@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <http://loinc.org/rdf#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://prostatecancerspec.org/Composition/CoreNeedleBiopsyComposition> a fhir:Composition ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:Resource.id [ fhir:value "CoreNeedleBiopsyComposition"] ;
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ] ;
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Composition CoreNeedleBiopsyComposition</b></p><a name=\"CoreNeedleBiopsyComposition\"> </a><a name=\"hcCoreNeedleBiopsyComposition\"> </a><p><b>identifier</b>: Accession ID/PATH-COMP-2024-001</p><p><b>status</b>: Final</p><p><b>type</b>: <span title=\"Codes:{http://loinc.org 11526-1}, {http://ihe-d.de/CodeSystems/IHEXDStypeCode PATH}, {http://snomed.info/sct 721967005}\">Pathology study</span></p><p><b>encounter</b>: <a href=\"Encounter-CoreNeedleBiopsyEncounter.html\">Encounter: identifier = http://example.hospital.de/encounters#E_24_001; status = finished; class = IMB (IMB)</a></p><p><b>date</b>: 2024-01-20 15:30:00+0100</p><p><b>author</b>: <a href=\"Organization-PathologyLabOrganization.html\">Pathologisches Institut</a></p><p><b>title</b>: Histopathologischer Befundbericht - Prostatabiopsie</p><h3>Attesters</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Mode</b></td><td><b>Party</b></td></tr><tr><td style=\"display: none\">*</td><td>Legal</td><td><a href=\"Organization-PathologyLabOrganization.html\">Organization Pathologielabor</a></td></tr></table><p><b>custodian</b>: <a href=\"Organization-PathologyLabOrganization.html\">Organization Pathologielabor</a></p><h3>Events</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Detail</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v3-ActCode PATREPE}\">pathology report entry task</span></td><td><a href=\"ServiceRequest-CoreNeedleBiopsyReportRequest.html\">ServiceRequest Prostate Pathology biopsy report</a></td></tr></table></div>"
  ] ;
  fhir:Composition.identifier [
     fhir:Identifier.type [
       fhir:CodeableConcept.coding [
         fhir:index 0 ;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0203" ] ;
         fhir:Coding.code [ fhir:value "ACSN" ] ;
         fhir:Coding.display [ fhir:value "Accession ID" ]
       ]
     ] ;
     fhir:Identifier.system [ fhir:value "http://example.hospital.de/pathology-reports" ] ;
     fhir:Identifier.value [ fhir:value "PATH-COMP-2024-001" ]
  ] ;
  fhir:Composition.status [ fhir:value "final"] ;
  fhir:Composition.type [
     fhir:CodeableConcept.coding [
       fhir:index 0 ;
       a loinc:11526-1 ;
       fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
       fhir:Coding.code [ fhir:value "11526-1" ] ;
       fhir:Coding.display [ fhir:value "Pathology study" ]
     ], [
       fhir:index 1 ;
       fhir:Coding.system [ fhir:value "http://ihe-d.de/CodeSystems/IHEXDStypeCode" ] ;
       fhir:Coding.code [ fhir:value "PATH" ]
     ], [
       fhir:index 2 ;
       a sct:721967005 ;
       fhir:Coding.system [ fhir:value "http://snomed.info/sct" ] ;
       fhir:Coding.code [ fhir:value "721967005" ] ;
       fhir:Coding.display [ fhir:value "Tissue pathology biopsy report" ]
     ]
  ] ;
  fhir:Composition.subject [
     fhir:link <http://prostatecancerspec.org/Patient/Patient1> ;
     fhir:Reference.reference [ fhir:value "Patient/Patient1" ] ;
     fhir:Reference.display [ fhir:value "Hans Mueller, geb. 15.08.1955 (PAT-2024-001)" ]
  ] ;
  fhir:Composition.encounter [
