Document Bundle - BET Mamma - Breast Cancer Specification v0.1.0

Breast Cancer Specification - Local Development build (v0.1.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

Example Bundle: Document Bundle - BET Mamma

Document Details

Document Subject

Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)

Document Content

Pathologiebefundbericht

Klinische Angaben

Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links indiziert. Drahthäkchenmarkierung. Keine neoadjuvante Therapie. Ersterkrankung. Keine bekannte genetische Prädisposition. Präparateradiographie beigelegt.

Material

BET-Exzisionspräparat Mamma links, mit Haut, Drahthäkchen in situ

Makroskopie

Größe	42 × 35 × 18 mm
Gewicht	10 g
Quadrant	Unterer äußerer Quadrant
Zifferblatt	5 Uhr
Abstand Mamille	50 mm
Lamellierung	8 Scheiben à 5 mm
Schnittfläche	Grau-weißlich, derber Herdbefund zentral in Scheibe III–V, ca. 18 mm
Paraffinblöcke	7

Mikroskopie

Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Zentrale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion.

Diagnose

Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c

ICD-10	C50.5
ICD-O-3 Morphologie	M8500/3
Operatives Verfahren	BET (brusterhaltende Therapie)
Seitenlokalisation	Links
Fokalität	Unifokal
Max. Durchmesser invasiv	18 mm
Max. Gesamtdurchmesser	22 mm
Nottingham-Grad	Grad 2 (Score 6: Tubuli 3, Pleomorphie 2, Mitosen 1)
Assoziiertes DCIS	Vorhanden, ohne extensive intraduktale Komponente (EIC), intermediärer Kerngrad, kribriform, zentrale Komedo-Nekrosen
Tumorausdehnung	Auf Brustdrüse beschränkt
pT-Kategorie	pT1c

Resektionsränder

RR-Status invasiv	Nicht befallen (R0)
Nächster tumorfreier RR	Posterior
Mindestabstand invasiv	5 mm
RR-Status DCIS	Nicht befallen
Mindestabstand DCIS	3 mm

Biomarker

ER	Positiv (90%, stark)
PR	Positiv (60%, mäßig)
HER2 (IHC)	1+
HER2 (ISH)	Nicht amplifiziert
HER2-Gesamtstatus	Negativ
Ki-67	15%

Weitere Befunde

Lymphgefäßinvasion	Nicht nachgewiesen
Mikrokalzifikationen	In DCIS assoziiert

Kommentar: Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung.

Additional Resources Included in Document

Entry 2 - fullUrl = http://breastcancerspec.org/Patient/Patient4

Resource Patient:

Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)

Entry 3 - fullUrl = http://breastcancerspec.org/Organization/PathologyLabOrganization

Resource Organization:

identifier: http://example.hospital.de/organization-ids/ORG-PATH-001
name: Institut für Pathologie

Entry 4 - fullUrl = http://breastcancerspec.org/Practitioner/PathologistPractitioner

Resource Practitioner:

identifier: http://example.hospital.de/practitioner-ids/PATH-001
name: Elisabeth Hoffmann
Qualifications
- Code
* Pathology

Entry 5 - fullUrl = http://breastcancerspec.org/Practitioner/BreastSurgeonPractitioner

Resource Practitioner:

identifier: http://example.hospital.de/practitioner-ids/GYN-001
name: Thomas Richter
Qualifications
- Code
* Gynecology

Entry 6 - fullUrl = http://breastcancerspec.org/Encounter/BreastResectionEncounter

Resource Encounter:

identifier: http://example.hospital.de/encounters/E_25_210
status: completed
class: IMP
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)

Entry 7 - fullUrl = http://breastcancerspec.org/Condition/BreastResectionDiagnosisConfirmed

Resource Condition:

Profile: MII PR Diagnose Condition version: 2026.0.0
clinicalStatus: Active
verificationStatus: Confirmed
category: Encounter Diagnosis
code: Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_210; status = finished; class = IMP (IMP)
onset: 2025-01-15
recordedDate: 2025-02-05
note:
Z.n. Stanzbiopsie (E_25_105) mit Nachweis eines invasiven Mammakarzinoms NST, G2. BI-RADS 4b. BET links indiziert.

