{
  "resourceType" : "Observation",
  "id" : "IntegratedERIntensity",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0"]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation IntegratedERIntensity</b></p><a name=\"IntegratedERIntensity\"> </a><a name=\"hcIntegratedERIntensity\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding\">MII PR Patho Finding</a> version: 2026.0.0</p></div><p><b>basedOn</b>: <a href=\"ServiceRequest-IntegratedReportRequest.html\">ServiceRequest Pathology synoptic report</a></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://loinc.org 22637-3}\">Pathology report final diagnosis Narrative</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 85310-1}, {http://snomed.info/sct 1236874005}, {http://snomed.info/sct 1234806008}\">Färbeintensität ER</span></p><p><b>subject</b>: <a href=\"Patient-Patient4.html\">Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)</a></p><p><b>effective</b>: 2025-02-10</p><p><b>performer</b>: <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Elisabeth Hoffmann </a></p><p><b>value</b>: <span title=\"Codes:{http://snomed.info/sct 24484000}\">Stark</span></p><p><b>specimen</b>: <a href=\"Specimen-IntegratedBETSlideER01.html\">Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen)</a></p><p><b>derivedFrom</b>: <a href=\"QuestionnaireResponse-IntegratedQRBreastResection.html\">Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '-&gt;Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org/geneId HGNC:3467}\">ESR1</span></td></tr></table></div>"
  },
  "basedOn" : [{
    "reference" : "ServiceRequest/IntegratedReportRequest"
  }],
  "status" : "final",
  "category" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
      "code" : "laboratory"
    }]
  },
  {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "22637-3"
    }]
  }],
  "code" : {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "85310-1",
      "display" : "Estrogen receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain"
    },
    {
      "system" : "http://snomed.info/sct",
      "code" : "1236874005",
      "display" : "Intensity of stain of estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)"
    },
    {
      "system" : "http://snomed.info/sct",
      "code" : "1234806008",
      "display" : "Observation using immunohistochemistry (observable entity)"
    }],
    "text" : "Färbeintensität ER"
  },
  "subject" : {
    "reference" : "Patient/Patient4"
  },
  "effectiveDateTime" : "2025-02-10",
  "performer" : [{
    "reference" : "Practitioner/PathologistPractitioner"
  }],
  "valueCodeableConcept" : {
    "coding" : [{
      "system" : "http://snomed.info/sct",
      "code" : "24484000",
      "display" : "Severe (severity modifier) (qualifier value)"
    }],
    "text" : "Stark"
  },
  "specimen" : {
    "reference" : "Specimen/IntegratedBETSlideER01"
  },
  "derivedFrom" : [{
    "reference" : "QuestionnaireResponse/IntegratedQRBreastResection"
  }],
  "component" : [{
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "48018-6",
        "display" : "Gene studied [ID]"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "http://www.genenames.org/geneId",
        "code" : "HGNC:3467",
        "display" : "ESR1"
      }]
    }
  }]
}