     fhir:link <http://prostatecancerspec.org/Encounter/CoreNeedleBiopsyEncounter> ;
     fhir:Reference.reference [ fhir:value "Encounter/CoreNeedleBiopsyEncounter" ]
  ] ;
  fhir:Composition.date [ fhir:value "2024-01-20T15:30:00+01:00"^^xsd:dateTime] ;
  fhir:Composition.author [
     fhir:index 0 ;
     fhir:link <http://prostatecancerspec.org/Organization/PathologyLabOrganization> ;
     fhir:Reference.reference [ fhir:value "Organization/PathologyLabOrganization" ] ;
     fhir:Reference.display [ fhir:value "Pathologisches Institut" ]
  ] ;
  fhir:Composition.title [ fhir:value "Histopathologischer Befundbericht - Prostatabiopsie"] ;
  fhir:Composition.attester [
     fhir:index 0 ;
     fhir:Composition.attester.mode [ fhir:value "legal" ] ;
     fhir:Composition.attester.party [
       fhir:link <http://prostatecancerspec.org/Organization/PathologyLabOrganization> ;
       fhir:Reference.reference [ fhir:value "Organization/PathologyLabOrganization" ]
     ]
  ] ;
  fhir:Composition.custodian [
     fhir:link <http://prostatecancerspec.org/Organization/PathologyLabOrganization> ;
     fhir:Reference.reference [ fhir:value "Organization/PathologyLabOrganization" ]
  ] ;
  fhir:Composition.event [
     fhir:index 0 ;
     fhir:Composition.event.code [
       fhir:index 0 ;
       fhir:CodeableConcept.coding [
         fhir:index 0 ;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v3-ActCode" ] ;
         fhir:Coding.code [ fhir:value "PATREPE" ]
       ]
     ] ;
     fhir:Composition.event.detail [
       fhir:index 0 ;
       fhir:link <http://prostatecancerspec.org/ServiceRequest/CoreNeedleBiopsyReportRequest> ;
       fhir:Reference.reference [ fhir:value "ServiceRequest/CoreNeedleBiopsyReportRequest" ]
     ]
  ] ;
  fhir:Composition.section [
     fhir:index 0 ;
     fhir:Composition.section.title [ fhir:value "Pathologiebefundbericht" ] ;
     fhir:Composition.section.code [
       fhir:CodeableConcept.coding [
         fhir:index 0 ;
         a loinc:60567-5 ;
         fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
         fhir:Coding.code [ fhir:value "60567-5" ] ;
         fhir:Coding.display [ fhir:value "Comprehensive pathology report panel" ]
       ]
     ] ;
     fhir:Composition.section.text [
       fhir:Narrative.status [ fhir:value "additional" ] ;
       fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><h3>Klinische Angaben</h3><p>Erhöhter PSA-Wert (8,5 ng/ml). V.a. Prostatakarzinom. Bitte histologische Abklärung.</p><h3>Makroskopie</h3><p>Makroskopische Messungen für alle 12 Prostatastanzen: Längen 1,3–1,9 cm, je 1 Zylinder pro Specimen. Stanzen 01–06 aus rechter Prostataregion (lateral basal/mid/apikal, medial basal/mid/apikal), Stanzen 07–12 aus linker Prostataregion (lateral basal/mid/apikal, medial basal/mid/apikal).</p><table border=\"1\" cellpadding=\"4\" cellspacing=\"0\"><thead><tr><th>Stanze</th><th>Lokalisation</th><th>Stanzenlänge (cm)</th><th>Zylinderanzahl im Gefäß</th></tr></thead><tbody><tr><td>01</td><td>Rechts lateral basal</td><td>1.8</td><td>1</td></tr><tr><td>02</td><td>Rechts lateral mid</td><td>1.6</td><td>1</td></tr><tr><td>03</td><td>Rechts lateral apikal</td><td>1.5</td><td>1</td></tr><tr><td>04</td><td>Rechts medial basal</td><td>1.9</td><td>1</td></tr><tr><td>05</td><td>Rechts medial mid</td><td>1.4</td><td>1</td></tr><tr><td>06</td><td>Rechts medial apikal</td><td>1.7</td><td>1</td></tr><tr><td>07</td><td>Links lateral basal</td><td>1.6</td><td>1</td></tr><tr><td>08</td><td>Links lateral mid</td><td>1.5</td><td>1</td></tr><tr><td>09</td><td>Links