Implementierungsleitfaden Therapieziele Onkologie
1.0.0-ballot - Ballot Germany

Implementierungsleitfaden Therapieziele Onkologie - Local Development build (v1.0.0-ballot) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions

: Transaction-Bundle – Mammakarzinom neoadjuvant (Beispiel)

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{
  "resourceType" : "Bundle",
  "id" : "BundleMammaNeoadjuvant",
  "language" : "en",
  "type" : "transaction",
  "entry" : [
    {
      "fullUrl" : "http://example.org/fhir/Patient/PatientinMamma",
      "resource" : {
        "resourceType" : "Patient",
        "id" : "PatientinMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "name" : [
          {
            "family" : "Baumann",
            "given" : [
              "Sabine"
            ]
          }
        ],
        "gender" : "female",
        "birthDate" : "1977-06-24"
      },
      "request" : {
        "method" : "POST",
        "url" : "Patient"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Practitioner/OnkologinMamma",
      "resource" : {
        "resourceType" : "Practitioner",
        "id" : "OnkologinMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "name" : [
          {
            "family" : "Musterarzt",
            "given" : [
              "Katrin"
            ]
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Practitioner"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Organization/TumorzentrumMamma",
      "resource" : {
        "resourceType" : "Organization",
        "id" : "TumorzentrumMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "name" : "Zertifiziertes Brustzentrum Musterklinik"
      },
      "request" : {
        "method" : "POST",
        "url" : "Organization"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Organization/Tumorboard",
      "resource" : {
        "resourceType" : "Organization",
        "id" : "Tumorboard",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "identifier" : [
          {
            "system" : "https://www.musterklinik.de/fhir/sid/organisationen",
            "value" : "tumorboard-brust-001"
          }
        ],
        "active" : true,
        "type" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/organization-type",
                "code" : "team",
                "display" : "Organizational team"
              }
            ]
          }
        ],
        "name" : "Zertifiziertes Brustzentrum Musterklinik"
      },
      "request" : {
        "method" : "POST",
        "url" : "Organization"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestBiopsieMamma",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestBiopsieMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "intent" : "order",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "44578009",
              "display" : "Core needle biopsy of breast (procedure)"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "authoredOn" : "2025-09-12",
        "requester" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestPathologieMamma",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestPathologieMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "intent" : "order",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "788124003",
              "display" : "Histopathology service (qualifier value)"
            }
          ],
          "text" : "Histopathologische Untersuchung inkl. Rezeptor-/HER2-Status und Ki-67"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "authoredOn" : "2025-09-15",
        "requester" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "specimen" : [
          {
            🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestStagingMamma",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestStagingMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "intent" : "order",
        "code" : {
          "text" : "Klinische Ausbreitungsdiagnostik / TNM-Staging"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "authoredOn" : "2025-09-15",
        "requester" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestGBRCAMamma",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestGBRCAMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "intent" : "order",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "21639-0",
              "display" : "BRCA1 gene mutations tested for in Blood or Tissue by Molecular genetics method Nominal"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "authoredOn" : "2025-09-18",
        "requester" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/CarePlan/CarePlanMammaDiagnostik",
      "resource" : {
        "resourceType" : "CarePlan",
        "id" : "CarePlanMammaDiagnostik",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-diagnostic-care-plan"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "active",
        "intent" : "plan",
        "category" : [
          {
            "text" : "Tumordiagnostik"
          }
        ],
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "author" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "goal" : [
          {
            🔗 "reference" : "Goal/DiagnosticGoal"
          }
        ],
        "activity" : [
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Procedure/ProcedureBiopsieMamma"
              }
            ],
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestBiopsieMamma"
            }
          },
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Observation/ObsHistologieMamma"
              },
              {
                🔗 "reference" : "Observation/ObsGradingMamma"
              },
              {
                🔗 "reference" : "Observation/ObsEstrogenrezeptorMamma"
              },
              {
                🔗 "reference" : "Observation/ObsProgesteronrezeptorMamma"
              },
              {
                🔗 "reference" : "Observation/ObsHER2Mamma"
              },
              {
                🔗 "reference" : "Observation/ObsKi67Mamma"
              }
            ],
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestPathologieMamma"
            }
          },
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Observation/ObsTNMklinischMamma"
              }
            ],
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestStagingMamma"
            }
          },
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Observation/ObsGBRCAMamma"
              }
            ],
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestGBRCAMamma"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "CarePlan"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Goal/DiagnosticGoal",