Entry 8 - fullUrl = http://breastcancerspec.org/ServiceRequest/BreastResectionReportRequest

Resource ServiceRequest:

Profile: MII PR Patho Service Request version: 2026.0.0
identifier: Placer Identifier/PATH-RPT-2025-210
status: Completed
intent: Order
category: Pathology consultation, comprehensive, records and specimen with report (procedure)
code: No display for ServiceRequest.code (concept: Pathology synoptic report)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
encounter: Encounter: identifier = http://example.hospital.de/encounters#E_25_210; status = finished; class = IMP (IMP)
requester: Practitioner Thomas Richter
performer: Practitioner Elisabeth Hoffmann
supportingInfo:
No display for ServiceRequest.supportingInfo (reference: ->Condition Bösartige Neubildung: Unterer äußerer Quadrant der Brustdrüse)
No display for ServiceRequest.supportingInfo (reference: ->Diagnostic Report for 'MG Breast Screening' for '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)')
No display for ServiceRequest.supportingInfo (reference: ->Observation Personal history of primary malignant neoplasm of breast (situation))
No display for ServiceRequest.supportingInfo (reference: ->Observation Cancer treatment --preoperative)
No display for ServiceRequest.supportingInfo (reference: ->Observation Lesion size, largest dimension (observable entity))
No display for ServiceRequest.supportingInfo (reference: ->Observation Insertion of marker into breast using X-ray guidance (procedure))
No display for ServiceRequest.supportingInfo (reference: ->Observation 80865008|Specimen mammography|:363702006|Has focus|=185008008|Medical reports sent|)
No display for ServiceRequest.supportingInfo (reference: ->Observation Diathesis, function (observable entity))
No display for ServiceRequest.supportingInfo (reference: ->Observation Quadrant Breast)
No display for ServiceRequest.supportingInfo (reference: ->Observation Radial position in breast [Angle] in Breast cancer specimen)
No display for ServiceRequest.supportingInfo (reference: ->Observation Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity))
No display for ServiceRequest.supportingInfo (reference: ->Observation Screening interpretation (observable entity))
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.

Entry 9 - fullUrl = http://breastcancerspec.org/DiagnosticReport/BreastResectionImagingReport

Resource DiagnosticReport:

MG Breast Screening (Radiology)
Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
When For 2025-01-08
Report Details
BI-RADS 4b: Herdbefund linke Brust, unterer äußerer Quadrant, 5 Uhr, 5 cm von Mamille. Radiologische Ausdehnung ca. 15 mm. Mammografie und Ultraschall. Indikation zur BET.

Entry 10 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionCancerHistory

Resource Observation:

status: Final
code: Brustkrebsvorgeschichte
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: Ersterkrankung

Entry 11 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionPriorTherapy

Resource Observation:

status: Final
code: Vorchirurgische Therapie bei invasivem Karzinom
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: Keine neoadjuvante Therapie

Entry 12 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionRadiologicalExtent

Resource Observation:

status: Final
code: Radiologische Ausdehnung
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: 15 mm (Details: UCUM codemm = 'mm')

Entry 13 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionSpecimenMarking

Resource Observation:

status: Final
code: Befundmarkierung
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: Drahthäkchen

Entry 14 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionSpecimenRadiographyClinical

Resource Observation:

status: Final
code: Präparateradiographie beigelegt
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: Ja, beigelegt

Entry 15 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionGeneticPredisposition

Resource Observation:

status: Final
code: Genetische Prädisposition
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
value: Nicht bekannt

Entry 16 - fullUrl = http://breastcancerspec.org/DiagnosticReport/BreastResectionReport

Resource DiagnosticReport:

Profile: MII PR Patho Report version: 2026.0.0
Pathology Synoptic report (Surgical Pathology)
Subject Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
When For 2025-02-10 14:00:00+0100
Reported 2025-02-10 17:00:00+0100
Performer Practitioner Elisabeth Hoffmann
Identifier Accession ID/E_25_210
Report Details
Code Value Flags When For
Pathology report gross observation Narrative (Breast structure (body structure)) Final 2025-02-06 08:30:00+0100
Pathology report final diagnosis Narrative Final 2025-02-10
Invasives Mammakarzinom NST (ICD-O 8500/3), pT1c, Nottingham Grad 2 (Score 6: Tubuli 3, Kernpleomorphie 2, Mitosen 1). Begleitendes DCIS, intermediärer Kerngrad, kribriform, fokale Komedo-Nekrosen. Alle Resektionsränder tumorfrei (invasiv 5 mm, DCIS 3 mm). Keine LVI. ER+ (90%), PR+ (60%), HER2 1+ (nicht amplifiziert), Ki-67 15%.

