@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://breastcancerspec.org/Observation/BreastResectionHER2IHC> a fhir:Observation ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "BreastResectionHER2IHC"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0"^^xsd:anyURI ;
       fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding?version=2026.0.0>
     ] )
  ] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation BreastResectionHER2IHC</b></p><a name=\"BreastResectionHER2IHC\"> </a><a name=\"hcBreastResectionHER2IHC\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding\">MII PR Patho Finding</a> version: 2026.0.0</p></div><p><b>basedOn</b>: <a href=\"ServiceRequest-BreastResectionReportRequest.html\">ServiceRequest Pathology synoptic report</a></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://loinc.org 22637-3}\">Pathology report final diagnosis Narrative</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 85319-2}, {http://snomed.info/sct 3550001000004108}, {http://snomed.info/sct 1234806008}\">Her2 Score</span></p><p><b>subject</b>: <a href=\"Patient-Patient4.html\">Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)</a></p><p><b>effective</b>: 2025-02-10</p><p><b>performer</b>: <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Elisabeth Hoffmann </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA11841-6}\">1+</span></p><p><b>specimen</b>: <a href=\"Specimen-BreastResectionSpecimenSlideHER2IHC01.html\">Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)</a></p><p><b>derivedFrom</b>: <a href=\"QuestionnaireResponse-QuestionnaireResponseBreastResection.html\">Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '-&gt;Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org/geneId HGNC:3430}\">ERBB2</span></td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:basedOn ( [
     fhir:l <http://breastcancerspec.org/ServiceRequest/BreastResectionReportRequest> ;
     fhir:reference [ fhir:v "ServiceRequest/BreastResectionReportRequest" ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
       ] ;
       fhir:code [ fhir:v "laboratory" ]
     ] )
  ] [
     fhir:coding ( [
       a loinc:22637-3 ;
       fhir:system [
         fhir:v "http://loinc.org"^^xsd:anyURI ;
         fhir:l <http://loinc.org>
       ] ;
       fhir:code [ fhir:v "22637-3" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       a loinc:85319-2 ;
       fhir:system [
         fhir:v "http://loinc.org"^^xsd:anyURI ;
         fhir:l <http://loinc.org>
       ] ;
       fhir:code [ fhir:v "85319-2" ] ;
       fhir:display [ fhir:v "HER2 [Presence] in Breast cancer specimen by Immune stain" ]
     ] [
       a sct:3550001000004108 ;
       fhir:system [
         fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
         fhir:l <http://snomed.info/sct>
       ] ;
       fhir:code [ fhir:v "3550001000004108" ] ;
       fhir:display [ fhir:v "Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by immunohistochemistry (observable entity)" ]
     ] [
       a sct:1234806008 ;
       fhir:system [
         fhir:v "http://snomed.info/sct"^^xsd:anyURI ;
         fhir:l <http://snomed.info/sct>
       ] ;
       fhir:code [ fhir:v "1234806008" ] ;
       fhir:display [ fhir:v "Observation using immunohistochemistry (observable entity)" ]
     ] ) ;
     fhir:text [ fhir:v "Her2 Score" ]
  ] ; # 
  fhir:subject [
     fhir:l <http://breastcancerspec.org/Patient/Patient4> ;
     fhir:reference [ fhir:v "Patient/Patient4" ]
  ] ; # 
  fhir:effective [
     a fhir:DateTime ;
     fhir:v "2025-02-10"^^xsd:date
  ] ; # 
  fhir:performer ( [
     fhir:l <http://breastcancerspec.org/Practitioner/PathologistPractitioner> ;
     fhir:reference [ fhir:v "Practitioner/PathologistPractitioner" ]
  ] ) ; # 
  fhir:value [
     a fhir:CodeableConcept ;
     fhir:coding ( [
       a loinc:LA11841-6 ;
       fhir:system [
         fhir:v "http://loinc.org"^^xsd:anyURI ;
         fhir:l <http://loinc.org>
       ] ;
       fhir:code [ fhir:v "LA11841-6" ] ;
       fhir:display [ fhir:v "1+" ]
     ] ) ;
     fhir:text [ fhir:v "1+" ]
  ] ; # 
  fhir:specimen [
     fhir:l <http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHER2IHC01> ;
     fhir:reference [ fhir:v "Specimen/BreastResectionSpecimenSlideHER2IHC01" ]
  ] ; # 
  fhir:derivedFrom ( [
     fhir:l <http://breastcancerspec.org/QuestionnaireResponse/QuestionnaireResponseBreastResection> ;
     fhir:reference [ fhir:v "QuestionnaireResponse/QuestionnaireResponseBreastResection" ]
  ] ) ; # 
  fhir:component ( [
     fhir:code [
       fhir:coding ( [
         a loinc:48018-6 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "48018-6" ] ;
         fhir:display [ fhir:v "Gene studied [ID]" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://www.genenames.org/geneId"^^xsd:anyURI ;
           fhir:l <http://www.genenames.org/geneId>
         ] ;
         fhir:code [ fhir:v "HGNC:3430" ] ;
         fhir:display [ fhir:v "ERBB2" ]
       ] )
     ]
  ] ) . # 

# -------------------------------------------------------------------------------------