      "resource" : {
        "resourceType" : "Goal",
        "id" : "DiagnosticGoal",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-goal"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "individual",
                "valueReference" : {
                  🔗 "reference" : "Patient/PatientinMamma"
                }
              },
              {
                "url" : "status",
                "valueCode" : "agree"
              },
              {
                "url" : "priority",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
                      "code" : "high-priority",
                      "display" : "High Priority"
                    }
                  ]
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-acceptance"
          }
        ],
        "lifecycleStatus" : "active",
        "achievementStatus" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-achievement",
              "code" : "in-progress",
              "display" : "In Progress"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "261004008",
                "display" : "Diagnostic intent"
              }
            ]
          }
        ],
        "priority" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
              "code" : "high-priority",
              "display" : "High Priority"
            }
          ]
        },
        "description" : {
          "text" : "Diagnosesicherung für die Verdachtsdiagnose"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "startDate" : "2025-09-12",
        "target" : [
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21905-5",
                  "display" : "Primary tumor.clinical [Class] Cancer"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21906-3",
                  "display" : "Regional lymph nodes.clinical [Class] Cancer"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21907-1",
                  "display" : "Distant metastases.clinical [Class] Cancer"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21908-9",
                  "display" : "Stage group.clinical Cancer"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "40556-3",
                  "display" : "Estrogen receptor Ag [Presence] in Tissue by Immune stain"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "85339-0",
                  "display" : "Progesterone receptor Ag [Presence] in Breast cancer specimen by Immune stain"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48676-1",
                  "display" : "HER2 Ag [Interpretation] in Tissue"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21855-2",
                  "display" : "Primary site Cancer"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "44648-4",
                  "display" : "Histologic grade [Score] in Breast cancer specimen by Nottingham"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "33732-9",
                  "display" : "Histology grade [Identifier] in Cancer specimen"
                }
              ]
            }
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "85347-3",
                  "display" : "Sentinel lymph nodes examined [#] in Cancer specimen by Light microscopy"
                }
              ]
            }
          }
        ],
        "expressedBy" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "outcomeReference" : [
          {
            🔗 "reference" : "Observation/ObsDiseaseStatusMamma"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Goal"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Condition/ConditionMamma",
      "resource" : {
        "resourceType" : "Condition",
        "id" : "ConditionMamma",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-condition"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/StructureDefinition/condition-assertedDate",
            "valueDateTime" : "2025-09-15"
          }
        ],
        "clinicalStatus" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/condition-clinical",
              "code" : "active"
            }
          ]
        },
        "verificationStatus" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/condition-ver-status",
              "code" : "confirmed"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/condition-category",
                "code" : "encounter-diagnosis"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
              "version" : "2026",
              "code" : "C50.4",
              "display" : "Bösartige Neubildung: Oberer äußerer Quadrant der Brustdrüse"
            }
          ],
          "text" : "Invasives Mammakarzinom links, oberer äußerer Quadrant (NST), triple-negativ"
        },
        "bodySite" : [
          {
            "text" : "Mamma links, oberer äußerer Quadrant"
          }
        ],
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "onsetDateTime" : "2025-09-15",
        "recordedDate" : "2025-09-15"
      },
      "request" : {
        "method" : "POST",
        "url" : "Condition"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Procedure/ProcedureBiopsieMamma",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ProcedureBiopsieMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "category" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "103693007",
              "display" : "Diagnostic procedure (procedure)"
            }
          ]
        },
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "44578009",
              "display" : "Core needle biopsy of breast (procedure)"
            }
          ],
          "text" : "Sonografisch gesteuerte Stanzbiopsie der Mamma links"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "performedDateTime" : "2025-09-15",
        "reasonReference" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "bodySite" : [
          {
            "text" : "Mamma links, oberer äußerer Quadrant"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Specimen/SpecimenBiopsieMamma",
      "resource" : {
        "resourceType" : "Specimen",
        "id" : "SpecimenBiopsieMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "available",
        "type" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "122737001",
              "display" : "Specimen from breast obtained by core needle biopsy"
            },
            {
              "system" : "http://snomed.info/sct",
              "code" : "119376003",
              "display" : "Tissue specimen (specimen)"
            }
          ],
          "text" : "Stanzbiopsat (Gewebeprobe) Mamma links"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "collection" : {
          "collectedDateTime" : "2025-09-15",
