{
  "resourceType" : "Bundle",
  "id" : "RadicalProstatectomyDocument",
  "identifier" : {
    "system" : "https://pathologie.example-hospital.de/fhir/fn/befundbericht",
    "value" : "E_24_002"
  },
  "type" : "document",
  "timestamp" : "2024-03-21T08:00:00+01:00",
  "entry" : [{
    "fullUrl" : "http://prostatecancerspec.org/Composition/RadicalProstatectomyComposition",
    "resource" : {
      "resourceType" : "Composition",
      "id" : "RadicalProstatectomyComposition",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Composition_RadicalProstatectomyComposition\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Composition RadicalProstatectomyComposition</b></p><a name=\"RadicalProstatectomyComposition\"> </a><a name=\"hcRadicalProstatectomyComposition\"> </a><p><b>identifier</b>: Accession ID/PATH-COMP-2024-002</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{http://loinc.org 11526-1}, {http://ihe-d.de/CodeSystems/IHEXDStypeCode PATH}\">Pathology study</span></p><p><b>encounter</b>: <a href=\"Encounter-RadicalProstatectomyEncounter.html\">Encounter: identifier = http://example.hospital.de/encounters#E_24_002; status = finished; class = IMP (IMP)</a></p><p><b>date</b>: 2024-03-21 08:00:00+0100</p><p><b>author</b>: <a href=\"Organization-PathologyLabOrganization.html\">Pathologisches Institut</a></p><p><b>title</b>: Histopathologischer Befundbericht - Prostatektomie</p><h3>Attesters</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Mode</b></td><td><b>Party</b></td></tr><tr><td style=\"display: none\">*</td><td>Legal</td><td><a href=\"Organization-PathologyLabOrganization.html\">Organization Pathologielabor</a></td></tr></table><p><b>custodian</b>: <a href=\"Organization-PathologyLabOrganization.html\">Organization Pathologielabor</a></p><h3>Events</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Detail</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v3-ActCode PATREPE}\">pathology report entry task</span></td><td><a href=\"ServiceRequest-RadicalProstatectomyReportRequest.html\">ServiceRequest Pathology synoptic report</a></td></tr></table></div>"
      },
      "identifier" : {
        "type" : {
          "coding" : [{
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }]
        },
        "system" : "http://example.hospital.de/pathology-reports",
        "value" : "PATH-COMP-2024-002"
      },
      "status" : "final",
      "type" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "11526-1",
          "display" : "Pathology study"
        },
        {
          "system" : "http://ihe-d.de/CodeSystems/IHEXDStypeCode",
          "code" : "PATH"
        }]
      },
      "subject" : {
        "reference" : "Patient/Patient1",
        "display" : "Hans Mueller, geb. 15.08.1955 (PAT-2024-001)"
      },
      "encounter" : {
        "reference" : "Encounter/RadicalProstatectomyEncounter"
      },
      "date" : "2024-03-21T08:00:00+01:00",
      "author" : [{
        "reference" : "Organization/PathologyLabOrganization",
        "display" : "Pathologisches Institut"
      }],
      "title" : "Histopathologischer Befundbericht - Prostatektomie",
      "attester" : [{
        "mode" : "legal",
        "party" : {
          "reference" : "Organization/PathologyLabOrganization"
        }
      }],
      "custodian" : {
        "reference" : "Organization/PathologyLabOrganization"
      },
      "event" : [{
        "code" : [{
          "coding" : [{
            "system" : "http://terminology.hl7.org/CodeSystem/v3-ActCode",
            "code" : "PATREPE"
          }]
        }],
        "detail" : [{
          "reference" : "ServiceRequest/RadicalProstatectomyReportRequest"
        }]
      }],
      "section" : [{
        "title" : "Pathologiebefundbericht",
        "code" : {
          "coding" : [{
            "system" : "http://loinc.org",
            "code" : "60567-5",
            "display" : "Comprehensive pathology report panel"
          }]
        },
        "text" : {