lateral apikal</td><td>1.8</td><td>1</td></tr><tr><td>10</td><td>Links medial basal</td><td>1.3</td><td>1</td></tr><tr><td>11</td><td>Links medial mid</td><td>1.7</td><td>1</td></tr><tr><td>12</td><td>Links medial apikal</td><td>1.4</td><td>1</td></tr></tbody></table><h3>Mikroskopie</h3><p>Adenokarzinom in 7 von 12 Stanzen nachgewiesen (01, 02, 04, 06, 07, 09, 11). Gleason-Scores: Stanze 01 (3+4=7), Stanze 02 (4+3=7), Stanze 04 (4+4=8), Stanze 06 (3+3=6), Stanze 07 (4+5=9), Stanze 09 (3+4=7), Stanze 11 (3+4=7). Höchster Gleason-Score 4+5=9, ISUP-Gradgruppe 5. Benigne Befunde in Stanzen 03, 05, 08, 10, 12.</p><table border=\"1\" cellpadding=\"4\" cellspacing=\"0\"><thead><tr><th>Stanze</th><th>Befund</th><th>Gleason-Score</th><th>Tumoranteil</th></tr></thead><tbody><tr><td>01</td><td>Adenokarzinom</td><td>3+4=7</td><td>40%</td></tr><tr><td>02</td><td>Adenokarzinom</td><td>4+3=7</td><td>60%</td></tr><tr><td>03</td><td>Benigne</td><td>-</td><td>-</td></tr><tr><td>04</td><td>Adenokarzinom</td><td>4+4=8</td><td>80%</td></tr><tr><td>05</td><td>Benigne</td><td>-</td><td>-</td></tr><tr><td>06</td><td>Adenokarzinom</td><td>3+3=6</td><td>20%</td></tr><tr><td>07</td><td>Adenokarzinom</td><td>4+5=9</td><td>95%</td></tr><tr><td>08</td><td>Benigne</td><td>-</td><td>-</td></tr><tr><td>09</td><td>Adenokarzinom</td><td>3+4=7</td><td>35%</td></tr><tr><td>10</td><td>Benigne</td><td>-</td><td>-</td></tr><tr><td>11</td><td>Adenokarzinom</td><td>3+4=7</td><td>25%</td></tr><tr><td>12</td><td>Benigne</td><td>-</td><td>-</td></tr></tbody></table><h3>Diagnostische Schlussfolgerung</h3><p>7 von 12 Stanzen tumorbefallen (4 rechts: 01, 02, 04, 06; 3 links: 07, 09, 11). Prozentualer Tumoranteil 51%, Tumorlänge gesamt 52,7 mm. Perineurale Infiltration und Infiltration des periprostatischen Fettgewebes apikal nachgewiesen. Samenblaseninfiltration, lymphovaskuläre Invasion, intraduktales Karzinom, ASAP, High-grade-PIN und granulomatöse Prostatitis nicht nachgewiesen.</p><table border=\"1\" cellpadding=\"4\" cellspacing=\"0\"><tbody><tr><td>Histologischer Typ</td><td>Azinäres Adenokarzinom (8140/3)</td></tr><tr><td>Gleason-Score</td><td>4+5=9 (höchster Score)</td></tr><tr><td>ISUP-Gradgruppe</td><td>5 (WHO 2016)</td></tr><tr><td>Positive Stanzen</td><td>7 von 12 (4 rechts, 3 links)</td></tr><tr><td>Tumoranteil gesamt</td><td>51%</td></tr><tr><td>Tumorlänge gesamt</td><td>52,7 mm</td></tr><tr><td>Anteil Gleason 4/5</td><td>77%</td></tr><tr><td>Perineurale Infiltration</td><td>Nachgewiesen</td></tr><tr><td>Periprostatische Fettinvasion</td><td>Nachgewiesen (apikal)</td></tr><tr><td>Samenblaseninfiltration</td><td>Nicht nachgewiesen</td></tr><tr><td>Lymphovaskuläre Invasion</td><td>Nicht nachgewiesen</td></tr><tr><td>Intraduktales Karzinom</td><td>Nicht nachgewiesen</td></tr><tr><td>ASAP</td><td>Nicht nachgewiesen</td></tr><tr><td>High-grade-PIN</td><td>Nicht nachgewiesen</td></tr></tbody></table><p><b>Diagnose:</b> Azinäres Adenokarzinom der Prostata (ICD-O 8140/3)</p></div>"
     ] ;
     fhir:Composition.section.entry [
       fhir:index 0 ;
       fhir:link <http://prostatecancerspec.org/DiagnosticReport/CoreNeedleBiopsyReport> ;
       fhir:Reference.reference [ fhir:value "DiagnosticReport/CoreNeedleBiopsyReport" ]
     ]
  ] .

# - ontology header ------------------------------------------------------------

<http://prostatecancerspec.org/Composition/CoreNeedleBiopsyComposition.ttl> a owl:Ontology ;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------