          "method" : {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "9911007",
                "display" : "Core needle biopsy"
              }
            ]
          },
          "bodySite" : {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "76365002",
                "display" : "Structure of upper outer quadrant of breast"
              }
            ],
            "text" : "Mamma links, oberer äußerer Quadrant"
          }
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Specimen"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsHistologieMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsHistologieMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "59847-4",
              "display" : "Histology and Behavior ICD-O-3 Cancer"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-15",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "82711006",
              "display" : "Infiltrating duct carcinoma"
            },
            {
              "system" : "urn:oid:2.16.840.1.113883.6.43.1",
              "code" : "8500/3",
              "display" : "Invasives duktales Karzinom / Karzinom ohne speziellen Typ (NST)"
            }
          ],
          "text" : "Invasives Mammakarzinom, NST (ICD-O-3 8500/3)"
        },
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsGradingMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsGradingMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "44648-4",
              "display" : "Histologic grade [Score] in Breast cancer specimen by Nottingham"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-15",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "1155704001",
              "display" : "G3: Poorly differentiated"
            },
            {
              "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-grading",
              "code" : "3",
              "display" : "schlecht differenziert"
            }
          ],
          "text" : "G3 – schlecht differenziert (Elston-Ellis)"
        },
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsTNMklinischMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsTNMklinischMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "21908-9",
              "display" : "Stage group.clinical Cancer"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-16",
        "valueCodeableConcept" : {
          "text" : "cT2 cN1 cM0 – UICC IIB"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsEstrogenrezeptorMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsEstrogenrezeptorMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "85337-4",
              "display" : "Estrogen receptor Ag [Presence] in Breast cancer specimen by Immune stain"
            },
            {
              "system" : "http://snomed.info/sct",
              "code" : "1234806008",
              "display" : "Observation using immunohistochemistry (observable entity)"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-17",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA6577-6",
              "display" : "Negative"
            }
          ]
        },
        "note" : [
          {
            "text" : "Immunhistochemie: <1 % positive Kerne → ER-negativ."
          }
        ],
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsProgesteronrezeptorMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsProgesteronrezeptorMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "85339-0",
              "display" : "Progesterone receptor Ag [Presence] in Breast cancer specimen by Immune stain"
            },
            {
              "system" : "http://snomed.info/sct",
              "code" : "1234806008",
              "display" : "Observation using immunohistochemistry (observable entity)"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-17",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA6577-6",
              "display" : "Negative"
            }
          ]
        },
        "note" : [
          {
            "text" : "Immunhistochemie: <1 % positive Kerne → PR-negativ."
          }
        ],
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsHER2Mamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsHER2Mamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "48676-1",
              "display" : "HER2 Ag [Interpretation] in Tissue"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-17",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA6577-6",
              "display" : "Negative"
            },
            {
              "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-mamma-her2neu-status-obds",
              "code" : "N",
              "display" : "negativ"
            },
            {
              "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-onko/CodeSystem/mii-cs-onko-mamma-her2neu-status-leitlinie",
              "code" : "negativ",
              "display" : "HER2-negativ"
            }
          ]
        },
        "note" : [
          {
            "text" : "Immunhistochemie 1+ → HER2-negativ; keine In-situ-Hybridisierung erforderlich."
          }
        ],
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsKi67Mamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsKi67Mamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "85330-9",
              "display" : "Cells.Ki-67 nuclear Ag/cells in Breast cancer specimen by Immune stain"
            },
            {
              "system" : "http://snomed.info/sct",
              "code" : "1234806008",
              "display" : "Observation using immunohistochemistry (observable entity)"
            }
          ],
          "text" : "Ki-67 Proliferationsindex (MIB-1)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-17",
        "valueQuantity" : {
          "value" : 70,
          "unit" : "%",
          "system" : "http://unitsofmeasure.org",
          "code" : "%"
        },
        "specimen" : {
          🔗 "reference" : "Specimen/SpecimenBiopsieMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsGBRCAMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsGBRCAMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "21639-0",
              "display" : "BRCA1 gene mutations tested for in Blood or Tissue by Molecular genetics method Nominal"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-09-25",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "260385009",
              "display" : "Negative"
            }
          ]
        },
        "note" : [
          {
            "text" : "gBRCA1/2: keine (wahrscheinlich) pathogene Variante (Klasse 4/5) nachgewiesen."
