<?xml version="1.0" encoding="UTF-8"?>

<Observation xmlns="http://hl7.org/fhir">
  <id value="IntegratedERIntensity"/>
  <meta>
    <profile value="https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding|2026.0.0"/>
  </meta>
  <text>
    <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Observation IntegratedERIntensity</b></p><a name="IntegratedERIntensity"> </a><a name="hcIntegratedERIntensity"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-finding">MII PR Patho Finding</a> version: 2026.0.0</p></div><p><b>basedOn</b>: <a href="ServiceRequest-IntegratedReportRequest.html">ServiceRequest Pathology synoptic report</a></p><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://loinc.org 22637-3}">Pathology report final diagnosis Narrative</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 85310-1}, {http://snomed.info/sct 1236874005}, {http://snomed.info/sct 1234806008}">Färbeintensität ER</span></p><p><b>subject</b>: <a href="Patient-Patient4.html">Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)</a></p><p><b>effective</b>: 2025-02-10</p><p><b>performer</b>: <a href="Practitioner-PathologistPractitioner.html">Practitioner Elisabeth Hoffmann </a></p><p><b>value</b>: <span title="Codes:{http://snomed.info/sct 24484000}">Stark</span></p><p><b>specimen</b>: <a href="Specimen-IntegratedBETSlideER01.html">Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_300; status = available; type = Tissue section (specimen)</a></p><p><b>derivedFrom</b>: <a href="QuestionnaireResponse-IntegratedQRBreastResection.html">Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP_Mamma_GH' about '-&gt;Sabine Becker  Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org/geneId HGNC:3467}">ESR1</span></td></tr></table></div>
  </text>
  <basedOn>
    <reference value="ServiceRequest/IntegratedReportRequest"/>
  </basedOn>
  <status value="final"/>
  <category>
    <coding>
      <system value="http://terminology.hl7.org/CodeSystem/observation-category"/>
      <code value="laboratory"/>
    </coding>
  </category>
  <category>
    <coding>
      <system value="http://loinc.org"/>
      <code value="22637-3"/>
    </coding>
  </category>
  <code>
    <coding>
      <system value="http://loinc.org"/>
      <code value="85310-1"/>
      <display value="Estrogen receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain"/>
    </coding>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="1236874005"/>
      <display value="Intensity of stain of estrogen receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)"/>
    </coding>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="1234806008"/>
      <display value="Observation using immunohistochemistry (observable entity)"/>
    </coding>
    <text value="Färbeintensität ER"/>
  </code>
  <subject>
    <reference value="Patient/Patient4"/>
  </subject>
  <effectiveDateTime value="2025-02-10"/>
  <performer>
    <reference value="Practitioner/PathologistPractitioner"/>
  </performer>
  <valueCodeableConcept>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="24484000"/>
      <display value="Severe (severity modifier) (qualifier value)"/>
    </coding>
    <text value="Stark"/>
  </valueCodeableConcept>
  <specimen>
    <reference value="Specimen/IntegratedBETSlideER01"/>
  </specimen>
  <derivedFrom>
    <reference value="QuestionnaireResponse/IntegratedQRBreastResection"/>
  </derivedFrom>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="48018-6"/>
        <display value="Gene studied [ID]"/>
      </coding>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="http://www.genenames.org/geneId"/>
        <code value="HGNC:3467"/>
        <display value="ESR1"/>
      </coding>
    </valueCodeableConcept>
  </component>
</Observation>