Entry 17 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenPart

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: Placer Identifier/OP25_210_A, Filler Identifier/E_25_210_A
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Specimen from breast obtained by excision (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
request: ServiceRequest Pathology synoptic report
Collections
- Collector Collected[x] Method BodySite
* Practitioner Thomas Richter 2025-02-05 10:00:00+0100 Wide local excision of breast lesion (procedure) No display for Specimen.collection.bodySite (concept: Structure of lower outer quadrant of breast (body structure))
container
note:
BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.

Entry 18 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:00:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe III 2025-02-06 08:00:00+0100
container

Entry 19 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock02

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_2
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:10:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Tumor zentral, Scheibe V 2025-02-06 08:10:00+0100
container

Entry 20 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock03

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_3
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:20:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Resektionsrand superior 2025-02-06 08:20:00+0100
container

Entry 21 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock04

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_4
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:25:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Resektionsrand inferior 2025-02-06 08:25:00+0100
container

Entry 22 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock05

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_5
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:30:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Resektionsrand medial (Scheibe I) 2025-02-06 08:30:00+0100
container

Entry 23 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock06

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_6
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:35:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Resektionsrand lateral (Scheibe VIII) 2025-02-06 08:35:00+0100
container

Entry 24 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenBlock07

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_7
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue block specimen (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
Collections
- Collected[x] Method
* 2025-02-06 08:40:00+0100 Gross examination and sampling of tissue specimen (procedure)
Processings
- Extension Description Time[x]
* Zuschnitt und Paraffineinbettung - Resektionsrand posterior 2025-02-06 08:40:00+0100
container

Entry 25 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:00:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung (Schnittstufe 1)
time: 2025-02-06 09:00:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:15:00+0100
container

Entry 26 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHE02

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HE_02
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:00:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung (Schnittstufe 2)
time: 2025-02-06 09:00:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:15:00+0100
container

Entry 27 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideER01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_ER_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:30:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:30:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: ER-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:00:00+0100
container

Entry 28 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlidePR01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_PR_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:35:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:35:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: PR-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:05:00+0100
container

Entry 29 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideHER2IHC01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_HER2IHC_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:40:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:40:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HER2-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:30:00+0100
container

Entry 30 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideKi67-01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_Ki67_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:45:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:45:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Ki-67 Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:10:00+0100
container

Entry 31 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideCK18-01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_CK18_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:50:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:50:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: CK18-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:35:00+0100
container

Entry 32 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlidep40-01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_p40_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:55:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:55:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: p40-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:40:00+0100
container

Entry 33 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideECad-01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_1_1_ECad_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 10:00:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 10:00:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: E-Cadherin-Immunhistochemie
additive: Substance Tissue stain (substance)
time: 2025-02-06 10:45:00+0100
container

Entry 34 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideBlock02-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_2_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:20:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung (Schnittstufe 1)
time: 2025-02-06 09:20:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:35:00+0100
container

Entry 35 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideBlock02-HE02

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_2_1_HE_02
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_2; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:20:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung (Schnittstufe 2)
time: 2025-02-06 09:20:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:35:00+0100
container

Entry 36 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Superior-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_3_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_3; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:25:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:25:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:40:00+0100
container

Entry 37 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Inferior-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_4_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_4; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:28:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:28:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:43:00+0100
container

Entry 38 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Medial-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_5_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_5; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:31:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:31:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:46:00+0100
container

Entry 39 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Lateral-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_6_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_6; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:34:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:34:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:49:00+0100
container

Entry 40 - fullUrl = http://breastcancerspec.org/Specimen/BreastResectionSpecimenSlideRR-Posterior-HE01

Resource Specimen:

Profiles: MII PR Patho Specimen version: 2026.0.0, MII PR Biobank Specimen Bioprobe Core version: 2026.0.0
identifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210_A_7_1_HE_01
accessionIdentifier: https://pathologie.example-hospital.de/fhir/fn/befundbericht/E_25_210
status: Available
type: Tissue section (specimen)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
parent: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue block specimen (specimen)
Collections
- Collected[x] Method
* 2025-02-06 09:37:00+0100 Tissue processing technique (procedure)
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: Schnittherstellung
time: 2025-02-06 09:37:00+0100
processing
MII EX Biobank Temperaturbedingungen: 20-25 °C
description: HE-Färbung
time: 2025-02-06 09:52:00+0100
container