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/EpisodeOfCare/TherapielinieChemo",
      "resource" : {
        "resourceType" : "EpisodeOfCare",
        "id" : "TherapielinieChemo",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-line"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "hauptintention",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://snomed.info/sct",
                      "code" : "373847000",
                      "display" : "Neoadjuvant intent"
                    }
                  ]
                }
              },
              {
                "url" : "phase",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://snomed.info/sct",
                      "code" : "373808002",
                      "display" : "Curative - procedure intent"
                    }
                  ]
                }
              }
            ],
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-intent"
          },
          {
            "extension" : [
              {
                "url" : "setting",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/enlist-lot-setting",
                      "code" : "eLoT",
                      "display" : "eLoT — frühes Setting"
                    }
                  ]
                }
              },
              {
                "url" : "line",
                "valuePositiveInt" : 1
              },
              {
                "url" : "modification",
                "valueUnsignedInt" : 0
              },
              {
                "url" : "notation",
                "valueString" : "eLoT 1.0"
              },
              {
                "url" : "lineId",
                "valueIdentifier" : {
                  "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/sid/enlist-line",
                  "value" : "mamma-baumann-elot-1"
                }
              }
            ],
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/enlist-lot"
          },
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/enlist-countable",
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/enlist-countable",
                  "code" : "counted",
                  "display" : "Zählt in der LoT-Zählung"
                }
              ]
            }
          },
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-line-medication-request",
            "valueReference" : {
              🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
            }
          }
        ],
        "status" : "finished",
        "type" : [
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "385786002",
                "display" : "Chemotherapy care"
              }
            ]
          }
        ],
        "diagnosis" : [
          {
            "condition" : {
              🔗 "reference" : "Condition/ConditionMamma"
            },
            "role" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/diagnosis-role",
                  "code" : "CC",
                  "display" : "Chief complaint"
                }
              ]
            },
            "rank" : 1
          }
        ],
        "patient" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "managingOrganization" : {
          🔗 "reference" : "Organization/Tumorboard"
        },
        "period" : {
          "start" : "2025-10-01",
          "end" : "2026-03-15"
        },
        "careManager" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "EpisodeOfCare"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/EpisodeOfCare/TherapielinieOperation",
      "resource" : {
        "resourceType" : "EpisodeOfCare",
        "id" : "TherapielinieOperation",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-line"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "hauptintention",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://snomed.info/sct",
                      "code" : "373808002",
                      "display" : "Curative - procedure intent"
                    }
                  ]
                }
              }
            ],
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-intent"
          },
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/enlist-countable",
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/enlist-countable",
                  "code" : "not-counted",
                  "display" : "Zählt nicht"
                }
              ]
            }
          }
        ],
        "status" : "finished",
        "type" : [
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "387713003",
                "display" : "Surgical procedure"
              }
            ]
          }
        ],
        "diagnosis" : [
          {
            "condition" : {
              🔗 "reference" : "Condition/ConditionMamma"
            },
            "role" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/diagnosis-role",
                  "code" : "CC",
                  "display" : "Chief complaint"
                }
              ]
            },
            "rank" : 1
          }
        ],
        "patient" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "managingOrganization" : {
          🔗 "reference" : "Organization/Tumorboard"
        },
        "period" : {
          "start" : "2026-03-20",
          "end" : "2026-04-06"
        },
        "referralRequest" : [
          {
            🔗 "reference" : "ServiceRequest/ServiceRequestProcedure"
          }
        ],
        "careManager" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "EpisodeOfCare"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Goal/TherapiezielMammaHeilung",
      "resource" : {
        "resourceType" : "Goal",
        "id" : "TherapiezielMammaHeilung",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-goal"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "hauptintention",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://snomed.info/sct",
                      "code" : "373808002",
                      "display" : "Curative - procedure intent"
                    }
                  ]
                }
              }
            ],
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-intent"
          },
          {
            "extension" : [
              {
                "url" : "individual",
                "valueReference" : {
                  🔗 "reference" : "Patient/PatientinMamma"
                }
              },
              {
                "url" : "status",
                "valueCode" : "agree"
              },
              {
                "url" : "priority",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
                      "code" : "high-priority",
                      "display" : "High Priority"
                    }
                  ]
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-acceptance"
          },
          {
            "extension" : [
              {
                "url" : "type",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/goal-relationship-type",
                      "code" : "predecessor",
                      "display" : "Predecessor"
                    }
                  ]
                }
              },
              {
                "url" : "target",
                "valueReference" : {
                  🔗 "reference" : "Goal/DiagnosticGoal"
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-relationship"
          },
          {
            "extension" : [
              {
                "url" : "type",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/goal-relationship-type",
                      "code" : "successor",
                      "display" : "Successor"
                    }
                  ]
                }
              },
              {
                "url" : "target",
                "valueReference" : {
                  🔗 "reference" : "Goal/FollowUpGoal"
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-relationship"
          }
        ],
        "lifecycleStatus" : "active",
        "achievementStatus" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-achievement",
              "code" : "achieved",
              "display" : "Achieved"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/onko-therapy-goal-type",
                "code" : "heilung",
                "display" : "Heilung"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/onko-therapy-goal-type",
                "code" : "funktionserhalt",
                "display" : "Funktionserhalt"
              }
            ]
          }
        ],
        "priority" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
              "code" : "high-priority",
              "display" : "High Priority"
            }
          ]
        },
        "description" : {
          "text" : "Kurative Behandlung des frühen triple-negativen Mammakarzinoms mittels neoadjuvanter Systemtherapie und brusterhaltender Operation; Erreichen einer pathologischen Komplettremission (pCR)."