          "status" : "additional",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><h3>Klinische Angaben</h3><p>Z.n. Prostata-Stanzbiopsie mit Nachweis eines Prostatakarzinoms (höchster Gleason 4+5=9, ISUP-Gradgruppe 5). Radikale Prostatektomie mit pelviner Lymphadenektomie.</p><h3>Makroskopie</h3><p>Prostatektomiepräparat 55 g, Maße 4,5 × 4,0 × 3,5 cm. Samenbläschen beidseits 2,5 cm. Lymphknoten bilateral vorhanden.</p><table border=\"1\" cellpadding=\"4\" cellspacing=\"0\"><tbody><tr><td>Präparat</td><td>Radikale Prostatektomie mit Samenblasen und pelvinen Lymphknoten</td></tr><tr><td>Gewicht</td><td>55 g</td></tr><tr><td>Maße (B × H × T)</td><td>4,5 × 4,0 × 3,5 cm</td></tr><tr><td>Samenblasen</td><td>Vorhanden, beidseits 2,5 cm</td></tr><tr><td>Lymphknoten</td><td>Bilateral vorhanden</td></tr></tbody></table><h3>Mikroskopie</h3><p>Azinäres Adenokarzinom der Prostata mit gemischten, überwiegend klein- bis mitteltubulären, mäßig irregulären Drüsen sowie einem geringeren Anteil an kribriformen Wachstumsmustern. Tumorgewebe in beiden Seitenlappen nachweisbar. Kein kapselüberschreitendes Wachstum. Samenblasen und Lymphknoten tumorgewebsfrei.</p><h3>Diagnostische Schlussfolgerung</h3><p>Gleason-Score 3+4=7, ISUP-Gradgruppe 2 (WHO 2016). Maximaler Tumordurchmesser 18 mm, 25% des Prostatagewebes tumorbefallen. Anteil Gleasonmuster 4/5: 30%. Kein intraduktales Karzinom, kein invasives kribriformes Karzinom. Keine extraprostatische Ausbreitung, keine Samenblaseninfiltration, keine lymphovaskuläre Invasion, keine perineurale Infiltration, keine Blasenhalsinvasion. Absetzungsränder tumorfrei (R0). 12 Lymphknoten untersucht, 0 positiv. Staging: pT2 pN0.</p><table border=\"1\" cellpadding=\"4\" cellspacing=\"0\"><tbody><tr><td>Histologischer Typ</td><td>Azinäres Adenokarzinom (8140/3)</td></tr><tr><td>Gleason-Score</td><td>3+4=7</td></tr><tr><td>ISUP-Gradgruppe</td><td>2 (WHO 2016)</td></tr><tr><td>Maximaler Tumordurchmesser</td><td>18 mm</td></tr><tr><td>Tumoranteil</td><td>25%</td></tr><tr><td>Anteil Gleason 4/5</td><td>30%</td></tr><tr><td>Intraduktales Karzinom</td><td>Nicht nachgewiesen</td></tr><tr><td>Invasives kribriformes Karzinom</td><td>Nicht nachgewiesen</td></tr><tr><td>Extraprostatische Ausbreitung</td><td>Nicht nachgewiesen</td></tr><tr><td>Samenblaseninfiltration</td><td>Nicht nachgewiesen</td></tr><tr><td>Lymphovaskuläre Invasion</td><td>Nicht nachgewiesen</td></tr><tr><td>Perineurale Infiltration</td><td>Nicht nachgewiesen</td></tr><tr><td>Blasenhalsinvasion</td><td>Nicht nachgewiesen</td></tr><tr><td>Absetzungsränder</td><td>Tumorfrei (R0)</td></tr><tr><td>Lymphknoten untersucht</td><td>12</td></tr><tr><td>Lymphknoten positiv</td><td>0</td></tr><tr><td>pT-Stadium</td><td>pT2</td></tr><tr><td>pN-Stadium</td><td>pN0</td></tr></tbody></table><p><b>Diagnose:</b> Azinäres Adenokarzinom der Prostata (ICD-O 8140/3)</p></div>"
        },
        "entry" : [{
          "reference" : "DiagnosticReport/RadicalProstatectomyReport"
        }]
      }]
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/Patient/Patient1",
    "resource" : {
      "resourceType" : "Patient",
      "id" : "Patient1",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_Patient1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient Patient1</b></p><a name=\"Patient1\"> </a><a name=\"hcPatient1\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</p><hr/></div>"
      },
      "identifier" : [{
        "system" : "http://example.hospital.de/patient-ids",
        "value" : "PAT-2024-001"
      }],
      "name" : [{
        "family" : "Mueller",
        "given" : ["Hans"]
      }],
      "gender" : "male",
      "birthDate" : "1955-08-15"
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/Organization/PathologyLabOrganization",
    "resource" : {
      "resourceType" : "Organization",
      "id" : "PathologyLabOrganization",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_PathologyLabOrganization\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Organization PathologyLabOrganization</b></p><a name=\"PathologyLabOrganization\"> </a><a name=\"hcPathologyLabOrganization\"> </a><p><b>identifier</b>: <code>http://example.hospital.de/organization-ids</code>/ORG-PATH-001</p><p><b>name</b>: Pathologielabor</p></div>"
      },
      "identifier" : [{
        "system" : "http://example.hospital.de/organization-ids",
        "value" : "ORG-PATH-001"
      }],
      "name" : "Pathologielabor"
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/DiagnosticReport/RadicalProstatectomyReport",
    "resource" : {
      "resourceType" : "DiagnosticReport",
