Observation
id:
  v: IntegratedMacroBlockCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroBlockCount Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: Anzahl Paraffinblöcke subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 6 Blöcke (Details: UCUM code{blocks} = '{blocks}') specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: http://snomed.info/id/3100001000004109
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3100001000004109
    display:
      v: Number of paraffin embedded tissue blocks examined from excised specimen (observable entity)
  text:
    v: Anzahl Paraffinblöcke
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 6
  unit:
    v: Blöcke
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {blocks}
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMacroSLN1Size
type: Observation
id:
  v: IntegratedMacroSLN1Size
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroSLN1Size Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: SLN #1 Größe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 12 x 8 x 6 mm, Patentblau-markiert bodySite: Axillary lymph node structure (body structure) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_B_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_LN-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44619-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44619-5
    display:
      v: Length of tissue core(s)
  text:
    v: SLN #1 Größe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: 12 x 8 x 6 mm, Patentblau-markiert
body site:
  coding: http://snomed.info/id/68171009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 68171009
    display:
      v: Axillary lymph node structure (body structure)
specimen:
  l: IntegratedSLNSpecimenBlock01
  reference:
    v: Specimen/IntegratedSLNSpecimenBlock01
derived from:
  l: IntegratedQRLymphNode
  reference:
    v: QuestionnaireResponse/IntegratedQRLymphNode

IntegratedMacroSLN2Size
type: Observation
id:
  v: IntegratedMacroSLN2Size
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMacroSLN2Size Profile: MII PR Patho Finding version: 2026.0.0 status: Final category: Laboratory, Pathology report gross observation Narrative code: SLN #2 Größe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-06 08:30:00+0100 performer: Practitioner Elisabeth Hoffmann value: 10 x 7 x 5 mm, Patentblau-markiert bodySite: Axillary lymph node structure (body structure) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_B_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue block specimen (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_LN-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22634-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22634-0
code:
  coding: https://loinc.org/rdf/44619-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44619-5
    display:
      v: Length of tissue core(s)
  text:
    v: SLN #2 Größe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-06T08:30:00+01:00
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: 10 x 7 x 5 mm, Patentblau-markiert
body site:
  coding: http://snomed.info/id/68171009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 68171009
    display:
      v: Axillary lymph node structure (body structure)
specimen:
  l: IntegratedSLNSpecimenBlock02
  reference:
    v: Specimen/IntegratedSLNSpecimenBlock02
derived from:
  l: IntegratedQRLymphNode
  reference:
    v: QuestionnaireResponse/IntegratedQRLymphNode