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "startDate" : "2025-09-22",
        "target" : [
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21908-9",
                  "display" : "Stage group.clinical Cancer"
                }
              ]
            },
            "dueDate" : "2026-04-15"
          }
        ],
        "expressedBy" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "outcomeReference" : [
          {
            🔗 "reference" : "Observation/ObsDiseaseStatusMamma"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Goal"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestProcedure",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestProcedure",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-tumorboard-service-request"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "active",
        "intent" : "proposal",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://loinc.org",
                "code" : "85232-7",
                "display" : "Tumor board Consult note"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "387713003",
                "display" : "Surgical procedure"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "392021009",
              "display" : "Lumpectomy of breast (procedure)"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma",
      "resource" : {
        "resourceType" : "MedicationRequest",
        "id" : "MedicationRequestPembroChemoNeoadjuvantMamma",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-tumorboard-medication-request"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/enlist-change",
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/enlist-change-type",
                  "code" : "new",
                  "display" : "New LoT"
                }
              ]
            }
          }
        ],
        "status" : "completed",
        "intent" : "plan",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://loinc.org",
                "code" : "85232-7",
                "display" : "Tumor board Consult note"
              }
            ]
          }
        ],
        "medicationCodeableConcept" : {
          "text" : "Pembrolizumab + Carboplatin/Paclitaxel, gefolgt von Pembrolizumab + Epirubicin/Cyclophosphamid (KEYNOTE-522)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "MedicationRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma1",
      "resource" : {
        "resourceType" : "MedicationAdministration",
        "id" : "MedicationAdministrationPembroChemoNeoadjuvantMamma1",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "medicationCodeableConcept" : {
          "text" : "Pembrolizumab + Carboplatin (q3w), Paclitaxel wöchentlich begleitend (KEYNOTE-522, Phase 1)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-10-01",
        "request" : {
          🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
        },
        "note" : [
          {
            "text" : "Zyklus 1 von 4 (Pembro/Carbo q3w); begleitend wöchentliche Paclitaxel-Gaben, hier nicht einzeln erfasst"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "MedicationAdministration"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma2",
      "resource" : {
        "resourceType" : "MedicationAdministration",
        "id" : "MedicationAdministrationPembroChemoNeoadjuvantMamma2",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "medicationCodeableConcept" : {
          "text" : "Pembrolizumab + Carboplatin (q3w), Paclitaxel wöchentlich begleitend (KEYNOTE-522, Phase 1)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2025-11-01",
        "request" : {
          🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
        },
        "note" : [
          {
            "text" : "Zyklus 2 von 4 (Pembro/Carbo q3w); begleitend wöchentliche Paclitaxel-Gaben, hier nicht einzeln erfasst"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "MedicationAdministration"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma3",
      "resource" : {
        "resourceType" : "MedicationAdministration",
        "id" : "MedicationAdministrationPembroChemoNeoadjuvantMamma3",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "medicationCodeableConcept" : {
          "text" : "Pembrolizumab + Carboplatin (q3w), Paclitaxel wöchentlich begleitend (KEYNOTE-522, Phase 1)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2026-02-10",
        "request" : {
          🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
        },
        "note" : [
          {
            "text" : "Zyklus 3 von 4 (Pembro/Carbo q3w); begleitend wöchentliche Paclitaxel-Gaben, hier nicht einzeln erfasst"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "MedicationAdministration"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma4",
      "resource" : {
        "resourceType" : "MedicationAdministration",
        "id" : "MedicationAdministrationPembroChemoNeoadjuvantMamma4",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "medicationCodeableConcept" : {
          "text" : "Pembrolizumab + Carboplatin (q3w), Paclitaxel wöchentlich begleitend (KEYNOTE-522, Phase 1)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2026-03-15",
        "request" : {
          🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
        },
        "note" : [
          {