      "id" : "RadicalProstatectomyReport",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report|2026.0.0"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_RadicalProstatectomyReport\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport RadicalProstatectomyReport</b></p><a name=\"RadicalProstatectomyReport\"> </a><a name=\"hcRadicalProstatectomyReport\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-report\">MII PR Patho Report</a> version: 2026.0.0</p></div><h2><span title=\"Codes:{http://loinc.org 60568-3}\">Pathology Synoptic report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 SP}\">Surgical Pathology</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</td></tr><tr><td>Relevant Time</td><td>2024-03-20 17:00:00+0100</td></tr><tr><td>Reported</td><td>2024-03-21 08:00:00+0100</td></tr><tr><td>Performer</td><td> <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Maria Schneider </a></td></tr><tr><td>Identifier</td><td> Accession ID/E_24_002</td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Relevant Time</b></td></tr><tr><td><a href=\"Observation-RadicalProstatectomyMacroscopicGrouper.html\"><span title=\"Codes:{http://loinc.org 22634-0}\">Pathology report gross observation Narrative</span></a> (<span title=\"Codes:{http://snomed.info/sct 41216001}\">Prostate</span>)</td><td>Makroskopische Messungen des Prostatektomiepräparats</td><td>Final</td><td>2024-03-16 14:00:00+0100</td></tr><tr><td><a href=\"Observation-RadicalProstatectomyDiagnosticConclusionGrouper.html\"><span title=\"Codes:{http://loinc.org 22637-3}\">Pathology report final diagnosis Narrative</span></a></td><td/><td>Final</td><td>2024-03-20</td></tr></table><p>Adenokarzinom der Prostata, Gleason Score 3+4=7, pT2 pN0 (0/12) R0. Maximaler Tumordurchmesser 18 mm (ca. 25% der Prostata). Keine extrakapsuläre Extension, keine Samenblaseninvasion, alle Resektionsränder tumorfrei.</p></div>"
      },
      "identifier" : [{
        "type" : {
          "coding" : [{
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }]
        },
        "system" : "https://pathologie.example-hospital.de/fhir/fn/befundbericht",
        "value" : "E_24_002"
      }],
      "basedOn" : [{
        "reference" : "ServiceRequest/RadicalProstatectomyReportRequest"
      }],
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
          "code" : "SP",
          "display" : "Surgical Pathology"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "60568-3",
          "display" : "Pathology Synoptic report"
        }]
      },
      "subject" : {
        "reference" : "Patient/Patient1"
      },
      "effectiveDateTime" : "2024-03-20T17:00:00+01:00",
      "issued" : "2024-03-21T08:00:00+01:00",
      "performer" : [{
        "reference" : "Practitioner/PathologistPractitioner"
      }],
      "specimen" : [{
        "reference" : "Specimen/RadicalProstatectomySpecimenPart"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenBlock01"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide01A"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide01B"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenBlock02"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide02A"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide02B"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenBlock03"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide03A"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenSlide03B"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeRight"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeRightBlock"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeRightSlide01"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeRightSlide02"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeLeft"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeLeftBlock"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeLeftSlide01"
      },
      {
        "reference" : "Specimen/RadicalProstatectomySpecimenLymphNodeLeftSlide02"
      }],
      "result" : [{
        "reference" : "Observation/RadicalProstatectomyMacroscopicGrouper"
      },
      {
        "reference" : "Observation/RadicalProstatectomyDiagnosticConclusionGrouper"
      }],
      "conclusion" : "Adenokarzinom der Prostata, Gleason Score 3+4=7, pT2 pN0 (0/12) R0. Maximaler Tumordurchmesser 18 mm (ca. 25% der Prostata). Keine extrakapsuläre Extension, keine Samenblaseninvasion, alle Resektionsränder tumorfrei."