Entry 41 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstanceER

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
Estrogen Receptor (Dako Omnis)

Entry 42 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstancePR

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
Progesterone Receptor (Dako Omnis)

Entry 43 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstanceHER2IHC

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
VENTANA HER2 (4B5), Roche

Entry 44 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstanceKi67

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
Ki-67 Antigen (Dako Omnis)

Entry 45 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstanceCK18

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
Cytokeratin 18 (DC10), Dako Omnis

Entry 46 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstancep40

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
p40 (BC28), Biocare Medical

Entry 47 - fullUrl = http://breastcancerspec.org/Substance/BreastResectionSubstanceECadherin

Resource Substance:

Profile: MII PR Biobank Substance Additiv version: 2026.0.0
status: Active
category: Chemical
code: No display for Substance.code (concept: Tissue stain (substance))
description:
E-Cadherin (NCH-38), Dako Omnis

Entry 48 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroscopicGrouper

Resource Observation:

Profile: MII PR Patho Macroscopic Grouper version: 2026.0.0
status: Final
category: Laboratory
code: Pathology report gross observation Narrative
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
bodySite: Breast structure (body structure)
hasMember:
Observation Specimen size.maximum dimension in Breast tumor
Observation Specimen size additional dimension 1 in Breast tumor
Observation Specimen size additional dimension 2 in Breast tumor
Observation Specimen wt Tiss Qn
Observation Quadrant Breast
Observation Radial position in breast [Angle] in Breast cancer specimen
Observation Distance of primary malignant neoplasm of breast to nipple in excised breast specimen (observable entity)
Observation Number of paraffin embedded tissue blocks examined from excised specimen (observable entity)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 49 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroLength

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: ProbeGröße1
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 42 mm (Details: UCUM codemm = 'mm')
bodySite: Breast structure (body structure)
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 50 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroWidth

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: ProbeGröße2
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 35 mm (Details: UCUM codemm = 'mm')
bodySite: Breast structure (body structure)
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 51 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroDepth

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: ProbeGröße3
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 18 mm (Details: UCUM codemm = 'mm')
bodySite: Breast structure (body structure)
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 52 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroWeight

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: Gewicht der Probe
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 10 g (Details: UCUM codeg = 'g')
bodySite: Breast structure (body structure)
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 53 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroQuadrant

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: Quadrantenlokalisaion
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: Unterer äußerer Quadrant
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 54 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroClock

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: Zifferblattlokalisation
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 5 o'clock (Details: UCUM code{clock position} = '{clock position}')
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 55 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroDistanceNipple

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: Abstand von der Mamille
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 50 mm (Details: UCUM codemm = 'mm')
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 56 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMacroBlockCount

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
status: Final
category: Laboratory, Pathology report gross observation Narrative
code: Anzahl Paraffinblöcke
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-06 08:30:00+0100
performer: Practitioner Elisabeth Hoffmann
value: 6 Blöcke (Details: UCUM code{blocks} = '{blocks}')
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 57 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionDiagnosticConclusionGrouper

Resource Observation:

Profile: MII PR Patho Diagnostic Conclusion Grouper version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory
code: Pathology report final diagnosis Narrative
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
hasMember:
Observation Surgery procedure
Observation Specimen type
Observation Specimen laterality (observable entity)
Observation Body structure included in specimen [Anatomy] in Specimen
Observation Qualitative distribution of primary malignant neoplasm of breast in excised breast specimen (observable entity)
Observation Inv comp size max dim BT
Observation Size.maximum dimension in Tumor
Observation Histo type BT
Observation Histology type in Cancer specimen Narrative
Observation Nottingham combined grade of primary malignant neoplasm of breast (observable entity)
Observation Nottingham total score of primary malignant neoplasm of breast (observable entity)
Observation Number of mitoses per 10 high power fields (observable entity)
Observation DCIS intraduct ext Br ca spec Ql Micro
Observation Nuclear grade of ductal carcinoma in situ of breast (observable entity)
Observation Growth pattern of DCIS [Type] in Breast cancer specimen by Light microscopy
Observation DCIS necrosis [Type] in Breast cancer specimen by Light microscopy
Observation Adjacent structure invaded by tumor [Anatomy] in Breast cancer specimen by Light microscopy
Observation Margin involved BT
Observation IC uninv marg closest BT
Observation IC uninv marg dist closest BT
Observation Surgical margin DCIS involvement [Presence] in Breast cancer specimen by Light microscopy
Observation DCIS.uninv marg dist.closest BT
Observation Lymph-vascular invasion Ca spec
Observation Presence of microcalcification in excised breast specimen (observable entity)
Observation Estrogen receptor [Interpretation] in Tissue
Observation Cells.estrogen receptor/cells in Breast cancer specimen by Immune stain
Observation Estrogen receptor fluorescence intensity [Type] in Breast cancer specimen by Immune stain
Observation Progesterone receptor [Interpretation] in Tissue
Observation Cells.progesterone receptor/cells in Breast cancer specimen by Immune stain
Observation Intensity of stain of progesterone receptor in primary malignant neoplasm of breast by immunohistochemistry (observable entity)
Observation HER2 [Presence] in Breast cancer specimen by Immune stain
Observation Presence of receptor tyrosine-protein kinase erbB-2 in primary malignant neoplasm of breast by in situ hybridization (observable entity)
Observation HER2 [Interpretation] in Tissue
Observation Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain
Observation pT category (observable entity)
Observation Pathology report comments [Interpretation] Narrative
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 58 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionOperativeProcedure

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Operatives Verfahren
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Brusterhaltende Therapie (BET)
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 59 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMaterialType

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Materialart
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Exzisionspräparat
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 60 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionLaterality

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Seitenlokalisation der Probe
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Links
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 61 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionAttachedTissue

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Material/anhängendes Gewebe
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Haut
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 62 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionFocality

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: (Multi)fokalität
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Unifokal
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 63 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMaxDiameterInvasive

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Maximaler Durchmesser invasives Karzinom
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 18 mm (Details: UCUM codemm = 'mm')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 64 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMaxOverallDiameter

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Maximaler Gesamtdurchmesser der Läsion
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 22 mm (Details: UCUM codemm = 'mm')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 65 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionHistologicalType

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Histologischer Tumortyp WHO
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Invasives duktales Karzinom (NST)
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 66 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMorphologyFreeText

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Morphologie Freitext
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Invasives Mammakarzinom des NST (kein spezieller Typ), maximal 18 mm messend. Das Karzinom zeigt ein überwiegend trabekuläres und solides Wachstumsmuster mit mäßiger Kern- und Zellpolymorphie. Mitosen sind vereinzelt nachweisbar (4/10 HPF). In der Tumorperipherie zeigt sich ein begleitendes duktales Carcinoma in situ (DCIS) mit intermediärem Kerngrad und überwiegend kribriformem Wachstumsmuster, maximal 8 mm. Fokale Komedo-Nekrosen. Assoziierte Mikroverkalkungen im DCIS-Areal. Alle Resektionsränder tumorfrei. Mindestabstand invasiv: 5 mm (posterior), DCIS: 3 mm. Keine Lymphgefäßinvasion.
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 67 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionNottinghamGrade

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Histologischer Tumorgrad (Nottingham-Grad)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Nottingham Grad 2
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom:
Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Observation Nottingham total score of primary malignant neoplasm of breast (observable entity)

Entry 68 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionNottinghamSummaryScore

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Elston-Ellis-Summenscore
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 6 score (Details: UCUM code{score} = '{score}')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
component
code: Glandular differentiation [Score] in Breast cancer specimen by Nottingham
value: 3 score (Details: UCUM code{score} = '{score}')
component
code: Nuclear pleomorphism in Breast tumor by Nottingham
value: 2 score (Details: UCUM code{score} = '{score}')
component
code: Mitotic rate [Score] in Breast cancer specimen by Nottingham
value: 1 score (Details: UCUM code{score} = '{score}')

Entry 69 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMitosisCount

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Mitosezahl
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 4 per 10 HPF (Details: UCUM code{HPF} = '{HPF}')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 70 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionAssociatedDCIS

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Klassifikation eines assoziiertes DCIS
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: DCIS vorhanden, ohne extensive intraduktale Komponente (EIC)
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 71 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionDCISGrade

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Kerngrading / WHO-Grading nichtinvasiv
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Intermediär (Grad 2)
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 72 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionDCISArchitecture

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: DCIS Architektur
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: kribriformer Typ
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 73 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionDCISNecrosis

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Nekrosen
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Zentral (Komedo-Nekrosen)
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 74 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionTumorExtent

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Tumorausdehnung
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Auf Brustdrüse beschränkt
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 75 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMarginStatusInvasive

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Resektionsrandstatus invasiv
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Nicht befallen (R0)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 76 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionClosestMargin

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Richtung des nächsten tumorfreien RR
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Posterior
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 77 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMinDistanceInvasive

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Mindestabstand des invasiven Tumor zum nächstgelegenen Resektionsrand
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 5 mm (Details: UCUM codemm = 'mm')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_7_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 78 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMarginStatusNonInvasive

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Resektionsrandstatus nichtinvasiv
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Nicht befallen
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 79 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMinDistanceNonInvasive

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Mindestabstand vom RR zum nichtinvasiven Tumor
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 3 mm (Details: UCUM codemm = 'mm')
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 80 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionLVI

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Peritumorale Gefäßinvasion
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Nicht nachgewiesen
specimen: Specimen: identifier = Placer Identifier,Filler Identifier; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Specimen from breast obtained by excision (specimen); note = BET-Exzisionspräparat Mamma links, unterer äußerer Quadrant, 5 Uhr, 50 mm von Mamille. Mit Haut, Drahthäkchen in situ.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 81 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionMicrocalcification

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Presence of microcalcification in excised breast specimen (observable entity)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Microcalcifications present in DCIS
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HE_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 82 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionERStatus

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Hormonrezeptorstatus Östrogen
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Positiv
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ESR1

Entry 83 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionERPercentage

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: PP ER
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 90 % (Details: UCUM code% = '%')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ESR1

Entry 84 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionERIntensity

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Färbeintensität ER
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Stark
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_ER_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ESR1

Entry 85 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionPRStatus

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Hormonrezeptorstatus Progesteron
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Positiv
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] PGR

Entry 86 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionPRPercentage

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: PP PR
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 60 % (Details: UCUM code% = '%')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] PGR

Entry 87 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionPRIntensity

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Färbeintensität PR
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Mäßig
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_PR_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] PGR

Entry 88 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionHER2IHC

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Her2 Score
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 1+
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ERBB2

Entry 89 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionHER2ISH

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Her2 Amplifikation
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Nicht amplifiziert
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ERBB2

Entry 90 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionHER2Overall

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Her2neuStatus
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Negativ
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_HER2IHC_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] ERBB2

Entry 91 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionKi67

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Ki67-Index
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: 15 % (Details: UCUM code% = '%')
specimen: Specimen: identifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210_A_1_1_Ki67_01; accessionIdentifier = https://pathologie.example-hospital.de/fhir/fn/befundbericht#E_25_210; status = available; type = Tissue section (specimen)
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'
Components
- Code Value[x]
* Gene studied [ID] MKI67

Entry 92 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionPT

Resource Observation:

Profile: MII PR Onkologie TNM T-Kategorie version: 2026.0.0
status: Final
code: pT category (observable entity)
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
value: T1
method: 8. Auflage

Entry 93 - fullUrl = http://breastcancerspec.org/Observation/BreastResectionComment

Resource Observation:

Profile: MII PR Patho Finding version: 2026.0.0
basedOn: ServiceRequest Pathology synoptic report
status: Final
category: Laboratory, Pathology report final diagnosis Narrative
code: Kommentar
subject: Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)
effective: 2025-02-10
performer: Practitioner Elisabeth Hoffmann
value: Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung.
derivedFrom: Response to Questionnaire 'http://breastcancerspec.org/Questionnaire/OP-Mamma' about '->Sabine Becker Female, DoB: 1971-03-15 ( http://example.hospital.de/patient-ids#PAT-2025-105)'

Entry 94 - fullUrl = http://breastcancerspec.org/QuestionnaireResponse/QuestionnaireResponseBreastResection

Resource QuestionnaireResponse:

LinkID Text Definition Answer
QuestionnaireResponseBreastResection Questionnaire:http://breastcancerspec.org/Questionnaire/OP-Mamma