            "text" : "Zyklus 4 von 4 (Pembro/Carbo q3w); begleitend wöchentliche Paclitaxel-Gaben, hier nicht einzeln erfasst"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "MedicationAdministration"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Procedure/ProcedureOperationMamma",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ProcedureOperationMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "completed",
        "code" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "392021009",
              "display" : "Lumpectomy of breast (procedure)"
            }
          ],
          "text" : "Brusterhaltende Operation (BET) links + Sentinel-Lymphknoten-Biopsie"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "performedDateTime" : "2026-04-02"
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsTNMpathologischMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsTNMpathologischMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "21902-2",
              "display" : "Stage group.pathology Cancer"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2026-04-07",
        "valueCodeableConcept" : {
          "text" : "ypT0 ypN0 – pathologische Komplettremission (pCR)"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Observation/ObsDiseaseStatusMamma",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ObsDiseaseStatusMamma",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "final",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "97509-4",
              "display" : "Cancer disease progression"
            }
          ]
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "effectiveDateTime" : "2026-04-07",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://snomed.info/sct",
              "code" : "260415000",
              "display" : "Not detected"
            }
          ]
        },
        "note" : [
          {
            "text" : "Pathologische Komplettremission (pCR, ypT0 ypN0) nach neoadjuvanter Systemtherapie."
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/CarePlan/CarePlanMammaNeoadjuvant",
      "resource" : {
        "resourceType" : "CarePlan",
        "id" : "CarePlanMammaNeoadjuvant",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-care-plan"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-careplan-custodian",
            "valueReference" : {
              🔗 "reference" : "Organization/TumorzentrumMamma"
            }
          }
        ],
        "status" : "active",
        "intent" : "plan",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "736252007",
                "display" : "Cancer care plan"
              }
            ]
          }
        ],
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "period" : {
          "start" : "2025-09-22"
        },
        "author" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "goal" : [
          {
            🔗 "reference" : "Goal/TherapiezielMammaHeilung"
          }
        ],
        "activity" : [
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma1"
              },
              {
                🔗 "reference" : "MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma2"
              },
              {
                🔗 "reference" : "MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma3"
              },
              {
                🔗 "reference" : "MedicationAdministration/MedicationAdministrationPembroChemoNeoadjuvantMamma4"
              }
            ],
            "reference" : {
              🔗 "reference" : "MedicationRequest/MedicationRequestPembroChemoNeoadjuvantMamma"
            }
          },
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Procedure/ProcedureOperationMamma"
              }
            ],
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestProcedure"
            }
          },
          {
            "reference" : {
              🔗 "reference" : "MedicationRequest/MedicationRequestPembroAdjuvantMamma"
            }
          },
          {
            "outcomeReference" : [
              {
                🔗 "reference" : "Observation/ObsDiseaseStatusMamma"
              }
            ]
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "CarePlan"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/Goal/FollowUpGoal",
      "resource" : {
        "resourceType" : "Goal",
        "id" : "FollowUpGoal",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-therapy-goal"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "individual",
                "valueReference" : {
                  🔗 "reference" : "Patient/PatientinMamma"
                }
              },
              {
                "url" : "status",
                "valueCode" : "agree"
              },
              {
                "url" : "priority",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
                      "code" : "high-priority",
                      "display" : "High Priority"
                    }
                  ]
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-acceptance"
          },
          {
            "extension" : [
              {
                "url" : "type",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/goal-relationship-type",
                      "code" : "predecessor",
                      "display" : "Predecessor"
                    }
                  ]
                }
              },
              {
                "url" : "target",
                "valueReference" : {
                  🔗 "reference" : "Goal/DiagnosticGoal"
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-relationship"
          },
          {
            "extension" : [
              {