IntegratedDiagnosticConclusionGrouper
type: Observation
id:
  v: IntegratedDiagnosticConclusionGrouper
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedDiagnosticConclusionGrouper Profile: MII PR Patho Diagnostic Conclusion Grouper version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory code: Pathology report final diagnosis Narrative subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann hasMember: Observation Surgery procedure Observation Specimen type Observation Specimen laterality (observable entity) Observation Body structure included in specimen [Anatomy] in Specimen Observation Qualitative distribution of primary malignant neoplasm of breast in excised breast specimen (observable entity) Observation Inv comp size max dim BT Observation Size.maximum dimension in Tumor Observation Histo type BT Observation Histology type in Cancer specimen Narrative Observation Histologic grade [Score] in Breast cancer specimen by Nottingham Observation Glandular differentiation [Score] in Breast cancer specimen by Nottingham Observation Nuclear pleomorphism in Breast tumor by Nottingham Observation Number of mitoses per 10 high power fields (observable entity) Observation Mitotic rate [Score] in Breast cancer specimen by Nottingham Observation Nottingham total score of primary malignant neoplasm of breast (observable entity) Observation DCIS intraduct ext Br ca spec Ql Micro Observation Nuclear grade of ductal carcinoma in situ of breast (observable entity) Observation Growth pattern of DCIS [Type] in Breast cancer specimen by Light microscopy Observation DCIS necrosis [Type] in Breast cancer specimen by Light microscopy Observation Adjacent structure invaded by tumor [Anatomy] in Breast cancer specimen by Light microscopy Observation Margin involved BT Observation IC uninv marg closest BT Observation IC uninv marg dist closest BT Observation Surgical margin DCIS involvement [Presence] in Breast cancer specimen by Light micros…
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
code:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
has member:
  l: IntegratedOperativeProcedure
  reference:
    v: Observation/IntegratedOperativeProcedure
has member:
  l: IntegratedMaterialType
  reference:
    v: Observation/IntegratedMaterialType
has member:
  l: IntegratedLaterality
  reference:
    v: Observation/IntegratedLaterality
has member:
  l: IntegratedAttachedTissue
  reference:
    v: Observation/IntegratedAttachedTissue
has member:
  l: IntegratedFocality
  reference:
    v: Observation/IntegratedFocality
has member:
  l: IntegratedMaxDiameterInvasive
  reference:
    v: Observation/IntegratedMaxDiameterInvasive
has member:
  l: IntegratedMaxOverallDiameter
  reference:
    v: Observation/IntegratedMaxOverallDiameter
has member:
  l: IntegratedHistologicalType
  reference:
    v: Observation/IntegratedHistologicalType
has member:
  l: IntegratedMorphologyFreeText
  reference:
    v: Observation/IntegratedMorphologyFreeText
has member:
  l: IntegratedNottinghamGrade
  reference:
    v: Observation/IntegratedNottinghamGrade
has member:
  l: IntegratedTubuleScore
  reference:
    v: Observation/IntegratedTubuleScore
has member:
  l: IntegratedNuclearPleomorphism
  reference:
    v: Observation/IntegratedNuclearPleomorphism
has member:
  l: IntegratedMitosisCount
  reference:
    v: Observation/IntegratedMitosisCount
has member:
  l: IntegratedMitoticRateScore
  reference:
    v: Observation/IntegratedMitoticRateScore
has member:
  l: IntegratedElstonEllisScore
  reference:
    v: Observation/IntegratedElstonEllisScore
has member:
  l: IntegratedAssociatedDCIS
  reference:
    v: Observation/IntegratedAssociatedDCIS
has member:
  l: IntegratedDCISGrade
  reference:
    v: Observation/IntegratedDCISGrade
has member:
  l: IntegratedDCISArchitecture
  reference:
    v: Observation/IntegratedDCISArchitecture
has member:
  l: IntegratedDCISNecrosis
  reference:
    v: Observation/IntegratedDCISNecrosis
has member:
  l: IntegratedTumorExtent
  reference:
    v: Observation/IntegratedTumorExtent
has member:
  l: IntegratedMarginStatusInvasive
  reference:
    v: Observation/IntegratedMarginStatusInvasive
has member:
  l: IntegratedClosestMargin
  reference:
    v: Observation/IntegratedClosestMargin
has member:
  l: IntegratedMinDistanceInvasive
  reference:
    v: Observation/IntegratedMinDistanceInvasive
has member:
  l: IntegratedMarginStatusNonInvasive
  reference:
    v: Observation/IntegratedMarginStatusNonInvasive
has member:
  l: IntegratedMinDistanceNonInvasive
  reference:
    v: Observation/IntegratedMinDistanceNonInvasive
has member:
  l: IntegratedLVI
  reference:
    v: Observation/IntegratedLVI
has member:
  l: IntegratedMicrocalcification
  reference:
    v: Observation/IntegratedMicrocalcification
has member:
  l: IntegratedERStatus
  reference:
    v: Observation/IntegratedERStatus
has member:
  l: IntegratedERPercentage
  reference:
    v: Observation/IntegratedERPercentage
has member:
  l: IntegratedERIntensity
  reference:
    v: Observation/IntegratedERIntensity
has member:
  l: IntegratedPRStatus
  reference:
    v: Observation/IntegratedPRStatus
has member:
  l: IntegratedPRPercentage
  reference:
    v: Observation/IntegratedPRPercentage
has member:
  l: IntegratedPRIntensity
  reference:
    v: Observation/IntegratedPRIntensity
has member:
  l: IntegratedHER2IHC
  reference:
    v: Observation/IntegratedHER2IHC
has member:
  l: IntegratedHER2ISH
  reference:
    v: Observation/IntegratedHER2ISH
has member:
  l: IntegratedHER2Overall
  reference:
    v: Observation/IntegratedHER2Overall
has member:
  l: IntegratedKi67
  reference:
    v: Observation/IntegratedKi67
has member:
  l: IntegratedPT
  reference:
    v: Observation/IntegratedPT
has member:
  l: IntegratedBETComment
  reference:
    v: Observation/IntegratedBETComment
has member:
  l: IntegratedLymphNodeProcedure
  reference:
    v: Observation/IntegratedLymphNodeProcedure