bet.root BET Mamma

bet.clinical Klinische Angaben

11951 Proben limitiert auswertbar SNOMED CT: 373067005 (No (qualifier value))

11912 Präsentationsmodus Frisch

11147 Klinische Befunde / Anlass Z.n. Stanzbiopsie mit Nachweis eines invasiven Mammakarzinoms NST, G2

11923 Brustkrebsvorgeschichte Ersterkrankung

11952 Vorchirurgische Therapie SNOMED CT: 373067005 (No (qualifier value))

11918 Bildgebungsmodalität Mammografie, Ultraschall

11953 Radiologische Ausdehnung 15 mm (Details: UCUM codemm = 'mm')

10160 Befundmarkierung Drahthäkchen

10130 Präparateradiographie Ja, beigelegt

11954 Genetische Prädisposition Nicht bekannt

bet.macro Makroskopie

10900 Probengröße 1 (Länge) 65 mm (Details: UCUM codemm = 'mm')

10910 Probengröße 2 (Breite) 45 mm (Details: UCUM codemm = 'mm')

10920 Probengröße 3 (Tiefe) 30 mm (Details: UCUM codemm = 'mm')

10890 Gewicht 55 g (Details: UCUM codeg = 'g')

10030 Quadrant SNOMED CT: 33564002 (Structure of lower outer quadrant of breast (body structure))

10040 Zifferblattlokalisation 5 Uhr

10070 Abstand Mamille 50 mm (Details: UCUM codemm = 'mm')

bet.general Allgemeine Befunde

11130 Nichtinvasive Läsion SNOMED CT: 52101004 (Present (qualifier value))

11270 Invasives Karzinom SNOMED CT: 52101004 (Present (qualifier value))

11919 Operatives Verfahren SNOMED CT: 237371007 (Wide local excision of breast lesion (procedure))

10140 Materialart Exzisionspräparat

10800 Seitenlokalisation SNOMED CT: 7771000 (Left (qualifier value))

11040 Anhängendes Gewebe Haut

11440 Fokalität Unifokal

bet.invasive Invasives Karzinom

11400 Max Durchmesser invasiv 18 mm (Details: UCUM codemm = 'mm')

11420 Max Gesamtdurchmesser 22 mm (Details: UCUM codemm = 'mm')

11280 Histologischer Tumortyp unknown: 8500/3 (Invasives duktales Karzinom (NST))

11290 Morphologie Freitext Invasives Mammakarzinom des NST, überwiegend trabekuläres und solides Wachstumsmuster

11330 Nottingham-Grad G2

11340 Tubulus-Score 3

11350 Kernpleomorphie-Score 2

11925 Mitosezahl 4/10 HPF

11360 Mitoserate-Score 1

11390 Elston-Ellis-Summenscore 6

11300 Assoziiertes DCIS SNOMED CT: 52101004 (Present (qualifier value))

149 DCIS Kerngrading Intermediär (Grad 2)

150 DCIS Architektur Kribriform

151 DCIS Nekrosen Fokal (Komedo-Nekrosen)

11926 Tumorausdehnung Auf Brustdrüse beschränkt

bet.margins Resektionsränder

11470 RR-Status invasiv SNOMED CT: 2667000 (Absent (qualifier value))

11490 Nächster tumorfreier RR Posterior

11480 Mindestabstand invasiv 5 mm (Details: UCUM codemm = 'mm')

11968 RR-Status nichtinvasiv SNOMED CT: 2667000 (Absent (qualifier value))

11970 Mindestabstand nichtinvasiv 3 mm (Details: UCUM codemm = 'mm')

bet.additional Weitere Befunde

11430 LVI SNOMED CT: 2667000 (Absent (qualifier value))

10880 Mikrokalzifikationen In DCIS assoziiert

bet.biomarkers Biomarker

11750 ER-Status SNOMED CT: 52101004 (Present (qualifier value))

11720 ER Prozent 90

11730 ER Färbeintensität Stark

11790 PR-Status SNOMED CT: 52101004 (Present (qualifier value))

11760 PR Prozent 60

11770 PR Färbeintensität Mäßig

11810 HER2-Score (IHC) 1+

11820 HER2-Amplifikation (ISH) Nicht amplifiziert

11830 HER2-Gesamtstatus Negativ

11840 Ki-67-Index 15

bet.tnm TNM

169 pT-Kategorie pT1c

bet.comment Kommentar

11900 Kommentar Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung.

Documentation for this format

LinkID	Text	Answer
QuestionnaireResponseBreastResection		Questionnaire:http://breastcancerspec.org/Questionnaire/OP-Mamma