                "url" : "type",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://hl7.org/fhir/goal-relationship-type",
                      "code" : "predecessor",
                      "display" : "Predecessor"
                    }
                  ]
                }
              },
              {
                "url" : "target",
                "valueReference" : {
                  🔗 "reference" : "Goal/TherapiezielMammaHeilung"
                }
              }
            ],
            "url" : "http://hl7.org/fhir/StructureDefinition/goal-relationship"
          }
        ],
        "lifecycleStatus" : "planned",
        "achievementStatus" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-achievement",
              "code" : "in-progress",
              "display" : "In Progress"
            }
          ]
        },
        "category" : [
          {
            "coding" : [
              {
                "system" : "https://bih-cei.de/fhir/therapieziele-onkologie/CodeSystem/onko-therapy-goal-type",
                "code" : "lebensqualitaet",
                "display" : "Lebensqualität"
              }
            ]
          }
        ],
        "priority" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/goal-priority",
              "code" : "high-priority",
              "display" : "High Priority"
            }
          ]
        },
        "description" : {
          "text" : "Monitoring der Lebensqualität und des Krankheitsstatus nach der onkologischen Erkrankung und Therapie"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "startDate" : "2026-08-15",
        "target" : [
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "21976-6",
                  "display" : "Cancer outcome status"
                }
              ]
            },
            "detailCodeableConcept" : {
              "text" : "Kein Hinweis auf Lokalrezidiv oder Fernmetastasen"
            },
            "dueDate" : "2026-11-15"
          },
          {
            "measure" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "24606-6",
                  "display" : "Mammografie"
                }
              ]
            },
            "detailCodeableConcept" : {
              "text" : "Unauffällige Nachsorge-Mammographie (jährlich), kein Rezidivnachweis"
            },
            "dueDate" : "2027-04-15"
          },
          {
            "measure" : {
              "text" : "Arm-/Schulterfunktion und Lymphödem-Status nach axillärem Eingriff"
            },
            "detailCodeableConcept" : {
              "text" : "Kein manifestes Lymphödem, erhaltene Schulterbeweglichkeit"
            }
          },
          {
            "measure" : {
              "text" : "Gesundheitsbezogene Lebensqualität (PROM, EORTC QLQ-C30 / BR23) – MII PRO-Modul"
            },
            "detailCodeableConcept" : {
              "text" : "Stabile bis verbesserte Lebensqualität im Verlauf"
            }
          }
        ],
        "expressedBy" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "outcomeReference" : [
          {
            🔗 "reference" : "Observation/ObsDiseaseStatusMamma"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Goal"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/ServiceRequest/ServiceRequestMammographieNachsorge",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ServiceRequestMammographieNachsorge",
        "language" : "en",
        "text" : {
          "status" : "generated"
        },
        "status" : "active",
        "intent" : "plan",
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "24606-6",
              "display" : "Mammografie"
            }
          ],
          "text" : "Nachsorge-Mammographie beidseits (jährlich)"
        },
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "occurrenceDateTime" : "2027-04-15",
        "requester" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "reasonReference" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "http://example.org/fhir/CarePlan/CarePlanMammaNachsorge",
      "resource" : {
        "resourceType" : "CarePlan",
        "id" : "CarePlanMammaNachsorge",
        "meta" : {
          "profile" : [
            🔗 "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-care-plan"
          ]
        },
        "language" : "en",
        "text" : {
          "status" : "extensions"
        },
        "extension" : [
          {
            "url" : "https://bih-cei.de/fhir/therapieziele-onkologie/StructureDefinition/onko-careplan-custodian",
            "valueReference" : {
              🔗 "reference" : "Organization/TumorzentrumMamma"
            }
          }
        ],
        "status" : "active",
        "intent" : "plan",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "code" : "736252007",
                "display" : "Cancer care plan"
              }
            ]
          }
        ],
        "subject" : {
          🔗 "reference" : "Patient/PatientinMamma"
        },
        "period" : {
          "start" : "2026-08-15"
        },
        "author" : {
          🔗 "reference" : "Practitioner/OnkologinMamma"
        },
        "addresses" : [
          {
            🔗 "reference" : "Condition/ConditionMamma"
          }
        ],
        "goal" : [
          {
            🔗 "reference" : "Goal/FollowUpGoal"
          }
        ],
        "activity" : [
          {
            "reference" : {
              🔗 "reference" : "ServiceRequest/ServiceRequestMammographieNachsorge"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "CarePlan"
      }
    }
  ]
}