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/Observation/RadicalProstatectomyDiagnosticConclusionGrouper",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "RadicalProstatectomyDiagnosticConclusionGrouper",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper|2026.0.0"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_RadicalProstatectomyDiagnosticConclusionGrouper\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation RadicalProstatectomyDiagnosticConclusionGrouper</b></p><a name=\"RadicalProstatectomyDiagnosticConclusionGrouper\"> </a><a name=\"hcRadicalProstatectomyDiagnosticConclusionGrouper\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-diagnostic-conclusion-grouper\">MII PR Patho Diagnostic Conclusion Grouper</a> version: 2026.0.0</p></div><p><b>basedOn</b>: <a href=\"ServiceRequest-RadicalProstatectomyReportRequest.html\">ServiceRequest Pathology synoptic report</a></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 22637-3}\">Pathology report final diagnosis Narrative</span></p><p><b>subject</b>: <a href=\"Patient-Patient1.html\">Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</a></p><p><b>effective</b>: 2024-03-20</p><p><b>performer</b>: <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Maria Schneider </a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Observation-RadicalProstatectomyHistologicalTypeICDO3.html\">Observation Histology and Behavior ICD-O-3 Cancer</a></li><li><a href=\"Observation-RadicalProstatectomyMorphologyFreeText.html\">Observation Histology type in Cancer specimen Narrative</a></li><li><a href=\"Observation-RadicalProstatectomyICDOVersion.html\">Observation World Health Organization tumor classification (observable entity)</a></li><li><a href=\"Observation-RadicalProstatectomyPrimaryGleasonPattern.html\">Observation Gleason pattern.primary in Prostate tumor</a></li><li><a href=\"Observation-RadicalProstatectomySecondaryGleasonPattern.html\">Observation Gleason pattern.secondary in Prostate tumor</a></li><li><a href=\"Observation-RadicalProstatectomyGleasonScoreTotal.html\">Observation Gleason score in Specimen Qualitative</a></li><li><a href=\"Observation-RadicalProstatectomyPercentageGleason45.html\">Observation Prostate tumor area with Gleason pattern 4+5/Total tumor area [Area Fraction] in Prostate tumor by Microscopy</a></li><li><a href=\"Observation-RadicalProstatectomyGradingGroupISUP.html\">Observation Histologic grade of primary malignant neoplasm of prostate by International Society of Urological Pathology technique (observable entity)</a></li><li><a href=\"Observation-RadicalProstatectomyIntraductalCarcinoma.html\">Observation Non-infiltrating intraductal carcinoma (morphologic abnormality)</a></li><li><a href=\"Observation-RadicalProstatectomyInvasiveCribriformCarcinoma.html\">Observation Cribriform carcinoma</a></li><li><a href=\"Observation-RadicalProstatectomyMaxTumorDiameter.html\">Observation Size.maximum dimension in Tumor</a></li><li><a href=\"Observation-RadicalProstatectomyProstaticTissueInvolved.html\">Observation Tissue involved by tumor in Prostate tumor</a></li><li><a href=\"Observation-RadicalProstatectomyExtraprostaticExtension.html\">Observation Periprostatic fat invasion [Identifier] in Specimen by CAP cancer protocols</a></li><li><a href=\"Observation-RadicalProstatectomySeminalVesicleInvasion.html\">Observation Seminal vesicle invasion [Identifier] in Specimen by CAP cancer protocols</a></li><li><a href=\"Observation-RadicalProstatectomyLymphovascularInvasion.html\">Observation Venous + Lymphatic small vessel invasion in Specimen by CAP cancer protocols</a></li><li><a href=\"Observation-RadicalProstatectomyPerineuralInfiltration.html\">Observation Perineural invasion [Presence] in Cancer specimen</a></li><li><a href=\"Observation-RadicalProstatectomyBladderNeckInvasion.html\">Observation Bladder neck involvement of Prostate tumor</a></li><li><a href=\"Observation-RadicalProstatectomyMarginStatus.html\">Observation Margin involvement [Type] in Prostate tumor</a></li><li><a