@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://breastcancerspec.org/DiagnosticReport/IntegratedReport> a fhir:DiagnosticReport ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "IntegratedReport"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report|2026.0.0"^^xsd:anyURI ;
       fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report?version=2026.0.0>
     ] )
  ] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport IntegratedReport</b></p><a name=\"IntegratedReport\"> </a><a name=\"hcIntegratedReport\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report\">MII PR Patho Report</a> version: 2026.0.0</p></div><h2><span title=\"Codes:{http://loinc.org 60568-3}\">Pathology Synoptic report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 SP}\">Surgical Pathology</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)</td></tr><tr><td>When For</td><td>2025-02-10 14:00:00+0100</td></tr><tr><td>Reported</td><td>2025-02-10 17:00:00+0100</td></tr><tr><td>Performer</td><td> <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Elisabeth Hoffmann </a></td></tr><tr><td>Identifier</td><td> Accession ID/E_25_300</td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>When For</b></td></tr><tr><td><a href=\"Observation-IntegratedMacroscopicGrouper.html\"><span title=\"Codes:{http://loinc.org 22634-0}\">Pathology report gross observation Narrative</span></a></td><td/><td>Final</td><td>2025-02-06 08:30:00+0100</td></tr><tr><td><a href=\"Observation-IntegratedDiagnosticConclusionGrouper.html\"><span title=\"Codes:{http://loinc.org 22637-3}\">Pathology report final diagnosis Narrative</span></a></td><td/><td>Final</td><td>2025-02-10</td></tr></table><p>Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c pN1mi(sn), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%. SLN 1/2 befallen (Mikrometastase 1,2 mm in SLN #1), keine extranodale Infiltration.</p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ;
           fhir:l <http://terminology.hl7.org/CodeSystem/v2-0203>
         ] ;
         fhir:code [ fhir:v "ACSN" ] ;
         fhir:display [ fhir:v "Accession ID" ]
       ] )
     ] ;
     fhir:system [
       fhir:v "https://pathologie.example-hospital.de/fhir/fn/befundbericht"^^xsd:anyURI ;
       fhir:l <https://pathologie.example-hospital.de/fhir/fn/befundbericht>
     ] ;
     fhir:value [ fhir:v "E_25_300" ]
  ] ) ; # 
  fhir:basedOn ( [
     fhir:l <http://breastcancerspec.org/ServiceRequest/IntegratedReportRequest> ;
     fhir:reference [ fhir:v "ServiceRequest/IntegratedReportRequest" ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
       ] ;
       fhir:code [ fhir:v "SP" ] ;
       fhir:display [ fhir:v "Surgical Pathology" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       a loinc:60568-3 ;
       fhir:system [
         fhir:v "http://loinc.org"^^xsd:anyURI ;
         fhir:l <http://loinc.org>
       ] ;
       fhir:code [ fhir:v "60568-3" ] ;
       fhir:display [ fhir:v "Pathology Synoptic report" ]
     ] )
  ] ; # 
  fhir:subject [
     fhir:l <http://breastcancerspec.org/Patient/Patient4> ;
     fhir:reference [ fhir:v "Patient/Patient4" ]
  ] ; # 
  fhir:effective [
     a fhir:DateTime ;
     fhir:v "2025-02-10T14:00:00+01:00"^^xsd:dateTime
  ] ; # 
  fhir:issued [ fhir:v "2025-02-10T17:00:00+01:00"^^xsd:dateTime] ; # 
  fhir:performer ( [
     fhir:l <http://breastcancerspec.org/Practitioner/PathologistPractitioner> ;
     fhir:reference [ fhir:v "Practitioner/PathologistPractitioner" ]
  ] ) ; # 
  fhir:specimen ( [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenPart> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenPart" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock02> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock02" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock03> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock03" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock04> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock04" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock05> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock05" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSpecimenBlock06> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSpecimenBlock06" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideHE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideHE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideHE02> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideHE02" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideER01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideER01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlidePR01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlidePR01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideHER2IHC01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideHER2IHC01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideKi67-01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideKi67-01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideCK18-01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideCK18-01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlidep40-01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlidep40-01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideECad-01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideECad-01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideBlock02-HE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideBlock02-HE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideBlock02-HE02> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideBlock02-HE02" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Superior-HE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideRR-Superior-HE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Inferior-HE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideRR-Inferior-HE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Medial-HE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideRR-Medial-HE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedBETSlideRR-Lateral-HE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedBETSlideRR-Lateral-HE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSpecimenPart> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSpecimenPart" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSpecimenBlock01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSpecimenBlock01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSpecimenBlock02> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSpecimenBlock02" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSlideHE01> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSlideHE01" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSlideHE02> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSlideHE02" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSlideHE03> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSlideHE03" ]
  ] [
     fhir:l <http://breastcancerspec.org/Specimen/IntegratedSLNSlideHE04> ;
     fhir:reference [ fhir:v "Specimen/IntegratedSLNSlideHE04" ]
  ] ) ; # 
  fhir:result ( [
     fhir:l <http://breastcancerspec.org/Observation/IntegratedMacroscopicGrouper> ;
     fhir:reference [ fhir:v "Observation/IntegratedMacroscopicGrouper" ]
  ] [
     fhir:l <http://breastcancerspec.org/Observation/IntegratedDiagnosticConclusionGrouper> ;
     fhir:reference [ fhir:v "Observation/IntegratedDiagnosticConclusionGrouper" ]
  ] ) ; # 
  fhir:conclusion [ fhir:v "Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c pN1mi(sn), Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%. SLN 1/2 befallen (Mikrometastase 1,2 mm in SLN #1), keine extranodale Infiltration."] . # 

# -------------------------------------------------------------------------------------