IntegratedOperativeProcedure
type: Observation
id:
  v: IntegratedOperativeProcedure
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedOperativeProcedure Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Operatives Verfahren subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Brusterhaltende Therapie (BET) specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/29306-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 29306-8
    display:
      v: Surgery procedure
  coding: http://snomed.info/id/2620001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2620001000004108
    display:
      v: Specimen collection procedure (observable entity)
  text:
    v: Operatives Verfahren
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/237371007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 237371007
    display:
      v: Wide local excision of breast lesion (procedure)
  text:
    v: Brusterhaltende Therapie (BET)
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMaterialType
type: Observation
id:
  v: IntegratedMaterialType
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMaterialType Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Materialart subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Exzisionspräparat specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/66746-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 66746-9
    display:
      v: Specimen type
  text:
    v: Materialart
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Exzisionspräparat
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedLaterality
type: Observation
id:
  v: IntegratedLaterality
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedLaterality Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Seitenlokalisation der Probe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Links specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/384727002
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 384727002
    display:
      v: Specimen laterality (observable entity)
  text:
    v: Seitenlokalisation der Probe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/7771000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 7771000
    display:
      v: Left (qualifier value)
  text:
    v: Links
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedAttachedTissue
type: Observation
id:
  v: IntegratedAttachedTissue
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedAttachedTissue Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Material/anhängendes Gewebe subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Haut specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. 42 × 35 × 18 mm, 10 g. Haut anhängend, Drahthäkchen in situ. Lamellierung in 8 Scheiben à 5 mm. Schnittfläche: grau-weißlicher Herdbefund zentral in Scheibe III–V, ca. 18 mm. derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85298-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85298-8
    display:
      v: Body structure included in specimen [Anatomy] in Specimen
  text:
    v: Material/anhängendes Gewebe
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/39937001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 39937001
    display:
      v: Skin structure (body structure)
  text:
    v: Haut
specimen:
  l: IntegratedBETSpecimenPart
  reference:
    v: Specimen/IntegratedBETSpecimenPart
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedFocality
type: Observation
id:
  v: IntegratedFocality
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedFocality Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: (Multi)fokalität subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Unifokal specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1157128007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1157128007
    display:
      v: Qualitative distribution of primary malignant neoplasm of breast in excised breast specimen (observable entity)
  text:
    v: (Multi)fokalität
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Unifokal
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMaxDiameterInvasive
type: Observation
id:
  v: IntegratedMaxDiameterInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMaxDiameterInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Maximaler Durchmesser invasives Karzinom subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 18 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44635-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44635-1
    display:
      v: Inv comp size max dim BT
  coding: http://snomed.info/id/200001000004104
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 200001000004104
    display:
      v: Greatest length dimension of excised primary malignant neoplasm (observable entity)
  text:
    v: Maximaler Durchmesser invasives Karzinom
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 18
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMaxOverallDiameter
type: Observation
id:
  v: IntegratedMaxOverallDiameter
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMaxOverallDiameter Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Maximaler Gesamtdurchmesser der Läsion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 22 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/33728-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33728-7
    display:
      v: Size.maximum dimension in Tumor
  text:
    v: Maximaler Gesamtdurchmesser der Läsion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 22
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedHistologicalType
type: Observation
id:
  v: IntegratedHistologicalType
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedHistologicalType Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histologischer Tumortyp WHO subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Invasives duktales Karzinom (NST) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44638-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44638-5
    display:
      v: Histo type BT
  coding: http://snomed.info/id/1660001000004100
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1660001000004100
    display:
      v: Histologic type of primary malignant neoplasm of breast (observable entity)
  text:
    v: Histologischer Tumortyp WHO
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding:
    system:
      v: urn:oid:2.16.840.1.113883.6.43.1
      l: 2.16.840.1.113883.6.43.1
    code:
      v: 8500/3
    display:
      v: Invasives duktales Karzinom (NST)
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMorphologyFreeText
type: Observation
id:
  v: IntegratedMorphologyFreeText
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMorphologyFreeText Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Morphologie Freitext subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion. specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/33731-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 33731-1
    display:
      v: Histology type in Cancer specimen Narrative
  text:
    v: Morphologie Freitext
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: String
  v: Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion.
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedNottinghamGrade
type: Observation
id:
  v: IntegratedNottinghamGrade