bet.root	BET Mamma
bet.clinical	Klinische Angaben
11951	Proben limitiert auswertbar	SNOMED CT: 373067005 (No (qualifier value))
11912	Präsentationsmodus	Frisch
11147	Klinische Befunde / Anlass	Z.n. Stanzbiopsie mit Nachweis eines invasiven Mammakarzinoms NST, G2
11923	Brustkrebsvorgeschichte	Ersterkrankung
11952	Vorchirurgische Therapie	SNOMED CT: 373067005 (No (qualifier value))
11918	Bildgebungsmodalität	Mammografie, Ultraschall
11953	Radiologische Ausdehnung	15 mm (Details: UCUM codemm = 'mm')
10160	Befundmarkierung	Drahthäkchen
10130	Präparateradiographie	Ja, beigelegt
11954	Genetische Prädisposition	Nicht bekannt
bet.macro	Makroskopie
10900	Probengröße 1 (Länge)	65 mm (Details: UCUM codemm = 'mm')
10910	Probengröße 2 (Breite)	45 mm (Details: UCUM codemm = 'mm')
10920	Probengröße 3 (Tiefe)	30 mm (Details: UCUM codemm = 'mm')
10890	Gewicht	55 g (Details: UCUM codeg = 'g')
10030	Quadrant	SNOMED CT: 33564002 (Structure of lower outer quadrant of breast (body structure))
10040	Zifferblattlokalisation	5 Uhr
10070	Abstand Mamille	50 mm (Details: UCUM codemm = 'mm')
bet.general	Allgemeine Befunde
11130	Nichtinvasive Läsion	SNOMED CT: 52101004 (Present (qualifier value))
11270	Invasives Karzinom	SNOMED CT: 52101004 (Present (qualifier value))
11919	Operatives Verfahren	SNOMED CT: 237371007 (Wide local excision of breast lesion (procedure))
10140	Materialart	Exzisionspräparat
10800	Seitenlokalisation	SNOMED CT: 7771000 (Left (qualifier value))
11040	Anhängendes Gewebe	Haut
11440	Fokalität	Unifokal
bet.invasive	Invasives Karzinom
11400	Max Durchmesser invasiv	18 mm (Details: UCUM codemm = 'mm')
11420	Max Gesamtdurchmesser	22 mm (Details: UCUM codemm = 'mm')
11280	Histologischer Tumortyp	unknown: 8500/3 (Invasives duktales Karzinom (NST))
11290	Morphologie Freitext	Invasives Mammakarzinom des NST, überwiegend trabekuläres und solides Wachstumsmuster
11330	Nottingham-Grad	G2
11340	Tubulus-Score	3
11350	Kernpleomorphie-Score	2
11925	Mitosezahl	4/10 HPF
11360	Mitoserate-Score	1
11390	Elston-Ellis-Summenscore	6
11300	Assoziiertes DCIS	SNOMED CT: 52101004 (Present (qualifier value))
149	DCIS Kerngrading	Intermediär (Grad 2)
150	DCIS Architektur	Kribriform
151	DCIS Nekrosen	Fokal (Komedo-Nekrosen)
11926	Tumorausdehnung	Auf Brustdrüse beschränkt
bet.margins	Resektionsränder
11470	RR-Status invasiv	SNOMED CT: 2667000 (Absent (qualifier value))
11490	Nächster tumorfreier RR	Posterior
11480	Mindestabstand invasiv	5 mm (Details: UCUM codemm = 'mm')
11968	RR-Status nichtinvasiv	SNOMED CT: 2667000 (Absent (qualifier value))
11970	Mindestabstand nichtinvasiv	3 mm (Details: UCUM codemm = 'mm')
bet.additional	Weitere Befunde
11430	LVI	SNOMED CT: 2667000 (Absent (qualifier value))
10880	Mikrokalzifikationen	In DCIS assoziiert
bet.biomarkers	Biomarker
11750	ER-Status	SNOMED CT: 52101004 (Present (qualifier value))
11720	ER Prozent	90
11730	ER Färbeintensität	Stark
11790	PR-Status	SNOMED CT: 52101004 (Present (qualifier value))
11760	PR Prozent	60
11770	PR Färbeintensität	Mäßig
11810	HER2-Score (IHC)	1+
11820	HER2-Amplifikation (ISH)	Nicht amplifiziert
11830	HER2-Gesamtstatus	Negativ
11840	Ki-67-Index	15
bet.tnm	TNM
169	pT-Kategorie	pT1c
bet.comment	Kommentar
11900	Kommentar	Korrelation mit dem Vorbefund der Stanzbiopsie (E_25_105): Übereinstimmende Histologie (invasives Mammakarzinom NST, G2). Biomarkerprofil bestätigt: ER+, PR+, HER2-, Luminal-A-like. Empfehlung: Tumorkonferenz zur weiteren Therapieplanung.
Documentation for this format