href=\"Observation-RadicalProstatectomyLymphNodesExamined.html\">Observation Regional lymph nodes examined [#] Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyLymphNodesPositive.html\">Observation Regional lymph nodes positive [#] Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyTNMpT.html\">Observation Primary tumor.pathology Cancer</a></li><li><a href=\"Observation-RadicalProstatectomyTNMpN.html\">Observation Regional lymph nodes.pathology [Class] Cancer</a></li></ul><p><b>derivedFrom</b>: <a href=\"QuestionnaireResponse-QuestionnaireResponseRadicalProstatectomy.html\">Response to Questionnaire 'https://art-decor.org/fhir/Questionnaire/2.16.840.1.113883.3.1937.777.18.27.19--20250115134435' about '-&gt;Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)'</a></p></div>"
      },
      "basedOn" : [{
        "reference" : "ServiceRequest/RadicalProstatectomyReportRequest"
      }],
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "22637-3"
        }]
      },
      "subject" : {
        "reference" : "Patient/Patient1"
      },
      "effectiveDateTime" : "2024-03-20",
      "performer" : [{
        "reference" : "Practitioner/PathologistPractitioner"
      }],
      "hasMember" : [{
        "reference" : "Observation/RadicalProstatectomyHistologicalTypeICDO3"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMorphologyFreeText"
      },
      {
        "reference" : "Observation/RadicalProstatectomyICDOVersion"
      },
      {
        "reference" : "Observation/RadicalProstatectomyPrimaryGleasonPattern"
      },
      {
        "reference" : "Observation/RadicalProstatectomySecondaryGleasonPattern"
      },
      {
        "reference" : "Observation/RadicalProstatectomyGleasonScoreTotal"
      },
      {
        "reference" : "Observation/RadicalProstatectomyPercentageGleason45"
      },
      {
        "reference" : "Observation/RadicalProstatectomyGradingGroupISUP"
      },
      {
        "reference" : "Observation/RadicalProstatectomyIntraductalCarcinoma"
      },
      {
        "reference" : "Observation/RadicalProstatectomyInvasiveCribriformCarcinoma"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMaxTumorDiameter"
      },
      {
        "reference" : "Observation/RadicalProstatectomyProstaticTissueInvolved"
      },
      {
        "reference" : "Observation/RadicalProstatectomyExtraprostaticExtension"
      },
      {
        "reference" : "Observation/RadicalProstatectomySeminalVesicleInvasion"
      },
      {
        "reference" : "Observation/RadicalProstatectomyLymphovascularInvasion"
      },
      {
        "reference" : "Observation/RadicalProstatectomyPerineuralInfiltration"
      },
      {
        "reference" : "Observation/RadicalProstatectomyBladderNeckInvasion"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMarginStatus"
      },
      {
        "reference" : "Observation/RadicalProstatectomyLymphNodesExamined"
      },
      {
        "reference" : "Observation/RadicalProstatectomyLymphNodesPositive"
      },
      {
        "reference" : "Observation/RadicalProstatectomyTNMpT"
      },
      {
        "reference" : "Observation/RadicalProstatectomyTNMpN"
      }],
      "derivedFrom" : [{
        "reference" : "QuestionnaireResponse/QuestionnaireResponseRadicalProstatectomy"
      }]
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/Observation/RadicalProstatectomyMacroscopicGrouper",
    "resource" : {
      "resourceType" : "Observation",
      "id" : "RadicalProstatectomyMacroscopicGrouper",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper|2026.0.0"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_RadicalProstatectomyMacroscopicGrouper\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation RadicalProstatectomyMacroscopicGrouper</b></p><a name=\"RadicalProstatectomyMacroscopicGrouper\"> </a><a name=\"hcRadicalProstatectomyMacroscopicGrouper\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-macroscopic-grouper\">MII PR Patho Macroscopic Grouper</a> version: 2026.0.0</p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 22634-0}\">Pathology report gross observation