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedNottinghamGrade Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Histologischer Tumorgrad (Elston-Ellis-Grad) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nottingham Grad 2 (Score 6) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44648-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44648-4
    display:
      v: Histologic grade [Score] in Breast cancer specimen by Nottingham
  text:
    v: Histologischer Tumorgrad (Elston-Ellis-Grad)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/1155703007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1155703007
    display:
      v: G2: Moderately differentiated histologic grade (qualifier value)
  text:
    v: Nottingham Grad 2 (Score 6)
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedTubuleScore
type: Observation
id:
  v: IntegratedTubuleScore
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedTubuleScore Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Tubulus Scorewert subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 3 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85321-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85321-8
    display:
      v: Glandular differentiation [Score] in Breast cancer specimen by Nottingham
  text:
    v: Tubulus Scorewert
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 3
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedNuclearPleomorphism
type: Observation
id:
  v: IntegratedNuclearPleomorphism
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedNuclearPleomorphism Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Kernpleomorphie Scorewert subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 2 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44645-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44645-0
    display:
      v: Nuclear pleomorphism in Breast tumor by Nottingham
  text:
    v: Kernpleomorphie Scorewert
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 2
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMitosisCount
type: Observation
id:
  v: IntegratedMitosisCount
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMitosisCount Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mitosezahl subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 4 per 10 HPF (Details: UCUM code{HPF} = '{HPF}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/406094009
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 406094009
    display:
      v: Number of mitoses per 10 high power fields (observable entity)
  text:
    v: Mitosezahl
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 4
  unit:
    v: per 10 HPF
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {HPF}
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMitoticRateScore
type: Observation
id:
  v: IntegratedMitoticRateScore
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMitoticRateScore Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mitoserate Scorewert subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 1 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85300-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85300-2
    display:
      v: Mitotic rate [Score] in Breast cancer specimen by Nottingham
  text:
    v: Mitoserate Scorewert
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 1
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedElstonEllisScore
type: Observation
id:
  v: IntegratedElstonEllisScore
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedElstonEllisScore Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Elston-Ellis-Summenscore subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 6 score (Details: UCUM code{score} = '{score}') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1287461000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1287461000
    display:
      v: Nottingham total score of primary malignant neoplasm of breast (observable entity)
  text:
    v: Elston-Ellis-Summenscore
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 6
  unit:
    v: score
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: {score}
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedAssociatedDCIS
type: Observation
id:
  v: IntegratedAssociatedDCIS
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedAssociatedDCIS Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Klassifikation eines assoziiertes DCIS subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: DCIS vorhanden specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85336-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85336-6
    display:
      v: DCIS intraduct ext Br ca spec Ql Micro
  text:
    v: Klassifikation eines assoziiertes DCIS
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: DCIS vorhanden
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedDCISGrade
type: Observation
id:
  v: IntegratedDCISGrade
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedDCISGrade Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Kerngrading / WHO-Grading nichtinvasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Intermediär (Grad 2) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/2890001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2890001000004108
    display:
      v: Nuclear grade of ductal carcinoma in situ of breast (observable entity)
  text:
    v: Kerngrading / WHO-Grading nichtinvasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Intermediär (Grad 2)
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedDCISArchitecture
type: Observation
id:
  v: IntegratedDCISArchitecture
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedDCISArchitecture Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: DCIS Architektur subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: kribriformer Typ specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85302-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85302-8
    display:
      v: Growth pattern of DCIS [Type] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/3400001000004108
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3400001000004108
    display:
      v: Architectural pattern of ductal carcinoma in situ in breast (observable entity)
  text:
    v: DCIS Architektur
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/443987001
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 443987001
    display:
      v: Cribriform neoplasm pattern (finding)
  text:
    v: kribriformer Typ
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedDCISNecrosis
type: Observation
id:
  v: IntegratedDCISNecrosis
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedDCISNecrosis Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Nekrosen subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Fokal (Komedo-Nekrosen) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85340-8
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85340-8
    display:
      v: DCIS necrosis [Type] in Breast cancer specimen by Light microscopy
  text:
    v: Nekrosen
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Fokal (Komedo-Nekrosen)
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedTumorExtent
type: Observation
id:
  v: IntegratedTumorExtent
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedTumorExtent Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Tumorausdehnung subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Auf Brustdrüse beschränkt specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85322-6
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85322-6
    display:
      v: Adjacent structure invaded by tumor [Anatomy] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/396645007
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 396645007
    display:
      v: Status of extension by tumor (observable entity)
  coding: http://snomed.info/id/3280001000004106
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 3280001000004106
    display:
      v: Anatomic location directly invaded by primary malignant neoplasm of breast (observable entity)
  text:
    v: Tumorausdehnung
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Auf Brustdrüse beschränkt
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMarginStatusInvasive
type: Observation
id:
  v: IntegratedMarginStatusInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMarginStatusInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Resektionsrandstatus invasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht befallen (R0) specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_3_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44669-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44669-0
    display:
      v: Margin involved BT
  coding: http://snomed.info/id/371488000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371488000
    display:
      v: Presence of neoplasm at excised surgical margin (observable entity)
  coding: http://snomed.info/id/1240395000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240395000
    display:
      v: Surgical margin involved by primary malignant neoplasm of breast in excised breast specimen (observable entity)
  text:
    v: Resektionsrandstatus invasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht befallen (R0)
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedClosestMargin
type: Observation
id:
  v: IntegratedClosestMargin
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedClosestMargin Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Richtung des nächsten tumorfreien RR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Posterior specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_3_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44674-0
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44674-0
    display:
      v: IC uninv marg closest BT
  coding: http://snomed.info/id/170001000004107
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 170001000004107
    display:
      v: Surgical margin closest to malignant neoplasm in excised specimen of breast (observable entity)
  text:
    v: Richtung des nächsten tumorfreien RR
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  text:
    v: Posterior
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMinDistanceInvasive
type: Observation
id:
  v: IntegratedMinDistanceInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMinDistanceInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mindestabstand des invasiven Tumor zum nächstgelegenen Resektionsrand subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 5 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_3_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44672-4
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44672-4
    display:
      v: IC uninv marg dist closest BT
  coding: http://snomed.info/id/373120008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 373120008
    display:
      v: Distance of invasive carcinoma of breast from closest surgical margin in excised breast specimen (observable entity)
  text:
    v: Mindestabstand des invasiven Tumor zum nächstgelegenen Resektionsrand
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 5
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMarginStatusNonInvasive
type: Observation
id:
  v: IntegratedMarginStatusNonInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMarginStatusNonInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Resektionsrandstatus nichtinvasiv subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht befallen specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_3_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85334-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85334-1
    display:
      v: Surgical margin DCIS involvement [Presence] in Breast cancer specimen by Light microscopy
  coding: http://snomed.info/id/384705006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 384705006
    display:
      v: Presence of ductal carcinoma in situ at surgical margin in excised specimen of breast (observable entity)
  text:
    v: Resektionsrandstatus nichtinvasiv
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht befallen
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMinDistanceNonInvasive
type: Observation
id:
  v: IntegratedMinDistanceNonInvasive
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMinDistanceNonInvasive Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Mindestabstand vom RR zum nichtinvasiven Tumor subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 3 mm (Details: UCUM codemm = 'mm') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_3_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/44673-2
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 44673-2
    display:
      v: DCIS.uninv marg dist.closest BT
  text:
    v: Mindestabstand vom RR zum nichtinvasiven Tumor
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 3
  unit:
    v: mm
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: mm
specimen:
  l: IntegratedBETSlideRR-Superior-HE01
  reference:
    v: Specimen/IntegratedBETSlideRR-Superior-HE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedLVI
type: Observation
id:
  v: IntegratedLVI
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedLVI Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Peritumorale Gefäßinvasion subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Nicht nachgewiesen specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/59544-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 59544-7
    display:
      v: Lymph-vascular invasion Ca spec
  coding: http://snomed.info/id/371512006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 371512006
    display:
      v: Presence of direct invasion by primary malignant neoplasm to lymphatic vessel and/or small blood vessel (observable entity)
  text:
    v: Peritumorale Gefäßinvasion
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/2667000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 2667000
    display:
      v: Absent (qualifier value)
  text:
    v: Nicht nachgewiesen
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedMicrocalcification
type: Observation
id:
  v: IntegratedMicrocalcification
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedMicrocalcification Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Presence of microcalcification in excised breast specimen (observable entity) subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Microcalcifications present in DCIS specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: http://snomed.info/id/1240404008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1240404008
    display:
      v: Presence of microcalcification in excised breast specimen (observable entity)
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: LA27826-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: LA27826-9
    display:
      v: Microcalcifications present in DCIS
specimen:
  l: IntegratedBETSlideHE01
  reference:
    v: Specimen/IntegratedBETSlideHE01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection

IntegratedERStatus
type: Observation
id:
  v: IntegratedERStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedERStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Hormonrezeptorstatus Östrogen subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/16112-5
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 16112-5
    display:
      v: Estrogen receptor [Interpretation] in Tissue
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Hormonrezeptorstatus Östrogen
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: Positiv
specimen:
  l: IntegratedBETSlideER01
  reference:
    v: Specimen/IntegratedBETSlideER01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

IntegratedERPercentage
type: Observation
id:
  v: IntegratedERPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedERPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: PP ER subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 90 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85329-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85329-1
    display:
      v: Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234804006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234804006
    display:
      v: Percent of cells with estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: PP ER
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 90
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: IntegratedBETSlideER01
  reference:
    v: Specimen/IntegratedBETSlideER01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

IntegratedERIntensity
type: Observation
id:
  v: IntegratedERIntensity
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedERIntensity Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Färbeintensität ER subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Stark specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] ESR1
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85310-1
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85310-1
    display:
      v: Estrogen receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1236874005
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1236874005
    display:
      v: Intensity of stain of estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Färbeintensität ER
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/24484000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 24484000
    display:
      v: Severe (severity modifier) (qualifier value)
  text:
    v: Stark
specimen:
  l: IntegratedBETSlideER01
  reference:
    v: Specimen/IntegratedBETSlideER01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:3467
      display:
        v: ESR1

IntegratedPRStatus
type: Observation
id:
  v: IntegratedPRStatus
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedPRStatus Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Hormonrezeptorstatus Progesteron subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Positiv specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/16113-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 16113-3
    display:
      v: Progesterone receptor [Interpretation] in Tissue
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: Hormonrezeptorstatus Progesteron
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: CodeableConcept
  coding: http://snomed.info/id/52101004
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 52101004
    display:
      v: Present (qualifier value)
  text:
    v: Positiv
specimen:
  l: IntegratedBETSlidePR01
  reference:
    v: Specimen/IntegratedBETSlidePR01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