Narrative</span></p><p><b>subject</b>: <a href=\"Patient-Patient1.html\">Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</a></p><p><b>effective</b>: 2024-03-16 14:00:00+0100</p><p><b>performer</b>: <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Maria Schneider </a></p><p><b>value</b>: Makroskopische Messungen des Prostatektomiepräparats</p><p><b>bodySite</b>: <span title=\"Codes:{http://snomed.info/sct 41216001}\">Prostate</span></p><p><b>hasMember</b>: </p><ul><li><a href=\"Observation-RadicalProstatectomyMacroscopicProstateWeight.html\">Observation Weight of Tissue</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicProstateWidth.html\">Observation Dimension [Length] of Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicProstateHeight.html\">Observation Dimension [Length] of Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicProstateDepth.html\">Observation Dimension [Length] of Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicLymphNodesPresent.html\">Observation Tumor finding</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicLymphNodesLaterality.html\">Observation Anatomic part Laterality</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicSeminalVesiclesPresent.html\">Observation Seminal vesicles [Presence] in Specimen</a></li><li><a href=\"Observation-RadicalProstatectomyMacroscopicSeminalVesicleLength.html\">Observation Dimension [Length] of Specimen</a></li></ul><p><b>derivedFrom</b>: <a href=\"QuestionnaireResponse-QuestionnaireResponseRadicalProstatectomy.html\">Response to Questionnaire 'https://art-decor.org/fhir/Questionnaire/2.16.840.1.113883.3.1937.777.18.27.19--20250115134435' about '-&gt;Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)'</a></p></div>"
      },
      "status" : "final",
      "category" : [{
        "coding" : [{
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "22634-0"
        }]
      },
      "subject" : {
        "reference" : "Patient/Patient1"
      },
      "effectiveDateTime" : "2024-03-16T14:00:00+01:00",
      "performer" : [{
        "reference" : "Practitioner/PathologistPractitioner"
      }],
      "valueString" : "Makroskopische Messungen des Prostatektomiepräparats",
      "bodySite" : {
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "41216001",
          "display" : "Prostate"
        }]
      },
      "hasMember" : [{
        "reference" : "Observation/RadicalProstatectomyMacroscopicProstateWeight"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicProstateWidth"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicProstateHeight"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicProstateDepth"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicLymphNodesPresent"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicLymphNodesLaterality"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicSeminalVesiclesPresent"
      },
      {
        "reference" : "Observation/RadicalProstatectomyMacroscopicSeminalVesicleLength"
      }],
      "derivedFrom" : [{
        "reference" : "QuestionnaireResponse/QuestionnaireResponseRadicalProstatectomy"
      }]
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/Encounter/RadicalProstatectomyEncounter",
    "resource" : {
      "resourceType" : "Encounter",
      "id" : "RadicalProstatectomyEncounter",
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Encounter_RadicalProstatectomyEncounter\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Encounter RadicalProstatectomyEncounter</b></p><a name=\"RadicalProstatectomyEncounter\"> </a><a name=\"hcRadicalProstatectomyEncounter\"> </a><p><b>identifier</b>: <code>http://example.hospital.de/encounters</code>/E_24_002</p><p><b>status</b>: Finished</p><p><b>class</b>: [not stated]: IMP (IMP)</p><p><b>subject</b>: <a href=\"Patient-Patient1.html\">Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</a></p></div>"
      },
      "identifier" : [{
        "system" : "http://example.hospital.de/encounters",
        "value" : "E_24_002"
      }],
      "status" : "finished",
      "class" : {
        "code" : "IMP"
      },
      "subject" : {
        "reference" : "Patient/Patient1"
      }
    }
  },
  {
    "fullUrl" : "http://prostatecancerspec.org/ServiceRequest/RadicalProstatectomyReportRequest",
    "resource" : {
      "resourceType" : "ServiceRequest",
      "id" : "RadicalProstatectomyReportRequest",
      "meta" : {
        "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request|2026.0.0"]
      },
      "text" : {
        "status" : "generated",
        "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ServiceRequest_RadicalProstatectomyReportRequest\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ServiceRequest RadicalProstatectomyReportRequest</b></p><a name=\"RadicalProstatectomyReportRequest\"> </a><a name=\"hcRadicalProstatectomyReportRequest\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"https://simplifier.net/resolve?scope=de.medizininformatikinitiative.kerndatensatz.patho@2026.0.0&amp;canonical=https://www.medizininformatik-initiative.de/fhir/ext/modul-patho/StructureDefinition/mii-pr-patho-service-request\">MII PR Patho Service Request</a> version: 2026.0.0</p></div><p><b>identifier</b>: Placer Identifier/PATH-RPT-2024-002</p><p><b>status</b>: Completed</p><p><b>intent</b>: Order</p><p><b>category</b>: <span title=\"Codes:{http://snomed.info/sct 726007}\">Pathology consultation, comprehensive, records and specimen with report (procedure)</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 60568-3}\">Pathology synoptic report</span></p><p><b>subject</b>: <a href=\"Patient-Patient1.html\">Hans Mueller  Male, DoB: 1955-08-15 ( http://example.hospital.de/patient-ids#PAT-2024-001)</a></p><p><b>encounter</b>: <a href=\"Encounter-RadicalProstatectomyEncounter.html\">Encounter: identifier = http://example.hospital.de/encounters#E_24_002; status = finished; class = IMP (IMP)</a></p><p><b>requester</b>: <a href=\"Practitioner-UrologistPractitioner.html\">Practitioner Andreas Weber </a></p><p><b>performer</b>: <a href=\"Practitioner-PathologistPractitioner.html\">Practitioner Maria Schneider </a></p><p><b>reasonCode</b>: <span title=\"Codes:{http://snomed.info/sct 399068003}\">Malignant tumor of prostate</span></p><p><b>supportingInfo</b>: <a href=\"Condition-RadicalProstatectomyDiagnosisPreOp.html\">Condition Bösartige Neubildung der Prostata</a></p><p><b>specimen</b>: <a href=\"Specimen-RadicalProstatectomySpecimenPart.html\">Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_24_002; status = available; type = Specimen from prostate obtained by radical prostatectomy (specimen)</a></p></div>"
      },
      "identifier" : [{
        "type" : {
          "coding" : [{
            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "PLAC",
            "display" : "Placer Identifier"
          }]
        },
        "system" : "http://example.hospital.de/serviceRequest",
        "value" : "PATH-RPT-2024-002"
      }],
      "status" : "completed",
      "intent" : "order",
      "category" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "726007",
          "display" : "Pathology consultation, comprehensive, records and specimen with report (procedure)"
        }]
      }],
      "code" : {
        "coding" : [{
          "system" : "http://loinc.org",
          "code" : "60568-3",
          "display" : "Pathology synoptic report"
        }]
      },
      "subject" : {
        "reference" : "Patient/Patient1"
      },
      "encounter" : {
        "reference" : "Encounter/RadicalProstatectomyEncounter"
      },
      "requester" : {
        "reference" : "Practitioner/UrologistPractitioner"
      },
      "performer" : [{
        "reference" : "Practitioner/PathologistPractitioner"
      }],
      "reasonCode" : [{
        "coding" : [{
          "system" : "http://snomed.info/sct",
          "code" : "399068003",
          "display" : "Malignant tumor of prostate"
        }]
      }],
      "supportingInfo" : [{
        "reference" : "Condition/RadicalProstatectomyDiagnosisPreOp"
      }],
      "specimen" : [{
        "reference" : "Specimen/RadicalProstatectomySpecimenPart"
      }]
    }
  }]
}