IntegratedPRPercentage
type: Observation
id:
  v: IntegratedPRPercentage
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedPRPercentage Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: PP PR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: 60 % (Details: UCUM code% = '%') specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85325-9
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85325-9
    display:
      v: Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1234803000
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234803000
    display:
      v: Percent of cells with progesterone receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
  coding: http://snomed.info/id/1234806008
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1234806008
    display:
      v: Observation using immunohistochemistry (observable entity)
  text:
    v: PP PR
subject:
  l: Patient4
  reference:
    v: Patient/Patient4
effective: DateTime
  v: 2025-02-10
performer:
  l: PathologistPractitioner
  reference:
    v: Practitioner/PathologistPractitioner
value: Quantity
  value:
    v: 60
  unit:
    v: %
  system:
    v: http://unitsofmeasure.org
    l: unitsofmeasure.org
  code:
    v: %
specimen:
  l: IntegratedBETSlidePR01
  reference:
    v: Specimen/IntegratedBETSlidePR01
derived from:
  l: IntegratedQRBreastResection
  reference:
    v: QuestionnaireResponse/IntegratedQRBreastResection
component:
  code:
    coding: https://loinc.org/rdf/48018-6
      system:
        v: http://loinc.org
        l: loinc.org
      code:
        v: 48018-6
      display:
        v: Gene studied [ID]
  value: CodeableConcept
    coding:
      system:
        v: http://www.genenames.org/geneId
        l: geneId
      code:
        v: HGNC:8910
      display:
        v: PGR

IntegratedPRIntensity
type: Observation
id:
  v: IntegratedPRIntensity
meta:
  profile:
    v: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0
    l: https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding
text:
  status:
    v: generated
  div:
    v: Generated Narrative: Observation IntegratedPRIntensity Profile: MII PR Patho Finding version: 2026.0.0 basedOn: ServiceRequest Pathology synoptic report status: Final category: Laboratory, Pathology report final diagnosis Narrative code: Färbeintensität PR subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105) effective: 2025-02-10 performer: Practitioner Elisabeth Hoffmann value: Mäßig specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen) derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)' Components - Code Value[x] * Gene studied [ID] PGR
based on:
  l: IntegratedReportRequest
  reference:
    v: ServiceRequest/IntegratedReportRequest
status:
  v: final
category:
  coding:
    system:
      v: http://terminology.hl7.org/CodeSystem/observation-category
      l: observation-category
    code:
      v: laboratory
category:
  coding: https://loinc.org/rdf/22637-3
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 22637-3
code:
  coding: https://loinc.org/rdf/85331-7
    system:
      v: http://loinc.org
      l: loinc.org
    code:
      v: 85331-7
    display:
      v: Progesterone receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain
  coding: http://snomed.info/id/1237278006
    system:
      v: http://snomed.info/sct
      l: sct
    code:
      v: 1237278006

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 2

v: °C

v: Cel

v: 8

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

v: 20

v: °C

v: Cel

v: 25

v: °C

v: Cel

l: IntegratedLymphNodeLaterality
reference:
  v: Observation/IntegratedLymphNodeLaterality

l: IntegratedNonSLNExamined
reference:
  v: Observation/IntegratedNonSLNExamined

l: IntegratedNonSLNPositive
reference:
  v: Observation/IntegratedNonSLNPositive

l: IntegratedSLNExamined
reference:
  v: Observation/IntegratedSLNExamined

l: IntegratedSLNPositive
reference:
  v: Observation/IntegratedSLNPositive

l: IntegratedTotalExamined
reference:
  v: Observation/IntegratedTotalExamined

l: IntegratedTotalPositive
reference:
  v: Observation/IntegratedTotalPositive

l: IntegratedMacroMetCount
reference:
  v: Observation/IntegratedMacroMetCount

l: IntegratedMicroMetCount
reference:
  v: Observation/IntegratedMicroMetCount

l: IntegratedITCCount
reference:
  v: Observation/IntegratedITCCount

l: IntegratedLargestMetSize
reference:
  v: Observation/IntegratedLargestMetSize

l: IntegratedExtranodalExtension
reference:
  v: Observation/IntegratedExtranodalExtension

l: IntegratedPN
reference:
  v: Observation/IntegratedPN

l: IntegratedSLNComment
reference:
  v: Observation/IntegratedSLNComment

l: IntegratedQRBreastResection
reference:
  v: QuestionnaireResponse/IntegratedQRBreastResection

l: IntegratedQRLymphNode
reference:
  v: QuestionnaireResponse/IntegratedQRLymphNode